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Mutational Landscape of Pirin and Elucidation of the Impact of Most Detrimental Missense Variants That Accelerate the Breast Cancer Pathways: A Computational Modelling Study

期刊: FRONTIERS IN MOLECULAR BIOSCIENCES, 2021; 8 ()

Pirin (PIR) protein is highly conserved in both prokaryotic and eukaryotic organisms. Recently, it has been identified that PIR positively regulates b......

The Potential Role of Extracellular Vesicles in COVID-19 Treatment: Opportunity and Challenge

期刊: FRONTIERS IN MOLECULAR BIOSCIENCES, 2021; 8 ()

SARS-CoV-2 infection has become an urgent public health concern worldwide, severely affecting our society and economy due to the long incubation time ......

In silico Screening of Natural Phytocompounds Towards Identification of Potential Lead Compounds to Treat COVID-19

期刊: FRONTIERS IN MOLECULAR BIOSCIENCES, 2021; 8 ()

COVID-19 is one of the members of the coronavirus family that can easily assail humans. As of now, 10 million people are infected and above two millio......

Meta-Analysis of the Diagnostic Value of Cell-free DNA for Renal Cancer

期刊: FRONTIERS IN MOLECULAR BIOSCIENCES, 2021; 8 ()

Cell-free DNA (cf-DNA) has been reported to represent a suitable material for liquid biopsy in the diagnosis and prognosis of various cancers. We perf......

Delayed Modeling Approach to Forecast the Periodic Behavior of SARS-2

期刊: FRONTIERS IN MOLECULAR BIOSCIENCES, 2021; 7 ()

The ongoing threat of Coronavirus is alarming. The key players of this virus are modeled mathematically during this research. The transmission rates a......

Meta-Analysis of the Diagnostic Value of Cell-free DNA for Renal Cancer

期刊: FRONTIERS IN MOLECULAR BIOSCIENCES, 2021; 8 ()

Cell-free DNA (cf-DNA) has been reported to represent a suitable material for liquid biopsy in the diagnosis and prognosis of various cancers. We perf......

Overcoming Chemoresistance via Extracellular Vesicle Inhibition

期刊: FRONTIERS IN MOLECULAR BIOSCIENCES, 2021; 8 ()

With the ever-growing number of cancer deaths worldwide, researchers have been working hard to identify the key reasons behind the failure of cancer t......

Chest CT Images for COVID-19: Radiologists and Computer-Based Detection

期刊: FRONTIERS IN MOLECULAR BIOSCIENCES, 2021; 8 ()

Background Characteristic chest computed tomography (CT) manifestation of 2019 novel coronavirus (COVID-19) was added as a diagnostic criterion in the......

A Novel Defined Risk Signature of the Ferroptosis-Related Genes for Predicting the Prognosis of Ovarian Cancer

期刊: FRONTIERS IN MOLECULAR BIOSCIENCES, 2021; 8 ()

Ferroptosis is an iron-dependent, regulated form of cell death, and the process is complex, consisting of a variety of metabolites and biological mole......

Advances and Insights of APC-Asef Inhibitors for Metastatic Colorectal Cancer Therapy

期刊: FRONTIERS IN MOLECULAR BIOSCIENCES, 2021; 8 ()

In Colorectal cancer (CRC), adenomatous polyposis coli (APC) directly interacts with the Rho guanine nucleotide exchange factor 4 (Asef) and releases ......

SphK2/S1P Promotes Metastasis of Triple-Negative Breast Cancer Through the PAK1/LIMK1/Cofilin1 Signaling Pathway

期刊: FRONTIERS IN MOLECULAR BIOSCIENCES, 2021; 8 ()

Background Triple-negative breast cancer (TNBC) features a poor prognosis, which is partially attributed to its high metastatic rate. However, there i......

Antibodies and Vaccines Target RBD of SARS-CoV-2

期刊: FRONTIERS IN MOLECULAR BIOSCIENCES, 2021; 8 ()

The novel human coronavirus, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which gives rise to the coronavirus disease 2019 (COVID-19)......

Quantitative Proteomics Analysis of FFPE Tumor Samples Reveals the Influences of NET-1 siRNA Nanoparticles and Sonodynamic Therapy on Tetraspanin Protein Involved in HCC

期刊: FRONTIERS IN MOLECULAR BIOSCIENCES, 2021; 8 ()

Hepatocellular carcinoma (HCC) poses a severe threat to human health. The NET-1 protein has been proved to be strongly associated with HCC proliferati......

Construction and External Validation of a Ferroptosis-Related Gene Signature of Predictive Value for the Overall Survival in Bladder Cancer

期刊: FRONTIERS IN MOLECULAR BIOSCIENCES, 2021; 8 ()

Purpose: To identify whether ferroptosis-related genes play predictive roles in bladder cancer patients and to develop a ferroptosis-related gene sign......

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