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Identification of HLA-A*0201-restricted CTL Epitopes for MLAA-34-specific Immunotherapy for Acute Monocytic Leukemia

期刊: JOURNAL OF IMMUNOTHERAPY, 2021; 44 (4)

Our previous research has shown that monocytic leukemia-associated antigen-34 (MLAA-34) was a novel antiapoptotic molecule with unique expression in a......

PMEL as a Prognostic Biomarker and Negatively Associated With Immune Infiltration in Skin Cutaneous Melanoma (SKCM)

期刊: JOURNAL OF IMMUNOTHERAPY, 2021; 44 (6)

Premelanosome protein (PMEL) is crucial for the formation of melanosomal fibrils through the transition from stage I to stage II melanosomes. It was u......

Development of a Tetravalent T-Cell Engaging Bispecific Antibody Against Glypican-3 for Hepatocellular Carcinoma

期刊: JOURNAL OF IMMUNOTHERAPY, 2021; 44 (3)

Cancer therapies benefit from accelerated development of biotechnology, and many immunotherapeutic strategies spring up including vaccines, the immune......

Effects of Antibiotic Use on Outcomes in Cancer Patients Treated Using Immune Checkpoint Inhibitors: A Systematic Review and Meta-Analysis

期刊: JOURNAL OF IMMUNOTHERAPY, 2021; 44 (2)

Antibiotic (ATB) use seems to negatively affect the outcomes of immune checkpoint inhibitors (ICIs). The aim of this review is to clarify whether ATB ......

High VISTA Expression Correlates With a Favorable Prognosis in Patients With Colorectal Cancer

期刊: JOURNAL OF IMMUNOTHERAPY, 2021; 44 (1)

Colorectal cancer (CRC) is the third most common malignancy worldwide. The novel immune checkpoint V-domain Ig suppressor of T-cell activation (VISTA)......

Identification of Different Form Tim-3 Proteins by a Unique Set of Tim-3 Monoclonal Antibodies

期刊: JOURNAL OF IMMUNOTHERAPY, 2020; 43 (2)

T-cell immunoglobulin and mucin domain-3 (Tim-3) has been suggested to be a critical immune checkpoint target for cancer immunotherapy. However, limit......

Positive Status of Epstein-Barr Virus as a Biomarker for Gastric Cancer Immunotherapy: A Prospective Observational Study

期刊: JOURNAL OF IMMUNOTHERAPY, 2020; 43 (4)

Immunotherapy has exhibited promising but controversial results in gastric cancer; determining criteria for choosing the appropriate target population......

Paraneoplastic Encephalitis and Enteric Neuropathy Associated With Anti-Hu Antibody in a Patient Following Immune-checkpoint Inhibitor Therapy

期刊: JOURNAL OF IMMUNOTHERAPY, 2020; 43 (5)

Paraneoplastic neurological syndromes (PNSs) are uncommon complications of immune-checkpoint inhibitor (ICI) therapy. This article reports a case of p......

Study on the Expression Levels and Clinical Significance of PD-1 and PD-L1 in Plasma of NSCLC Patients

期刊: JOURNAL OF IMMUNOTHERAPY, 2020; 43 (5)

As new members of the CD28/B7 costimulatory superfamily, PD-1 (programmed cell death 1) and its ligand PD-L1 (programmed cell death ligand 1) mediate ......

Efficacy of Pembrolizumab Monotherapy in Patients With or Without Brain Metastases From Advanced Non-Small Cell Lung Cancer With a PD-L1 Expression >= 50%

期刊: JOURNAL OF IMMUNOTHERAPY, 2020; 43 (9)

The authors conducted a multicenter retrospective study on the outcome of programmed death-ligand 1 tumor proportion score >= 50% advanced non-smal......

TNF-a Is a Potent Stimulator of Tc9-Cell Differentiation

期刊: JOURNAL OF IMMUNOTHERAPY, 2020; 43 (9)

Tumor-specific Tc9 cells exhibit an excellent antitumor potential in tumor immunotherapy. Identification of factors that contribute to Tc9-cell differ......

Radiation Priming Chimeric Antigen Receptor T-Cell Therapy in Relapsed/Refractory Diffuse Large B-Cell Lymphoma With High Tumor Burden

期刊: JOURNAL OF IMMUNOTHERAPY, 2020; 43 (1)

Chimeric antigen receptor T-cell (CAR-T) therapy demonstrates impressive efficacy in relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL). ......

CAIX-specific CAR-T Cells and Sunitinib Show Synergistic Effects Against Metastatic Renal Cancer Models

期刊: JOURNAL OF IMMUNOTHERAPY, 2020; 43 (1)

Treatment with chimeric antigen receptor-modified T cell (CAR-T) has demonstrated promising therapeutic efficacy in hematologic malignancies. However,......

Advanced Non-Small Cell Lung Cancer Patients With Low Tumor Mutation Burden Might Derive Benefit From Immunotherapy

期刊: JOURNAL OF IMMUNOTHERAPY, 2020; 43 (6)

The aim of this study is to investigate the association between tumor mutation burden (TMB) and survival in non-small cell lung cancer (NSCLC) patient......

BCMA-targeting Bispecific Antibody That Simultaneously Stimulates NKG2D-enhanced Efficacy Against Multiple Myeloma

期刊: JOURNAL OF IMMUNOTHERAPY, 2020; 43 (6)

B-cell maturation antigen (BCMA) is a highly plasma cell-selective protein expressed on malignant plasma cells of patients with multiple myeloma (MM),......

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