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Characterization of an i.p. D-galactose-induced cataract model in rats

期刊: JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 2021; 107 ()

Cataracts have been identified as a main cause of global visual impairment and blindness; in addition, diabetic and aging cataracts are the most commo......

An improved two-step method for extraction and purification of primary cardiomyocytes from neonatal mice

期刊: JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 2020; 104 ()

Introduction: Primary mouse cardiomyocytes are essential tools for cardiovascular pharmacology research at the cellular and molecular levels, but thei......

Establishment of drug screening in human embryonic stem cells based on a high-content screening system

期刊: JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 2020; 106 ()

High-content screening (HCS) systems can be used for high-throughput screening of drugs in human embryonic stem cells (hESCs). However, hESCs require ......

Comparison of three analytical methods for superoxide produced by activated immune cells

期刊: JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 2020; 101 ()

Superoxide plays a key role in normal immune function and inflammatory diseases. In order to evaluate normal immune function or screen inhibitors of s......

Murine models of psoriasis and its applications in drug development

期刊: JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 2020; 101 ()

Psoriasis is an autoimmune skin disease which characteristic of a well-demarcated, erythematous, raised lesion with silvery-white dry scale. Although ......

A low-cost, accurate method for detecting reticulocytes at different maturation stages based on changes in the mitochondrial membrane potential

期刊: JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 2020; 101 ()

In the clinical setting, reticulocytes are used as an index for the hematopoietic function of the bone marrow. Different maturation stages of reticulo......

Three-dimensional integrated quantitative modeling and fluorescent imaging of doxorubicin-induced cardiotoxicity in a whole organ using a deconvolution microscope

期刊: JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 2020; 101 ()

The quantification and visualization of fluorescent staining at the whole organ level remain a challenge. Deconvolution image systems allow multi-dime......

A natural complex product Yaocha reduces uric acid level in a live zebrafish model

期刊: JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 2020; 102 ()

Introduction: This study was aimed to assess uric acid (UA)-lowering effect and its possible mechanisms of a natural complex product Yaocha in a live ......

Systematic characterization of AT1 receptor antagonists with label-free dynamic mass redistribution assays

期刊: JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 2020; 102 ()

Introduction: In the drug discovery field, the binding affinities and binding kinetics of drug candidates are very important. Angiotensin II type 1 (A......

Antibodies against polyethylene glycol in human blood: A literature review

期刊: JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 2020; 102 ()

Polyethylene glycol (PEG) conjugation, i.e. PEGylation, is a successful strategy to improve the pharmacokinetics and pharmacodynamics of biopharmaceut......

A novel experimental intraperitoneal infection model for Haemophilus parasuis in neutropenic guinea pigs

期刊: JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 2019; 95 ()

Introduction: Haemophilus parasuis, one of the major swine pathogens, has at least fifteen different types, all of which have significant economic eff......

JIF:2.68

A label-free approach to detect cell viability/cytotoxicity based on intracellular xanthine/guanine by electrochemical method

期刊: JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 2019; 100 ()

Introduction: Cell viability and cytotoxicity is one of the most important toxicology indicators. In this study, an electrochemical method for detecti......

JIF:2.68

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