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Epigallocatechin gallate protects the human lens epithelial cell survival against UVB irradiation through AIF/endo G signalling pathways in vitro

期刊: CUTANEOUS AND OCULAR TOXICOLOGY, 2021; 40 (3)

Objective Oxidative stress has been recognised as an important mediator of apoptosis in lens epithelial cells. It also plays an important role in the ......

Optimization of the extraction conditions and dermal toxicity of oil body fused with acidic fibroblast growth factor (OLAF)

期刊: CUTANEOUS AND OCULAR TOXICOLOGY, 2021; 40 (3)

Introduction Oil body (OB), a subcellular organelle that stores oil in plant seeds, is considered a new transdermal drug delivery system. With the inc......

(-)-4-O-(4-O-beta-D-glucopyranosylcaffeoyl) quinic acid exerts anti-tumour effects against uveal melanoma through PI3K/AKT pathway

期刊: CUTANEOUS AND OCULAR TOXICOLOGY, 2021; 40 (2)

Purpose Uveal melanoma is the most common primary intraocular tumour in adults. There is no standard adjuvant treatment to prevent metastasis and no e......

Dermal toxicity, dermal irritation, and delayed contact sensitization evaluation of oil body linked oleosin-hEGF microgel emulsion via transdermal drug delivery for wound healing

期刊: CUTANEOUS AND OCULAR TOXICOLOGY, 2021; 40 (1)

Objective: The expression of therapeutic proteins in plant oil body bioreactors has attracted much attention. But its safety is not yet clear. This ar......

Methamphetamine causes acute toxicity in the retina of Balb/c mice

期刊: CUTANEOUS AND OCULAR TOXICOLOGY, 2020; 39 (2)

Purpose: As a powerful psychostimulant with high potential for abuse, methamphetamine (Meth) could cause neurological diseases. METH-induced ophthalmi......

The effect of sinomenine eye drops on experimental dry eye in mice

期刊: CUTANEOUS AND OCULAR TOXICOLOGY, 2020; 39 (4)

Objective To investigate the effect of topical sinomenine (SIN) on ocular surface damage in experimental dry eye in mice. Material and methods Experim......

Effects of a prostaglandin F2alpha derivative glaucoma drug on EGF expression and E-cadherin expression in a corneal epithelial cell line

期刊: CUTANEOUS AND OCULAR TOXICOLOGY, 2020; 39 (2)

Purpose: We examined the effects of travoprost on cell proliferation-related signals and E-cadherin expression in vitro and in situ in order to obtain......

Lysergic acid diethylamide causes mouse retinal damage by up-regulating p-JAK1/p-STAT1

期刊: CUTANEOUS AND OCULAR TOXICOLOGY, 2020; 39 (2)

Purpose: Lysergic acid diethylamide (LSD) is a powerful hallucinogen with high potential for abuse. There is far less known about its effects on the r......

Assessment of dermal safety of oil extracted fromPeriplaneta americana: acute dermal toxicity, irritation, and sensitization

期刊: CUTANEOUS AND OCULAR TOXICOLOGY, 2020; 39 (3)

Introduction:The American cockroach (Periplaneta americana) is used in traditional Chinese medicine.Periplaneta americana(P. americana) is rich in oil......

Ephedrine causes retinal damage in SD rats associating with JAK2/STAT3 pathway

期刊: CUTANEOUS AND OCULAR TOXICOLOGY, 2020; 39 (3)

Purpose Ephedrine has various side effects in the cardiovascular and nervous systems. However, the cellular mechanism of toxicity remains unknown, spe......

APRPG-modified nanoliposome loaded with miR-146a-5p inhibitor suppressed choroidal neovascularization by targeting endothelial cells

期刊: CUTANEOUS AND OCULAR TOXICOLOGY, 2020; 39 (4)

Introduction To explore the effect and mechanism of APRPG-modified nanoliposomes loaded with miR-146a-5p inhibitor (ANL-miR-146a-5p inhibitor) on endo......

Long-term systemic administration with low dose of 3,4-methylenedioxymethamphetamine causes photoreceptor cell damage in CD1 mice

期刊: CUTANEOUS AND OCULAR TOXICOLOGY, 2019; 38 (1)

Objective: As a powerful psychostimulant with high potential for abuse, 3,4-methylenedioxymethamphetamine (MDMA) causes long-lasting neurotoxicity. Th......

JIF:1.08

Toxicity assessment of six titanium dioxide nanoparticles in human epidermal keratinocytes

期刊: CUTANEOUS AND OCULAR TOXICOLOGY, 2019; 38 (1)

Purpose: The aim of this study was to evaluate and compare the toxicity of six different types of titanium dioxide (TiO2) nanoparticles (NP) on human ......

JIF:1.08

3,5-Dimethoxy-4-hydroxy myricanol ameliorates photoreceptor cell degeneration in Pde6b(rd10) mouse model

期刊: CUTANEOUS AND OCULAR TOXICOLOGY, 2019; 38 (1)

Introduction: Retinitis pigmentosa (RP) caused by the photoreceptor cell degeneration is currently incurable and leads to partial or complete blindnes......

JIF:1.08

Efficacy and safety of 2% supramolecular salicylic acid compared with 5% benzoyl peroxide/0.1% adapalene in the acne treatment: a randomized, split-face, open-label, single-center study

期刊: CUTANEOUS AND OCULAR TOXICOLOGY, 2019; 38 (1)

Background: Topical drugs for mild to moderate acne include adapalene (ADA) and benzoyl peroxide(BPO). Supramolecular salicylic acid (SSA), a modified......

JIF:1.08

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