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Cationic Homopolymers Inhibit Spore and Vegetative Cell Growth of Clostridioides difficile

期刊: ACS INFECTIOUS DISEASES, 2021; 7 (5)

A wide range of synthetic polymers have been explored for antimicrobial activity. These materials usually contain both cationic and hydrophobic subuni......

Gallium Porphyrin and Gallium Nitrate Reduce the High Vancomycin Tolerance of MRSA Biofilms by Promoting Extracellular DNA-Dependent Biofilm Dispersion

期刊: ACS INFECTIOUS DISEASES, 2021; 7 (8)

Biofilms, structured communities of bacterial cells embedded in a self-produced extracellular matrix (ECM) which consists of proteins, polysaccharide ......

High-Throughput Screening of an FDA-Approved Drug Library Identifies Inhibitors against Arenaviruses and SARS-CoV-2

期刊: ACS INFECTIOUS DISEASES, 2021; 7 (6)

Arenaviruses are a large family of enveloped negative-strand RNA viruses that include several causative agents of severe hemorrhagic fevers. Currently......

MicroRNA-18b-5p Downregulation Favors Mycobacterium tuberculosis Clearance in Macrophages via HIF-1 alpha by Promoting an Inflammatory Response

期刊: ACS INFECTIOUS DISEASES, 2021; 7 (4)

The modulation of the interaction between macrophages and Mycobacterium tuberculosis (M.tb) through microRNA during M.tb infection is increasingly cap......

Membrane-Permeable Antibacterial Enzyme against Multidrug-Resistant Acinetobacter baumannii

期刊: ACS INFECTIOUS DISEASES, 2021; 7 (8)

Bacteriophage endolysins (lysins, or murein hydrolases) are enzymes that bacteriophages utilize to degrade the cell wall peptidoglycans (PG) and subse......

A Marine Antibiotic Kills Multidrug-Resistant Bacteria without Detectable High-Level Resistance

期刊: ACS INFECTIOUS DISEASES, 2021; 7 (4)

Antibiotic resistance nowadays is spreading much faster than the introduction of new antibiotics into clinical practice. There is an urgent need for p......

Quinoline and Quinazoline Derivatives Inhibit Viral RNA Synthesis by SARS-CoV-2 RdRp

期刊: ACS INFECTIOUS DISEASES, 2021; 7 (6)

Coronavirus disease 2019 (COVID-19) is a fatal respiratory illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The identif......

New Antimicrobial Peptides with Repeating Unit against Multidrug-Resistant Bacteria

期刊: ACS INFECTIOUS DISEASES, 2021; 7 (6)

With the aim of tackling the increasingly serious antimicrobial resistance and improving the clinical potential of AMPs, a facile de novo strategy was......

Diclazuril Inhibits Biofilm Formation and Hemolysis of Staphylococcus aureus

期刊: ACS INFECTIOUS DISEASES, 2021; 7 (6)

Biofilm formation and hemolysis induced by Staphylococcus aureus are closely related to pathogenicity. However, no drugs exist to inhibit biofilm form......

Resveratrol Attenuates Meningitic Escherichia coli-Mediated Blood-Brain Barrier Disruption

期刊: ACS INFECTIOUS DISEASES, 2021; 7 (4)

Meningitic Escherichia coli can infiltrate the central nervous system (CNS), consequently increasing the levels of proinflammatory cytokines and chemo......

RegX3 Controls Glyoxylate Shunt and Mycobacteria Survival by Directly Regulating the Transcription of Isocitrate Lyase Gene in Mycobacterium smegmatis

期刊: ACS INFECTIOUS DISEASES, 2021; 7 (4)

The glyoxylate shunt is a pathway associated with the assimilation of fatty acids and is implicated in the resistance of M. tuberculosis (Mtb). Isocit......

Human Cathelicidin Inhibits SARS-CoV-2 Infection: Killing Two Birds with One Stone

期刊: ACS INFECTIOUS DISEASES, 2021; 7 (6)

SARS-CoV-2 infection begins with the association of its spike 1 (S1) protein with host angiotensin-converting enzyme-2 (ACE2). Targeting the interacti......

Recent Insights into Emerging Coronavirus: SARS-CoV-2

期刊: ACS INFECTIOUS DISEASES, 2021; 7 (6)

The SARS-CoV-2 outbreak that emerged at the end of 2019 has affected more than 58 million people with more than 1.38 million deaths and has had an inc......

Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439

期刊: ACS INFECTIOUS DISEASES, 2021; 7 (7)

OZ439 is a potent synthetic ozonide evaluated for the treatment of uncomplicated malaria. The metabolite profile of OZ439 was characterized in vitro u......

Sialylated Lipooligosaccharide Contributes to Glaesserella parasuis Penetration of Porcine Respiratory Epithelial Barrier

期刊: ACS INFECTIOUS DISEASES, 2021; 7 (3)

Pathogens utilize various mechanisms to escape host immunological surveillance, break down different tissue barriers, and cause infection. Sialylation......

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