期刊： EXPERT OPINION ON THERAPEUTIC PATENTS, 2021; 31 (8)
Introduction Fibrosis is a serious disease that occurs in many organs, such as kidney, liver and lung. The deterioration of these organs ultimately le......
期刊： EXPERT OPINION ON THERAPEUTIC PATENTS, 2021; 31 (9)
Introduction: Akt is a widely known serine threonine kinase involved in a series of critical cellular pathways like cell survival and proliferation. W......
期刊： EXPERT OPINION ON THERAPEUTIC PATENTS, 2021; 31 (5)
Introduction: DNA-dependent protein kinase (DNA-PK) plays a crucial role in the repair of DSBs via non-homologous end joining (NHEJ). Several DNA-PK i......
期刊： EXPERT OPINION ON THERAPEUTIC PATENTS, 2021; 31 (7)
Introduction: Aurora kinases are a family of serine/threonine kinases, and promote mitotic spindle assembly by regulating centrosome duplication and s......
期刊： EXPERT OPINION ON THERAPEUTIC PATENTS, 2021; 31 (9)
Introduction: Type 2 diabetes is a rapid-growing complex chronic metabolic disease characterized by hyperglycemia due to lessened insulin secretion, i......
期刊： EXPERT OPINION ON THERAPEUTIC PATENTS, ; ()
Introduction Stimulator of interferon genes (STING) is a transmembrane protein that localizes in the endoplasmic reticulum. As a crucial adaptor prote......
期刊： EXPERT OPINION ON THERAPEUTIC PATENTS, ; ()
Introduction: The ATX-LPA axis is an attractive target for therapeutic intervention in a variety of diseases, such as tumor metastasis, fibrosis, prur......
期刊： EXPERT OPINION ON THERAPEUTIC PATENTS, 2020; 30 (9)
Introduction Hepatitis B disease is caused by the hepatitis B virus (HBV), which is a DNA virus that belongs to the Hepadnaviridae family. It is a con......
期刊： EXPERT OPINION ON THERAPEUTIC PATENTS, 2020; 30 (9)
Introduction Therapeutic antibodies blocking co-inhibitory pathways do not attack tumor cells directly, but instead bind to their targeted proteins an......
期刊： EXPERT OPINION ON THERAPEUTIC PATENTS, 2020; 30 (4)
Introduction: Histone deacetylase (HDAC) inhibitors play a crucial role in restoring the balance of acetylation and deacetylation of lysine residues o......
期刊： EXPERT OPINION ON THERAPEUTIC PATENTS, 2020; 30 (5)
Introduction: Discoidin domain receptor 1 (DDR1) is a collagen-activated receptor tyrosine kinase. Upon collagen binding, DDR1 undergoes tyrosine auto......
期刊： EXPERT OPINION ON THERAPEUTIC PATENTS, 2019; 29 (12)
Introduction: PI3K delta is an important subtype of PI3K kinases, which is mainly expressed in leukocytes and plays an important role in the prolifera......
期刊： EXPERT OPINION ON THERAPEUTIC PATENTS, 2019; 29 (1)
Introduction: The receptor tyrosine kinase c-Met is involved in the formation, metastasis and invasion of various malignant tumors thus it has been an......
期刊： EXPERT OPINION ON THERAPEUTIC PATENTS, 2019; 29 (2)
Introduction: Tyrosine kinase 2 (Tyk2) is a non-receptor tyrosine-protein kinase, an enzyme that in humans is encoded by the TYK2 gene. Tyk2, together......
期刊： EXPERT OPINION ON THERAPEUTIC PATENTS, 2019; 29 (2)
Introduction: By 2020, nearly one million people will live with Parkinson's disease (PD) in the U.S. This disorder has a significant impact on patient......
