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Acupuncture modulates extracellular ATP levels in peripheral sensory nervous system during analgesia of ankle arthritis in rats

期刊: PURINERGIC SIGNALLING, 2021; 17 (3)

As an ancient analgesia therapy, acupuncture has been practiced worldwide nowadays. A good understanding of its mechanisms will offer a promise for it......

Enhanced expression of P2X4 purinoceptors in pyramidal neurons of the rat hippocampal CA1 region may be involved ischemia-reperfusion injury

期刊: PURINERGIC SIGNALLING, 2021; 17 (3)

Ischemic stroke is the most serious disease that harms human beings. In principle, its treatment is to restore blood flow supply as soon as possible. ......

Optical control of purinergic signaling

期刊: PURINERGIC SIGNALLING, 2021; 17 (3)

Purinergic signaling plays a pivotal role in physiological processes and pathological conditions. Over the past decades, conventional pharmacological,......

Targeting P2 receptors in purinergic signaling: a new strategy of active ingredients in traditional Chinese herbals for diseases treatment

期刊: PURINERGIC SIGNALLING, ; ()

Adenosine triphosphate (ATP) and its metabolites adenosine diphosphate, adenosine monophosphate, and adenosine in purinergic signaling pathway play im......

Effect of P2X purinergic receptors in tumor progression and as a potential target for anti-tumor therapy

期刊: PURINERGIC SIGNALLING, 2021; 17 (1)

The development of tumors is a complex pathological process involving multiple factors, multiple steps, and multiple genes. Their prevention and treat......

Protective effects of dihydromyricetin on primary hippocampal astrocytes from cytotoxicity induced by comorbid diabetic neuropathic pain and depression

期刊: PURINERGIC SIGNALLING, 2020; 16 (4)

Activated astrocytes play a key role in diabetic neuropathic pain and depression. We aimed to assess the protective effects of dihydromyricetin (DHM) ......

Expression of P2X receptors in the rat anterior pituitary

期刊: PURINERGIC SIGNALLING, 2020; 16 (1)

In this study, the distribution patterns of P2X1 to P2X7 receptors in the anterior pituitary cells of rat were studied with single-, double-, and trip......

The belated US FDA approval of the adenosine A(2A) receptor antagonist istradefylline for treatment of Parkinson's disease

期刊: PURINERGIC SIGNALLING, 2020; 16 (2)

After more than two decades of preclinical and clinical studies, on August 27, 2019, the US Food and Drug Administration (FDA) approved the adenosine ......

Reactive oxygen species play a role in P2X7 receptor-mediated IL-6 production in spinal astrocytes

期刊: PURINERGIC SIGNALLING, 2020; 16 (1)

Astrocytes mediate a remarkable variety of cellular functions, including gliotransmitter release. Under pathological conditions, high concentrations o......

Purinergic signaling as a basis of acupuncture-induced analgesia

期刊: PURINERGIC SIGNALLING, 2020; 16 (3)

This review summarizes experimental evidence indicating that purinergic mechanisms are causally involved in acupuncture (AP)-induced analgesia. Electr......

Electroacupuncture improves myocardial ischemia injury via activation of adenosine receptors

期刊: PURINERGIC SIGNALLING, 2020; 16 (3)

Electroacupuncture (EA) can improve myocardial ischemia (MI) injury; nevertheless, the mechanism is not entirely clear. And there were disagreements a......

High expression levels of pyrimidine metabolic rate-limiting enzymes are adverse prognostic factors in lung adenocarcinoma: a study based on The Cancer Genome Atlas and Gene Expression Omnibus datasets

期刊: PURINERGIC SIGNALLING, 2020; 16 (3)

Reprogramming of metabolism is described in many types of cancer and is associated with the clinical outcomes. However, the prognostic significance of......

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