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Overexpression of ribophorin II is required for viability of nasopharyngeal cancer cells by regulating JAK1/STAT3 activation

期刊: IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2021; 43 (4)

Objective This study aimed to elucidate the role of ribophorin II (RPN2) in nasopharyngeal cancer (NPC) cell survival and death. RPN2 expression was u......

VISTA-Ig ameliorates OXA-induced allergic dermatitis symptoms in mice

期刊: IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2021; 43 (3)

Background Allergic dermatitis (AD) is a chronic inflammatory skin disease that a variety of immune cells are involved in the progression of AD. Among......

Interference with lncRNA NEAT1 promotes the proliferation, migration, and invasion of trophoblasts by upregulating miR-411-5p and inhibiting PTEN expression

期刊: IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2021; 43 (3)

Background: Preeclampsia (PE) is an idiopathic hypertensive disorder of pregnancy, which is related to abnormal placental villi development. Our previ......

MiR-485-3p promotes proliferation of osteoarthritis chondrocytes and inhibits apoptosis via Notch2 and the NF-kappa B pathway

期刊: IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2021; 43 (3)

Context Osteoarthritis (OA) is one of the leading causes of disability worldwide. microRNAs (miRs) has been shown to be involved in multiple pathologi......

MicroRNA-30d-5p ameliorates lipopolysaccharide-induced acute lung injury via activating AMPK alpha

期刊: IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2021; 43 (4)

Objectives: Acute lung injury (ALI) is a devastating lung disease characterized by uncontrolled pulmonary inflammation and oxidative stress. Currently......

The efficacy and safety of Nivolumab combined with Ipilimumab in the immunotherapy of cancer: a meta-analysis

期刊: IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2021; 43 (3)

Background and Objective: Nivolumab and Ipilimumab are immune checkpoint inhibitors. The combination of Nivolumab and Ipilimumab has been reported to ......

Wogonoside attenuates the articular cartilage injury and the infiltration of Th1/Th2-type cytokines in papain-induced osteoarthritis in rat model via inhibiting the NF-kappa B and ERK1/2 activation

期刊: IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2021; 43 (3)

Objects Osteoarthritis is the most common joint disease and a major cause of functional limitation and pain in adults. This study aims to investigate ......

Glycyrrhizic acid, as an inhibitor of HMGB1, alleviates bleomycin-induced pulmonary toxicity in mice through the MAPK and Smad3 pathways

期刊: IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2021; 43 (4)

Aim High-mobility group box 1 (HMGB1) protein has been noticed particularly for its pivotal role in several pathologies. However, the relevance betwee......

Protective role of astragaloside IV in gastric cancer through regulation of microRNA-195-5p-mediated PD-L1

期刊: IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2021; 43 (4)

Aim Astragaloside IV (AS-IV) was reported to exert anti-cancer function in many cancers, but its actions in gastric cancer (GC) remain unclear. In the......

Dexmedetomidine inhibits inflammatory response and oxidative stress through regulating miR-205-5p by targeting HMGB1 in cerebral ischemic/reperfusion

期刊: IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2021; 43 (4)

Objective To investigate effects of dexmedetomidine (DEX) on miR-205-5p/HMGB1 axis in cerebral ischemic/reperfusion (I/R) injury. Methods Both in vivo......

Luteolin ameliorates inflammation and Th1/Th2 imbalance via regulating the TLR4/NF-kappa B pathway in allergic rhinitis rats

期刊: IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2021; 43 (3)

Objective Luteolin has an anti-allergic effect but its mechanism is not clear. This study attempted to determine the mechanisms of luteolin in rhiniti......

Anti-inflammatory effects of paeoniflorin caused by regulation of the hif1a/miR-210/caspase1/GSDMD signaling pathway in astrocytes: a novel strategy for hypoxia-induced brain injury in rats

期刊: IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2021; 43 (4)

Context: Hypoxia-induced injury is a classic symptom of obstructive sleep apnea hypopnea syndrome (OSAHS), which is a risk factor of various diseases,......

Circular RNA circ_0003420 mediates inflammation in sepsis-induced liver damage by downregulating neuronal PAS domain protein 4

期刊: IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, ; ()

Objective Our aim was to investigate whether circular RNA (circRNA) circ_0003420 mediates inflammation in sepsis-induced liver damage and to determine......

Prolongation of allograft survival by artemisinin treatment is associated with blockade of OX40-OX40L

期刊: IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, ; ()

Objectives It has been demonstrated that artemisinin (ART) possesses multiple immune modulatory effects. However, its role as immunosuppressant in all......

Immunomodulatory activity of puerarin in RAW264.7 macrophages and cyclophosphamide-induced immunosuppression mice

期刊: IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2021; 43 (2)

Context Puerarin, a natural isoflavone extracted from Radix puerariae, is famous for treating various cardiovascular and cerebrovascular diseases. How......

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