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Nuezhenide Exerts Anti-Inflammatory Activity through the NF-kappa B Pathway

期刊: CURRENT MOLECULAR PHARMACOLOGY, 2021; 14 (1)

Background: Nuezhenide (NZD), an iridoid glycoside isolated from Ilex pubescens Hook. & Arn. var. kwangsiensis Hand.-Mazz., used as a traditional ......

CircRNA 001418 Promoted Cell Growth and Metastasis of Bladder Carcinoma via EphA2 by miR-1297

期刊: CURRENT MOLECULAR PHARMACOLOGY, 2021; 14 (1)

Background: Cancer is one of the major causes of human deaths at present. It is the leading cause of deaths in developed countries. Moreover, Circular......

Mitotherapy as a Novel Therapeutic Strategy for Mitochonclrial Diseases

期刊: CURRENT MOLECULAR PHARMACOLOGY, 2020; 13 (1)

Background: The mitochondrion is a multi-functional organelle that is mainly responsible for energy supply in the mammalian cells. Over 100 human dise......

The Role of Autophagy in Cancer Radiotherapy

期刊: CURRENT MOLECULAR PHARMACOLOGY, 2020; 13 (1)

Background: Autophagy, a pathway for lysosomal-mediated cellular degradation, is a catabolic process that recycles intracellular components to maintai......

miR-4319 Suppresses the Growth of Esophageal Squamous Cell Carcinoma Via Targeting NLRC5

期刊: CURRENT MOLECULAR PHARMACOLOGY, 2020; 13 (2)

Background: The functions of microRNAs (miRNAs) in cancer progression have been recognized in recent years. However, the role of miR-4319 in esophagea......

MiR-143 inhibits Osteoclastogenesis by Targeting RANK and NF-kappa B and MAPK Signaling Pathways

期刊: CURRENT MOLECULAR PHARMACOLOGY, 2020; 13 (3)

Objective: To explore the effect of miRNA-143 on osteoclast formation and provide new ideas for the treatment of osteoporosis. Methods: Mice macrophag......

Radio-Susceptibility of Nasopharyngeal Carcinoma: Focus on Epstein-Barr Virus, MicroRNAs, Long Non-Coding RNAs and Circular RNAs

期刊: CURRENT MOLECULAR PHARMACOLOGY, 2020; 13 (3)

Nasopharyngeal carcinoma (NPC) is a type of head and neck cancer. As a neoplastic disorder, NPC is a highly malignant squamous cell carcinoma that is ......

FAT10: Function and Relationship with Cancer

期刊: CURRENT MOLECULAR PHARMACOLOGY, 2020; 13 (3)

Posttranslational protein modifications arc known to be extensively involved in cancer, and a growing number of studies have revealed that the ubiquit......

miR-18a-3p Encourages Apoptosis of Chondrocyte in Osteoarthritis via HOXA1 Pathway

期刊: CURRENT MOLECULAR PHARMACOLOGY, 2020; 13 (4)

Background: Osteoarthritis is a disorder of joints featuring inflammation and degeneration of articular cartilage. Recently, miRs have been found to b......

Hepatic Stellate Cell: A Potential Target for Hepatocellular Carcinoma

期刊: CURRENT MOLECULAR PHARMACOLOGY, 2020; 13 (4)

Liver cancer is a leading cause of cancer-related death worldwide, in which hepatocellular carcinoma (HCC) accounts for the majority. Despite the prog......

MiR-597 Targeting 14-3-3 sigma Enhances Cellular Invasion and EMT in Nasopharyngeal Carcinoma Cells

期刊: CURRENT MOLECULAR PHARMACOLOGY, 2019; 12 (2)

Background: Alterations in microRNAs (miRNAs) are related to the occurrence of nasopharyngeal carcinoma (NPC) and play an important role in the molecu......

JIF:1.6

New Insights in Cannabinoid Receptor Structure and Signaling

期刊: CURRENT MOLECULAR PHARMACOLOGY, 2019; 12 (3)

Background: Cannabinoid has long been used for medicinal purposes. Cannabinoid signaling has been considered the therapeutic target for treating pain,......

JIF:1.6

H19/miR-675-5p Targeting SFN Enhances the Invasion and Metastasis of Nasalpharyngeal Cancer Cells

期刊: CURRENT MOLECULAR PHARMACOLOGY, 2019; 12 (4)

Aims: The aim is to study the role of miR-675-5p coded by long non-coding RNA H19 in the development of Nasopharyngeal Cancer (NPC) and whether miR-67......

JIF:1.6

In-vitro Pre-Treatment of Cancer Cells with TGF-beta 1: A Novel Approach of Tail Vein Lung Cancer Metastasis Mouse Model for Anti-Metastatic Studies

期刊: CURRENT MOLECULAR PHARMACOLOGY, 2019; 12 (4)

Background: Aggressive behavior of tumor metastasis comes from certain mutations, changes in cellular metabolic and signaling pathways that are majorl......

JIF:1.6

Anticancer Mechanism of Lobaplatin as Monotherapy and in Combination with Paclitaxel in Human Gastric Cancer

期刊: CURRENT MOLECULAR PHARMACOLOGY, 2018; 11 (4)

Objective: To explore the mechanism by which lobaplatin, as monotherapy and in combination with paclitaxel, inhibits the proliferation of human gastri......

JIF:1.6

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