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Validation and update of a multivariable prediction model for the identification and management of patients at risk for hepatocellular carcinoma

期刊: CLINICAL PROTEOMICS, 2021; 18 (1)

Background A hepatocellular carcinoma (HCC) prediction model (ASAP), including age, sex, and the biomarkers alpha-fetoprotein and prothrombin induced ......

Quantitative proteomic analysis of aberrant expressed lysine acetylation in gastrointestinal stromal tumors

期刊: CLINICAL PROTEOMICS, 2021; 18 (1)

Background Gastrointestinal stromal tumor (GIST) is a common digestive tract tumor with high rate of metastasis and recurrence. Currently, we understa......

iTRAQ-based quantitative proteomic analysis of thoracic aortas from adult rats born to preeclamptic dams

期刊: CLINICAL PROTEOMICS, 2021; 18 (1)

Background: Preeclampsia and gestational hypertension can cause vascular function impairment in offspring. In our previous work, we described the prot......

Label-free proteomic analysis of serum exosomes from paroxysmal atrial fibrillation patients

期刊: CLINICAL PROTEOMICS, 2021; 18 (1)

Background: Atrial fibrillation (AF) is the most common cardiac heterogeneous rhythm disorder. It represents a major cause of mortality and morbidity,......

Identification of differentially expressed proteins and clinicopathological significance of HMGB2 in cervical cancer

期刊: CLINICAL PROTEOMICS, 2021; 18 (1)

To investigate the complexity of proteomics in cervical cancer tissues, we used isobaric tags for relative and absolute quantitation (iTRAQ)-based mas......

Global proteome profiling of human livers upon ischemia/reperfusion treatment

期刊: CLINICAL PROTEOMICS, 2021; 18 (1)

Hepatic ischemia/reperfusion (I/R) injury represents a major risk factor for liver transplantation and is related to graft dysfunction and acute/chron......

Proteomic analysis of decidua in patients with recurrent pregnancy loss (RPL) reveals mitochondrial oxidative stress dysfunction

期刊: CLINICAL PROTEOMICS, 2021; 18 (1)

Background Pregnancy is a complicated physiological process. The multifaceted regulation of maternal-fetal interface is of great importance for mainta......

Quantitative proteomics analysis of lysine 2-hydroxyisobutyrylation in IgA nephropathy

期刊: CLINICAL PROTEOMICS, 2021; 18 (1)

Background Protein posttranslational modification is an indispensable regulatory element that can fine-tune protein functions and regulate diverse cel......

Effects of cryopreservation and long-term culture on biological characteristics and proteomic profiles of human umbilical cord-derived mesenchymal stem cells

期刊: CLINICAL PROTEOMICS, 2020; 17 (1)

Background Human umbilical cord-derived MSCs (hUC-MSCs) have been identified as promising seeding cells in tissue engineering and clinical application......

New risk score for predicting steroid resistance in patients with focal segmental glomerulosclerosis or minimal change disease

期刊: CLINICAL PROTEOMICS, 2020; 17 (1)

Background Glucocorticosteroid is used for patients with primary nephrotic syndrome. This study aims to identify and validate that biomarkers can be u......

Human follicular fluid proteome reveals association between overweight status and oocyte maturation abnormality

期刊: CLINICAL PROTEOMICS, 2020; 17 (1)

Background Human follicular fluid (HFF), which is composed by essential proteins required for the follicle development, provides an important microenv......

Quantitative analysis of differentially expressed proteins in psoriasis vulgaris using tandem mass tags and parallel reaction monitoring

期刊: CLINICAL PROTEOMICS, 2020; 17 (1)

Background Psoriasis vulgaris(PV) is a chronic autoimmune inflammatory disease with epidermal hyperkeratosis and parakeratosis. Methods The study was ......

Chloride intracellular channel 4 participate in the protective effect of Ginkgolide B in MPP plus injured MN9D cells: insight from proteomic analysis

期刊: CLINICAL PROTEOMICS, 2020; 17 (1)

Background Ginkgolide B (GB), the extract ofG. bilobaleaves, has been shown to be protective against many neurological disorders, including Parkinson'......

A nomogram based on glycomic biomarkers in serum and clinicopathological characteristics for evaluating the risk of peritoneal metastasis in gastric cancer

期刊: CLINICAL PROTEOMICS, 2020; 17 (1)

Background: Peritoneal metastasis (PM) in gastric cancer (GC) remains an untreatable disease, and is difficult to diagnose preoperatively. Here, we ai......

A proteomic repertoire of autoantigens identified from the classic autoantibody clinical test substrate HEp-2 cells

期刊: CLINICAL PROTEOMICS, 2020; 17 (1)

Background Autoantibodies are a hallmark of autoimmune diseases. Autoantibody screening by indirect immunofluorescence staining of HEp-2 cells with pa......

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