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Emergency use of COVID-19 vaccines recommended by the World Health Organization (WHO) as of June 2021

期刊: DRUG DISCOVERIES AND THERAPEUTICS, 2021; 15 (4)

In December 2019, the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the outbreak of coronavirus disease 2019 (COVID-19), a......

Focal nodular hyperplasia mimicking hepatocellular adenoma and carcinoma in two cases

期刊: DRUG DISCOVERIES AND THERAPEUTICS, 2021; 15 (2)

Focal nodular hyperplasia (FNH) is a solid benign tumor of the liver, predominantly in young women. A correct diagnosis of FNH is essential for making......

Less is more: A novel single-tablet regimen with two-drugs, dolutegravir/lamivudine

期刊: DRUG DISCOVERIES AND THERAPEUTICS, 2021; 15 (4)

Combined antiretroviral therapy (cART) has significantly reduced human immunodeficiency virus (HIV) associated morbidity and mortality and turned HIV ......

Aducanumab: The first targeted Alzheimer's therapy

期刊: DRUG DISCOVERIES AND THERAPEUTICS, 2021; 15 (3)

Alzheimer's disease (AD) is an irreversible brain disorder associated with severe progressive dementia and is characterized by deposits of amyloid pla......

Next-generation COVID-19 vaccines: Opportunities for vaccine development and challenges in tackling COVID-19

期刊: DRUG DISCOVERIES AND THERAPEUTICS, 2021; 15 (3)

The ongoing COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global threat. Although non-pharma......

Novel anticancer drugs approved in 2020

期刊: DRUG DISCOVERIES AND THERAPEUTICS, 2021; 15 (1)

Cancer is still a major factor threatening human life around the world, and anticancer drugs remain a huge unmet clinical need. Here, we reviewed nove......

Molecular and immunological diagnosis of Monkeypox virus in the clinical laboratory

期刊: DRUG DISCOVERIES AND THERAPEUTICS, 2022; 16 (6)

The 2022 monkeypox outbreak outside Africa is ongoing. Cases have been reported in Hong Kong and Chongqing, China. In order to better prevent and cont......

Valemetostat: First approval as a dual inhibitor of EZH1/2 to treat adult T-cell leukemia/lymphoma

期刊: DRUG DISCOVERIES AND THERAPEUTICS, 2022; 16 (6)

Adult T-cell leukemia/lymphoma (ATL) is a mature T-cell lymphoma with a poor prognosis. Accumulating trimethylation of histone H3 lysine 27 (H3K27me3)......

Challenges in the screening and treatment of latent multidrug-resistant tuberculosis infection

期刊: DRUG DISCOVERIES AND THERAPEUTICS, 2022; 16 (2)

Individuals in close contact with multidrug-resistant tuberculosis (MDR-TB) patients are subject to an elevated risk of infection, and may develop lat......

Oral high-dose acetylcysteine: Effective against the Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)?

期刊: DRUG DISCOVERIES AND THERAPEUTICS, 2022; 16 (3)

The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a high rate of transmission and it exhibits immune escape char......

WRQ-2, a gemcitabine prodrug, reverses gemcitabine resistance caused by hENT1 inhibition

期刊: DRUG DISCOVERIES AND THERAPEUTICS, 2022; 16 (6)

Gemcitabine is widely used in the clinic as a first-line antitumor agent. However, intrinsic and acquired resistance hinders its wide clinical applica......

Xpert MTB/RIF Ultra in the auxiliary diagnosis of tuberculosis among people living with human immunodeficiency virus

期刊: DRUG DISCOVERIES AND THERAPEUTICS, 2022; 16 (6)

Clinical diagnosis of tuberculosis (TB) in people living with the human immunodeficiency virus (HIV) poses a challenge. The Xpert MTB/RIF Ultra (Ultra......

Prospects of contezolid (MRX-I) against multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis Comment

期刊: DRUG DISCOVERIES AND THERAPEUTICS, 2022; 16 (2)

Tuberculosis has become a great global public health threat. Compared with drug-susceptible tuberculosis (TB), the treatment regimens for multidrug-re......

Portal vein thrombosis as the first presentation of paroxysmal nocturnal hemoglobinuria

期刊: DRUG DISCOVERIES AND THERAPEUTICS, 2022; 16 (4)

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired clonal hematopoietic stem cell disorder, characterized by hemolytic anemia, bone marrow ......

Dating the origin and dispersal of global hepatitis B virus genotype C in humans

期刊: DRUG DISCOVERIES AND THERAPEUTICS, 2022; 16 (2)

Hepatitis B virus genotype C (HBV/C) is one of the most prevalent HBV strains worldwide, especially in the Western Pacific and the South-East Asia. Ho......

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