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Rubus chingii var. suavissimus alleviates high-fat diet-induced lipid metabolism disorder via modulation of the PPARs/SREBP pathway in Syrian golden hamsters

期刊: JOURNAL OF NATURAL MEDICINES, 2021; 75 (4)

While the underlying mechanism remains unknown, Rubus chingii var. suavissimus (S. K. Lee) L. T. Lu or Rubus suavissimus S. Lee (RS), a sweet plant di......

UHPLC-MS-based metabolomic approach for the quality evaluation of Pinelliaternata tubers grown in shaded environments

期刊: JOURNAL OF NATURAL MEDICINES, 2021; 75 (4)

Pinellia ternata is a native herb in China, and its tuber is widely-used in traditional Chinese medicines. It has been identified that the shading tre......

beta-elemene affects angiogenesis of infantile hemangioma by regulating angiotensin-converting enzyme 2 and hypoxia-inducible factor-1 alpha

期刊: JOURNAL OF NATURAL MEDICINES, 2021; 75 (3)

Infantile hemangioma (IH) is the most common benign vascular tumor resulting from the hyper-proliferation of vascular endothelial cells. In treatment ......

Phelligridin D from Inonotus obliquus attenuates oxidative stress and accumulation of ECM in mesangial cells under high glucose via activating Nrf2

期刊: JOURNAL OF NATURAL MEDICINES, 2021; 75 (4)

Diabetic nephropathy (DN) is one of the most common microvascular complications of diabetes mellitus and becomes the financial burden and health probl......

The hepatoprotective efficacy and biological mechanisms of three phenylethanoid glycosides from cistanches herba and their metabolites based on intestinal bacteria and network pharmacology

期刊: JOURNAL OF NATURAL MEDICINES, 2021; 75 (4)

Echinacoside (ECH), acteoside (ACT), and isoacteoside (ISAT), the typical phenylethanoid glycosides (PhGs) in cistanches herba, have various pharmacol......

Cytotoxicity and growth-inhibiting activity of Astragalus polysaccharides against breast cancer via the regulation of EGFR and ANXA1

期刊: JOURNAL OF NATURAL MEDICINES, 2021; 75 (4)

Astragalus polysaccharide (APS) has been frequently used as an adjuvant agent responsible for its immunoregulatory activity to enhance efficacy and re......

Dibenzocyclooctadiene lignans from Artemisia sieversiana and their anti-inflammatory activities

期刊: JOURNAL OF NATURAL MEDICINES, 2021; 75 (4)

Two previously undescribed dibenzocyclooctadiene lignans, named sieverlignans D-E (1-2), as well as eight known ones (3-10), were isolated from the ae......

Genetic diversity of Amomum xanthioides and its related species from Southeast Asia and China

期刊: JOURNAL OF NATURAL MEDICINES, 2021; 75 (4)

Amomum Semen, the seed mass of Amomum xanthioides, has been imported from Southeast Asia and China and used for the treatment of gastric and intestina......

Identification of anti-HIV macrocyclic daphnane orthoesters from Wikstroemia ligustrina by LC-MS analysis and phytochemical investigation

期刊: JOURNAL OF NATURAL MEDICINES, 2021; 75 (4)

Macrocyclic daphnane orthoesters (MDOs) have attracted significant research interest for the drug discovery to cure HIV infection based on the "Shock ......

Dehydroabietic acid improves nonalcoholic fatty liver disease through activating the Keap1/Nrf2-ARE signaling pathway to reduce ferroptosis

期刊: JOURNAL OF NATURAL MEDICINES, ; ()

The accumulation of iron-dependent lipid peroxides is one of the important causes of NAFLD. The purpose of this study is to explore the effect of dehy......

Five matrine-type alkaloids from Sophora tonkinensis

期刊: JOURNAL OF NATURAL MEDICINES, ; ()

Five matrine-type alkaloids (1-5) including two new compounds (1 and 3) and a new natural product (2) were isolated from the roots of Sophora tonkines......

Alginic acid inhibits non-small cell lung cancer-induced angiogenesis via activating miR-506 expression

期刊: JOURNAL OF NATURAL MEDICINES, ; ()

Angiogenesis is a key event in non-small cell lung cancer progression. Alginic acid (AA), a kind of naturally occurring polyuronic acid, is generally ......

Curcumin suppresses LGR5(+) colorectal cancer stem cells by inducing autophagy and via repressing TFAP2A-mediated ECM pathway

期刊: JOURNAL OF NATURAL MEDICINES, ; ()

Colorectal cancer stem cells (CSCs) have the potential for self-renewal, proliferation, and differentiation. And LGR5 is a stem cell marker gene of co......

Indole-3-carboxaldehyde regulates RSV-induced inflammatory response in RAW264.7 cells by moderate inhibition of the TLR7 signaling pathway

期刊: JOURNAL OF NATURAL MEDICINES, ; ()

Human respiratory syncytial virus (RSV) is highly contagious and the leading cause of severe respiratory tract illness in infants, elderly, and immuno......

Quality evaluation of Pinellia tuber by LC-TOF/MS targeted to ephedrine

期刊: JOURNAL OF NATURAL MEDICINES, ; ()

Pinellia tuber (PTE, (sic)) is derived from the tuber of Pinellia ternata Breitenbach (Araceae), which is a crude drug used in traditional Japanese Ka......

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