期刊： BIOPHARMACEUTICS & DRUG DISPOSITION, 2021; 42 (7)
This study was intended to delineate the profile of double-negative T cells (DNTs) in NOD.Cg-Prkdc(scid) Il2rg(tm1wj)/SzJ mice and cytokines released ......
期刊： BIOPHARMACEUTICS & DRUG DISPOSITION, 2021; 42 (8)
Age, hypercholesterolemia, and vitamin D deficiency are risk factors that increase the brain accumulation of pathogenic beta-amyloid peptides (40 and ......
期刊： BIOPHARMACEUTICS & DRUG DISPOSITION, 2021; 42 (8)
Gamma hydroxybutyric acid (GHB) has been approved clinically to treat excessive daytime sleepiness and cataplexy in patients with narcolepsy, alcohol ......
期刊： BIOPHARMACEUTICS & DRUG DISPOSITION, 2021; 42 (1)
To preliminarily develop physiologically based population models for Chinese renal impairment patients and to evaluate the prediction performance of n......
期刊： BIOPHARMACEUTICS & DRUG DISPOSITION, 2020; 41 (6)
Cancer therapy with tyrosine kinase inhibitors (TKIs) is a rapidly developing field, and several TKIs have been reported to have an impact on the acti......
期刊： BIOPHARMACEUTICS & DRUG DISPOSITION, 2020; 41 (6)
Aim The aim of this study was to build and verify a preliminary physiologically based pharmacokinetic (PBPK) model of Chinese pregnant women. The mode......
期刊： BIOPHARMACEUTICS & DRUG DISPOSITION, 2020; 41 (3)
Methotrexate (MTX) pharmacokinetics has substantial inter-individual variability and toxicity. In children with medulloblastoma treated with high-dose......
期刊： BIOPHARMACEUTICS & DRUG DISPOSITION, 2020; 41 (4-5)
Fasudil hydrochloride as an intracellular calcium ion antagonist that dilates blood vessels has exhibited a very potent pharmacological effect in the ......
期刊： BIOPHARMACEUTICS & DRUG DISPOSITION, 2020; 41 (4-5)
Background Recently the expression patterns of several cytochrome P450 (CYP) genes in different human osteoblast models were reported. However, the va......
期刊： BIOPHARMACEUTICS & DRUG DISPOSITION, 2019; 40 (1)
Metformin is always used as the baseline antidiabetic therapy for patients with type 2 diabetes mellitus (T2DM) and hyperuricemia. Metformin is excret......
期刊： BIOPHARMACEUTICS & DRUG DISPOSITION, 2019; 40 (2)
Multidrug resistance (MDR) is common in patients and has been linked to transforming growth factor-beta 1 (TGF-beta 1) and overexpression of drug effl......
期刊： BIOPHARMACEUTICS & DRUG DISPOSITION, 2019; 40 (3-4)
GL-V9, a derivative of wogonin, has potent anti-cancer activity. The absorption and metabolism of this compound have not been investigated systematica......
期刊： BIOPHARMACEUTICS & DRUG DISPOSITION, 2019; 40 (3-4)
Olerciamide A (OA) is a new alkaloid isolated from Portulaca oleracea L. that has been proved to possess a low bioavailability (F) after oral administ......
期刊： BIOPHARMACEUTICS & DRUG DISPOSITION, 2019; 40 (8)
The objective of this study was to investigate the absorption behavior of chikusetsusaponin IVa (CHS-IVa) in the rat intestine using single-pass intes......
期刊： BIOPHARMACEUTICS & DRUG DISPOSITION, 2020; 41 (1-2)
Affecting the absorption of active ingredients in the intestine serves as one of the important compatibility mechanisms of traditional Chinese medicin......
