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Chlorinated briarane diterpenoids from octocoral Briareum stechei (Kukenthal, 1908)

期刊: TETRAHEDRON LETTERS, 2021; 69 ()

Six 6-chlorine-containing briarane analogues, including two new compounds, briarenols U (1) and V (2), as well as four known metabolites, solenolides ......

Rhodium(III)-catalyzed regioselective C-H nitrosation/annulation of unsymmetrical azobenzenes to synthesize benzotriazole N-oxides via a Rh-III/Rh-III redox-neutral pathway

期刊: TETRAHEDRON LETTERS, 2021; 72 ()

A Rh(III)-catalyzed regioselective C-H nitrosation/annulation reaction of unsymmetrical azobenzenes with [NO][BF4] has been developed to achieve high-......

Scopariusicide C, a novel cyclobutene-containing meroditerpenoid from artificially cultivated Isodon scoparius

期刊: TETRAHEDRON LETTERS, 2021; 73 ()

Scopariusicide C (1), a novel ent-clerodane-based meroditerpenoid was isolated from artificially cultivated Isodon scoparius. An oxygen insertion reac......

Green synthesis of 4-organylselanyl-1H-pyrazoles through electrochemical cross-dehydrogenative coupling of 1H-pyrazoles and diorganyl diselenides

期刊: TETRAHEDRON LETTERS, 2021; 77 ()

An atom-economical and efficient method for synthesizing 4-organylselanyl-1H-pyrazoles through electrochemical cross-dehydrogenation coupling of N-uns......

Rapid entry to bispiro heterocycles merging five pharmacophores using phase-transfer catalysis

期刊: TETRAHEDRON LETTERS, 2021; 78 ()

A practical 1,3-dipolar [3 + 2] cycloaddition of N-2,2,2-trifluoroethylisatin ketimines and (Z)-4-((chro-mone-3-yl)methylene)oxazolones under phase-tr......

Development of novel synthetic method of natural antimicrobial peptide TP4

期刊: TETRAHEDRON LETTERS, 2021; 79 ()

Antimicrobial peptides are an important part of the natural immune system. According to reports, the antimicrobial peptide piscidins have a very signi......

A thiol-responsive and self-immolative podophyllotoxin prodrug for cancer therapy

期刊: TETRAHEDRON LETTERS, 2021; 71 ()

To improve drug efficiency and reduce side effects in cancer therapy, precision therapy with small molecular prodrugs is urgently needed. Podophylloto......

Solvent-dependent metal-free chemoselective synthesis of benzimidazoles and 1,3,5-triarylbenzenes from 2-amino anilines and aryl alkyl ketones catalyzed by I-2

期刊: TETRAHEDRON LETTERS, 2021; 70 ()

A solvent-dependent I-2-catalyzed chemoselective reaction was developed for the synthesis of benzimidazoles and 1,3,5-triarylbenzenes via the annulati......

Pd(II)/(S)-t-BuPyOx-catalyzed asymmetric addition of arylboronic acids to N-sulfonyl-arylaldimines

期刊: TETRAHEDRON LETTERS, 2021; 72 ()

The asymmetric version of Pd(II)/bipyridine-catalyzed nucleophilic addition of arylboronic acids to N-sulfonyl arylaldimines was developed, and excell......

Enantioselective synthesis of C3 substituted benzofuroindolines via catalytic asymmetric [3+2] cyclization of 3-substituted indoles with p-benzoquinones

期刊: TETRAHEDRON LETTERS, 2021; 76 ()

An efficient catalytic asymmetric [3 + 2] cyclization of 3-substituted indoles with p-benzoquinones has been realized using a binol-chiral phosphoric ......

Copper catalyzed aerobic oxidative amination of 3,4-dihydroquinoxalin-2(1H)-ones

期刊: TETRAHEDRON LETTERS, 2021; 78 ()

A copper catalyzed aerobic sp(3) C-H amination of 3,4-dihydroquinoxalin-2(1H)-ones is developed. This protocol provides a concise method to access 3-a......

Cobalt-catalyzed C-H activation of N-carbamoyl indoles or benzamides with maleimides: Synthesis of imidazo[1,5-a]indole- or isoindolone-incorporated spirosuccinimides

期刊: TETRAHEDRON LETTERS, 2021; 70 ()

A cobalt-catalyzed C-H activation/cyclization of N-carbamoyl indole/benzamides with maleimides assisted by pyridinylmethylamine under mild reaction co......

Copper-catalyzed synthesis of CN-containing chroman-4-ones via intramolecular radical cascade acyl-cyanation reaction

期刊: TETRAHEDRON LETTERS, 2021; 72 ()

A copper-catalyzed intramolecular radical cascade acyl-cyanation to synthesize cyano-containing chroman-4-ones has been developed. A series of CN-subs......

Rh(III)-catalyzed selective C7-H functionalization of indolines with 1,3-enynes enables access to six-membered 1,7-fused indolines

期刊: TETRAHEDRON LETTERS, 2021; 72 ()

We described herein a Rh(III)-catalyzed C7-selective C-H activation/annulation of indolines with 1,3-enynes to efficiently access various privileged 1......

Phenyl(trifluoroethyl)iodonium-triflate-initiated ring-opening polymerization of tetrahydrofuran

期刊: TETRAHEDRON LETTERS, 2021; 73 ()

A catalyst- and additive-free ring-opening polymerization of tetrahydrofuran initiated by phenyl(trifluoroethyl)iodonium triflate ([PhICH2CF3][OTf]) w......

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