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Therapeutic impact of thymoquninone to alleviate ischemic brain injury via Nrf2/HO-1 pathway

期刊: EXPERT OPINION ON THERAPEUTIC TARGETS, 2021; 25 (7)

Introduction: Reactive oxygen species (ROS)-mediated inflammation plays a crucial role in ischemic brain injury. Therefore, the activation of the nucl......

Macrophage polarization: an effective approach to targeted therapy of inflammatory bowel disease

期刊: EXPERT OPINION ON THERAPEUTIC TARGETS, 2021; 25 (3)

Introduction: Inflammatory bowel disease (IBD) is a systemic disease with immune abnormalities that can affect the entire digestive tract. A high perc......

Inflammasomes: a preclinical assessment of targeting in atherosclerosis

期刊: EXPERT OPINION ON THERAPEUTIC TARGETS, 2020; 24 (9)

Introduction Inflammasomes are central to atherosclerotic vascular dysfunction with regulatory effects on inflammation, immune modulation, and lipid m......

The emerging role of dipeptidyl-peptidase-4 as a therapeutic target in lung disease

期刊: EXPERT OPINION ON THERAPEUTIC TARGETS, 2020; 24 (2)

Introduction: Dipeptidyl-peptidase-4 (DPP-4) is a surface bound ectopeptidase that is commonly known as CD26 or adenosine deaminase binding protein. D......

Proteome of thymus and spleen reveals that 10-hydroxydec-2-enoic acid could enhance immunity in mice

期刊: EXPERT OPINION ON THERAPEUTIC TARGETS, 2020; 24 (3)

Objectives: 10-hydroxydec-2-enoic acid (10-HDA), a unique component of royal jelly existing only in nature, has the potential to promote human health.......

Cepharanthine hydrochloride induces mitophagy targeting GPR30 in hepatocellular carcinoma (HCC)

期刊: EXPERT OPINION ON THERAPEUTIC TARGETS, 2020; 24 (4)

Objectives: Cepharanthine exhibits a wide range of therapeutic effects against numerous cancers by virtue of its pleiotropic mechanisms. However, ceph......

Expression of a short antibody heavy chain peptide effectively antagonizes adenosine 2A receptor in vitro and in vivo

期刊: EXPERT OPINION ON THERAPEUTIC TARGETS, 2020; 24 (7)

Background: Adenosine 2A receptor (A(2A)R) is involved in many physiological and pathological functions and serves as an important drug target. Inhibi......

Inflammation resolution and specialized pro-resolving lipid mediators in CNS diseases

期刊: EXPERT OPINION ON THERAPEUTIC TARGETS, 2019; 23 (11)

Introduction: Inflammation resolution induced by specialized pro-resolving lipid mediators (SPMs) is a new concept. The application of SPMs is a promi......

JIF:4.62

Therapeutic potential of enhancer of zeste homolog 2 in autoimmune diseases

期刊: EXPERT OPINION ON THERAPEUTIC TARGETS, 0; ()

Introduction: Autoimmune diseases (ADs) are idiopathic and heterogeneous disorders with contentious pathophysiology. Great strides have been made in e......

AdipoRs- a potential therapeutic target for fibrotic disorders

期刊: EXPERT OPINION ON THERAPEUTIC TARGETS, 2019; 23 (2)

Introduction: Fibrotic disorders are a leading cause of morbidity and mortality; hence effective treatments are still vigorously sought. AdipoRs (Adip......

JIF:4.62

Targeting the cell signaling pathway Keap1-Nrf2 as a therapeutic strategy for adenocarcinomas of the lung

期刊: EXPERT OPINION ON THERAPEUTIC TARGETS, 2019; 23 (3)

Introduction: Kelch-like ECH associated protein 1/Nuclear factor erythroid 2-like factor 2 (Keap1-Nrf2) signaling plays a pivotal role in response to ......

JIF:4.62

The P2X7 receptor: a new therapeutic target in Alzheimer's disease

期刊: EXPERT OPINION ON THERAPEUTIC TARGETS, 2019; 23 (3)

Introduction: Alzheimer's disease (AD) is a neurodegenerative illness with genetic risk as an etiological factor in a subset of cases. In AD with auto......

JIF:4.62

TANK-binding kinase 1 as a novel therapeutic target for viral diseases

期刊: EXPERT OPINION ON THERAPEUTIC TARGETS, 2019; 23 (5)

Introduction: TANK-binding kinase 1 (TBK1) is vital for the induction of antiviral innate immune responses. Both RNA and DNA viral infection induces T......

JIF:4.62

Pro-resolving lipid mediators as therapeutic leads for cardiovascular diseases

期刊: EXPERT OPINION ON THERAPEUTIC TARGETS, 2019; 23 (5)

Introduction: Cardiovascular diseases are the leading cause of human death globally. Lipid mediators contribute to the initiation and resolution of in......

JIF:4.62

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