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Hesperetin inhibits foam cell formation and promotes cholesterol efflux in THP-1-derived macrophages by activating LXR alpha signal in an AMPK-dependent manner

期刊: JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY, 2021; 77 (3)

Cholesterol efflux from macrophages is the first step of reverse cholesterol transport (RCT), whose increase inhibits cholesterol accumulation and foa......

MiR-137 regulates low-intensity shear stress-induced human aortic endothelial cell apoptosis via JNK/AP-1 signaling

期刊: JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY, 2021; 77 (3)

The objective of this study is to evaluate the role of miR-137 in low-intensity shear stress-induced endoplasmic reticulum (ER) stress and cell apopto......

Role of the microRNA-29 family in myocardial fibrosis

期刊: JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY, 2021; 77 (3)

Myocardial fibrosis (MF) is an inevitable pathological process in the terminal stage of many cardiovascular diseases, often leading to serious cardiac......

LncRNA AFAP1-AS1 promotes M1 polarization of macrophages and osteogenic differentiation of valve interstitial cells

期刊: JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY, 2021; 77 (3)

Little is known about the biological functions and underlying mechanisms of long non-coding RNA AFAP1-AS1 in degenerative calcified aortic valve disea......

Autophagy blockage promotes the pyroptosis of ox-LDL-treated macrophages by modulating the p62/Nrf2/ARE axis

期刊: JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY, 2021; 77 (3)

Atherosclerosis, a chronic comprehensive cardiovascular disease, is characterized by the lipid infiltration, formation of foam cells derived from macr......

miR-455-5p regulates atrial fibrillation by targeting suppressor of cytokines signaling 3

期刊: JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY, 2021; 77 (3)

Atrial fibrillation (AF) is a condition that heart beats quaveringly or irregularly, which causes blood clots, heart failure, stroke, and other heart-......

Posttranslational modification of pyruvate kinase type M2 (PKM2): novel regulation of its biological roles to be further discovered

期刊: JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY, 2021; 77 (3)

PKM2, pyruvate kinase type M2, has been shown to play a key role in aerobic glycolysis and to regulate the malignant behaviors of cancer cells. Recent......

Strictosamide alleviates the inflammation in an acute ulcerative colitis (UC) model

期刊: JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY, ; ()

The ulcerative colitis (UC) is a typical inflammatory bowel disease (IBD) causing great damages, while strictosamide (STR) is a natural alkaloid that ......

Inhibition of HMGB1 reduced high glucose-induced BMSCs apoptosis via activation of AMPK and regulation of mitochondrial functions

期刊: JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY, ; ()

High mobility group box-1 (HMGB1) participates actively in oxidative stress damage, and the latter relates closely to diabetes and diabetic complicati......

The mechanism and prevention of mitochondrial injury after exercise

期刊: JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY, ; ()

With the development of society, physical activity has come to be an effective means by which people pursue good health to improve the quality of life......

The emerging role of circular RNAs in cardiovascular diseases

期刊: JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY, ; ()

Cardiovascular disease (CVD) is one of the vital causes of morbidity and mortality, and the number of deaths from CVD has increased worldwide. Circula......

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