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Application of physiologically based pharmacokinetic models to promote the development of veterinary drugs with high efficacy and safety

期刊: JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 2021; 44 (5)

Physiologically based pharmacokinetic (PBPK) models have become important tools for the development of novel human drugs. Food-producing animals and p......

Pharmacokinetics of neomycin sulfate after intravenous and oral administrations in swine

期刊: JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 2021; 44 (5)

The aminoglycoside antibiotic neomycin, which is used to treat external or internal bacterial infections, is primarily administered in veterinary medi......

Pharmacokinetics of levofloxacin mesylate in healthy adult giant panda after single-dose administration via different routes

期刊: JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, ; ()

The pharmacokinetics of levofloxacin mesylate in healthy adult giant panda is unknown. In this study, the pharmacokinetics of levofloxacin after intra......

Pharmacokinetics, bioavailability, and tissue disposal profiles of Tiamulin fumarate in Nile tilapia (Oreochromis niloticus) following oral and intravenous administrations

期刊: JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, ; ()

Tiamulin fumarate (TIF) is a pleuromutilin antibiotic and has high activity against animal bacterial pathogens including aquatic bacterial pathogens. ......

Application of alpha(2)-adrenergic agonists combined with anesthetics and their implication in pulmonary intravascular macrophages-insulted pulmonary edema and hypoxemia in ruminants

期刊: JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, ; ()

Alpha(2)-adrenergic agonists have been implicated in the development of pulmonary edema (PE) and sustained hypoxemia that lead to life-threatening pul......

Recent advances in microencapsulation of drugs for veterinary applications

期刊: JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, ; ()

Microencapsulation is a process where very minute droplets or particles of solid or liquid or gas are trapped with a polymer to isolate the internal c......

Current review of isoxazoline ectoparasiticides used in veterinary medicine

期刊: JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, ; ()

The isoxazolines are a novel class of ectoparasiticides with potent inhibitory activity on glutamate- and gamma-aminobutyric acid-gated chloride chann......

Pharmacokinetics and bioavailability of tildipirosin in rabbits following single-dose intravenous and intramuscular administration

期刊: JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 2020; 43 (5)

The objective of this study was to determine the pharmacokinetics of tildipirosin in rabbits after a single intravenous (i.v.) and intramuscular (i.m.......

Comparison of the pharmacokinetics of tilmicosin in plasma and lung tissue in healthy chickens and chickens experimentally infected withMycoplasma gallisepticum

期刊: JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 2020; 43 (4)

The objectives of this study were to compare the plasma and lung tissue pharmacokinetics of tilmicosin in healthy andMycoplasma gallisepticum-infected......

Pharmacokinetics of three formulations of vitacoxib in horses

期刊: JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 2020; 43 (4)

The pharmacokinetic properties of three formulations of vitacoxib were investigated in horses. To describe plasma concentrations and characterize the ......

Disposition of cyadox in domesticated cats following oral, intramuscular, and intravenous administration

期刊: JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 2020; 43 (2)

Cyadox (CYX) is a synthetic antibacterial agent of quinoxaline with much lower toxic effects. A safety criterion of CYX for clinical use was establish......

Sanguinarine metabolism and pharmacokinetics study in vitro and in vivo

期刊: JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 2020; 43 (2)

Sanguinarine (SA) is a benzo[c] phenanthridine alkaloid which has a variety of pharmacological properties. However, very little was known about the ph......

Considerations for application of biopharmaceutics classification system in chicken: Exemplified by seven drugs classification

期刊: JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 2020; 43 (2)

Biopharmaceutics Classification System (BCS) has gained broad acceptance in promoting the development of human drugs. To date, the applicability of ex......

Pharmacokinetics of ceftiofur sodium in Peekapoo dogs following a single intravenous and subcutaneous injection

期刊: JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 2020; 43 (4)

The present study aimed to determine the pharmacokinetic profiles of ceftiofur (as measured by ceftiofur and its active metabolites concentrations) in......

Pharmacokinetics of extended-release ivermectin microspheres after oral administration to healthy pigs

期刊: JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 2020; 43 (5)

We compared the pharmacokinetics of ivermectin premix and ivermectin microspheres in pigs after single and multiple administration regimes. In the sin......

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