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Nanoemulsion for Improving the Oral Bioavailability of Hesperetin: Formulation Optimization and Absorption Mechanism

期刊: JOURNAL OF PHARMACEUTICAL SCIENCES, 2021; 110 (6)

This study aimed to prepare a nanoemulsion vehicle to improve the oral bioavailability of hesperetin. The pseudo-ternary phase diagrams and the RSM we......

Optical Density Value and Ratio as Novel Indexes for Nanoemulsion Sterile Filtration Process Control or Characterization

期刊: JOURNAL OF PHARMACEUTICAL SCIENCES, 2021; 110 (6)

Sterile filtration is an effective method to remove any microorganisms present during nanoemulsion preparation. However, it lacks effective control pa......

Polymeric Lipid Hybrid Nanoparticles as a Delivery System Enhance the Antitumor Effect of Emodin in Vitro and in Vivo

期刊: JOURNAL OF PHARMACEUTICAL SCIENCES, 2021; 110 (8)

This study aimed to evaluate the therapeutic efficacy of Emodin-loaded polymer lipid hybrid nanoparticles (E-PLNs) for breast cancer. The size, Zeta p......

Polyketal Nanoparticles Co-Loaded With miR-124 and Ketoprofen for Treatment of Rheumatoid Arthritis

期刊: JOURNAL OF PHARMACEUTICAL SCIENCES, 2021; 110 (5)

Ketoprofen, a non-steroidal anti-inflammatory drug, can effectively relieve pain associated with arthritis, and microRNA-124 (miR-124) can inhibit the......

Improvement of Oral Bioavailability and Anti-Tumor Effect of Zingerone Self-Microemulsion Drug Delivery System

期刊: JOURNAL OF PHARMACEUTICAL SCIENCES, 2021; 110 (7)

This study sought to prepare a self-microemulsion drug delivery system containing zingerone (ZSMEDDS) to improve the low oral bioavailability of zinge......

Coamorphous System of Florfenicol-Oxymatrine for Improving the Solubility and Dissolution Rate of Florfenicol: Preparation, Characterization and Molecular Dynamics Simulation

期刊: JOURNAL OF PHARMACEUTICAL SCIENCES, 2021; 110 (6)

Coamorphous system has proved to be an effective approach to improve the solubility of BCSII drugs. Florfenicol (FF) is a widely used veterinary antib......

Anti-CD19 mAb modified mesoporous titanium dioxide as exclusively targeting vector for efficient B-lymphoblastic leukemia therapy

期刊: JOURNAL OF PHARMACEUTICAL SCIENCES, 2021; 110 (7)

B lymphoblastic leukemia (B-LL) is a clonal hematopoietic stem cell neoplasm derived from B-cell progenitors, which mainly occurs in children and adol......

Synthesis, Stability, and Anti-Tumour Activity of a New Category of "Stapled" Antisense Oligonucleotides with Stimuli-Responsive Feature

期刊: JOURNAL OF PHARMACEUTICAL SCIENCES, 2021; 110 (9)

The development of nucleic acid drugs with unique structures and mechanisms has stimulated great research interest. Herein, we report a general strate......

Fabrication of Rapidly Separable Microneedles for Transdermal Delivery of Metformin on Diabetic Rats

期刊: JOURNAL OF PHARMACEUTICAL SCIENCES, 2021; 110 (8)

In this work, the rapidly separable microneedles (MNs) consisted of needle-tips and supporting bases have been fabricated by a step-by-step coating me......

New Delivery Route of Gambogic Acid Via Skin for Topical Targeted Therapy of Cutaneous Melanoma and Reduction of Systemic Toxicity

期刊: JOURNAL OF PHARMACEUTICAL SCIENCES, 2021; 110 (5)

Cutaneous melanoma is the deadliest form of skin cancer, and gambogic acid (GA) exhibits potent anti-melanoma activity. However, clinical application ......

Potential Determinants for Metabolic Fates and Inhibitory Effects of Isobavachalcone Involving in Human Cytochrome P450, UDP-Glucuronosyltransferase Enzymes, and Efflux Transporters

期刊: JOURNAL OF PHARMACEUTICAL SCIENCES, 2021; 110 (5)

Isobavachalcone, a naturally occurring chalcone in Psoralea corylifolia, posses many biological properties including anticancer, antiplatelet, and ant......

Study on the Influencing Factors of Hypoglycemic Effect of Folate Targeted Polymersomes Encapsulating Insulin

期刊: JOURNAL OF PHARMACEUTICAL SCIENCES, 2021; 110 (5)

Purpose: To study the effects of the density of folic acid (FA) on the hypoglycemic ability of FA-targeted polymersomes as oral insulin carriers. Also......

Influence of drug-carrier compatibility and preparation method on the properties of paclitaxel-loaded lipid liquid crystalline nanoparticles

期刊: JOURNAL OF PHARMACEUTICAL SCIENCES, 2021; 110 (7)

The main objective of this paper is to elucidate the influence of drug-carrier compatibility and preparation method on the properties of Paclitaxel (P......

Vortioxetine Derivatives with Amino Acid as Promoiety: Synthesis, Activity, Stability and Preliminary Pharmacokinetic Study

期刊: JOURNAL OF PHARMACEUTICAL SCIENCES, 2021; 110 (8)

Vortioxetine (Vot) is an effective antidepressant with unique mechanisms exerting multi-target effects. However, severe side-effects such as nausea an......

Synthesis of gamma Phase and Amorphous Solid Dispersion of Glycine from a-Glycine During the Solvent-Free Ball Milling Process

期刊: JOURNAL OF PHARMACEUTICAL SCIENCES, 2021; 110 (9)

Nano alpha-glycine crystals, gamma-glycine crystals, and amorphous solid dispersion (ASD) of glycine were prepared through solvent-free ball milling o......

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