期刊: NATURE CANCER, 2021; 2 (4)
Although chemotherapy can stimulate antitumor immunity by inducing interferon (IFN) response, the functional role of tumor-associated macrophages in t......
期刊: NATURE CANCER, 2021; 2 (6)
Post-transcriptional modifications of RNA constitute an emerging regulatory layer of gene expression. The demethylase fat mass- and obesity-associated......
期刊: NATURE CANCER, 2021; 2 (4)
Tyrosine kinase inhibitors (TKIs) have dramatically changed the clinical prospects of patients with non-small cell lung cancer harboring epidermal gro......
期刊: NATURE CANCER, 2021; 2 (8)
Chemotherapy is a standard treatment for pediatric acute lymphoblastic leukemia (ALL), which sometimes relapses with chemoresistant features. However,......
期刊: NATURE CANCER, 2021; 2 (7)
Kharas and colleagues identify the RNA-binding proteins RBMX and RBMXL1 as AML tumor promoters that alter chromatin compaction and hence cell survival......
期刊: NATURE CANCER, 2021; 2 (6)
Combining cyclin-dependent kinase (CDK) inhibitors with endocrine therapy improves outcomes for patients with metastatic estrogen receptor-positive br......
期刊: NATURE CANCER, 2021; 2 (8)
Melenhorst and colleagues review the current status of chimeric antigen receptor T cell therapies, focusing on the rapid progress achieved in this are......
Cyclin-dependent kinases (CDKs) 4 and 6 inhibitors (CDK4/6is) are effective in metastatic breast cancer, but they have been only modestly effective in......
期刊: NATURE CANCER, 2021; 2 (1)
Kras-activating mutations display the highest incidence in pancreatic ductal adenocarcinoma. Pancreatic inflammation accelerates mutant Kras-driven tu......
期刊: NATURE CANCER, 2021; 2 (1)
Malignant solid tumors are characterized by aberrant vascularity that fuels the formation of an immune-hostile microenvironment and induces resistance......
期刊: NATURE CANCER, 2021; 2 (3)
Yang and colleagues perform a network system-pharmacology approach and clinical data integration, and identify LCK and BCL2 signaling as the molecular......
期刊: NATURE CANCER, 2021; 2 (2)
Garofano et al. use single-cell RNA-sequencing data to classify glioblastomas along a metabolic axis of mitochondrial and glycolytic/plurimetabolic st......
期刊: NATURE CANCER, 2020; 1 (2)
Tumor-initiating cells (TICs) are considered the culprits of cancer development and progression. Dysregulation of metastasis suppressor protein 1 (MTS......
期刊: NATURE CANCER, 2020; 1 (12)
Immune checkpoint blockade (ICB) has improved outcomes for patients with advanced cancer, but the determinants of response remain poorly understood. H......
期刊: NATURE CANCER, 2022; 3 (11)
Senolytics, drugs that kill senescent cells, have been proposed to improve the response to pro-senescence cancer therapies; however, this remains chal......