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A structural analysis of the hypoxia response network

期刊: PEERJ, 2021; 9 ()

Background. The hypoxia-inducible factor-1 (HIF-1) signaling pathway is an important topic in high-altitude medicine. Network analysis is a novel meth......

Potentially toxic metal(loid) distribution and migration in the bottom weathering profile of indigenous zinc smelting slag pile in clastic rock region

期刊: PEERJ, 2021; 9 ()

Background: There are contaminated by potentially toxic metal(loid)s (PTMs) that the surface soil and the weathering profiles around the indigenous zi......

Optimal extraction, purification and antioxidant activity of total flavonoids from endophytic fungi of Conyza blinii H. Lev

期刊: PEERJ, 2021; 9 ()

Background. Flavonoids are widely used in the market because of their antibacterial, antiviral, and antioxidant activities. But the production speed o......

Prediction and analysis of novel key genes ITGAX, LAPTM5, SERPINE1 in clear cell renal cell carcinoma through bioinformatics analysis

期刊: PEERJ, 2021; 9 ()

Background. Clear Cell Renal Cell Carcinoma (CCRCC) is the most aggressive subtype of Renal Cell Carcinoma (RCC) with high metastasis and recurrence r......

Artificial light source selection in seaweed production: growth of seaweed and biosynthesis of photosynthetic pigments and soluble protein

期刊: PEERJ, 2021; 9 ()

Seaweed growth is often limited by light. Artificial light supply has been well studied in terrestrial agriculture, however, much less is known about ......

Consequences of herbal mixture supplementation on milk performance, ruminal fermentation, and bacterial diversity in water buffaloes

期刊: PEERJ, 2021; 9 ()

This study was aimed to evaluate the potential of a herbal mixture (HM) to improve production performance, rumen fermentation, and milk fatty acid pro......

Cuffless blood pressure estimation based on haemodynamic principles: progress towards mobile healthcare

期刊: PEERJ, 2021; 9 ()

Background: Although cuff-sphygmomanometry is used worldwide in medical and healthcare fields, it is a fact that the use of an occlusive cuff to obtai......

Promoting effect of rapamycin on osteogenic differentiation of maxillary sinus membrane stem cells

期刊: PEERJ, 2021; 9 ()

Background. Stem cells located in the maxillary sinus membrane can differentiate into osteocytes. Our study aimed to evaluate the effect of rapamycin ......

Distribution of soil nutrients and erodibility factor under different soil types in an erosion region of Southeast China

期刊: PEERJ, 2021; 9 ()

Background. Soil erosion can affect the distribution of soil nutrients, which restricts soil productivity. However, it is still a challenge to underst......

Identification and expression pattern analysis of miRNAs in pectoral muscle during pigeon (Columba livia) development

期刊: PEERJ, 2021; 9 ()

MicroRNAs (miRNAs) are a group of crucial regulators in the process of animal growth and development. However, little is known about the expression an......

Combination of ferulic acid, ligustrazine and tetrahydropalmatine inhibits invasion and metastasis through MMP/TIMP signaling in endometriosis

期刊: PEERJ, 2021; 9 ()

Background: The design of the combination of ferulic acid, ligustrazine and tetrahydropalmatine (FLT) is inspired by the Chinese herbal prescription F......

Furongian (Jiangshanian) occurrences of radiodonts in Poland and South China and the fossil record of the Hurdiidae

期刊: PEERJ, 2021; 9 ()

The Furongian period represents an important gap in the fossil record of most groups of non-biomineralizing organisms, owing to a scarcity of Konserva......

Sequence analysis and mRNA expression of prolactin receptor gene isoforms in different tissues of sheep during lactation and the post-weaning period

期刊: PEERJ, 2021; 9 ()

Few studies onmRNAexpression of the prolactin receptor (PRLR) isoforms in different tissues of sheep were reported. The objective of this study was to......

Identification of miRNA-target gene regulatory networks in liver fibrosis based on bioinformatics analysis

期刊: PEERJ, 2021; 9 ()

Background. Liver cirrhosis is one of the leading causes of death worldwide. MicroRNAs (miRNAs) can regulate liver fibrosis, but the underlying mechan......

A molecular phylogeny of the Chinese Sinopoda spiders (Sparassidae, Heteropodinae): implications for taxonomy

期刊: PEERJ, 2021; 9 ()

Sinopoda spiders are a diverse group with limited dispersal ability. They are remarkably sympatric among related species, which often results in misid......

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