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Fast OCT image enhancement method based on the sigmoid-energy conservation equation

期刊: BIOMEDICAL OPTICS EXPRESS, 2021; 12 (4)

Optical coherence tomography (OCT) is an important medical diagnosis technology, but OCT images are inevitably interfered by speckle noise and other f......

Combination of pathological and spectroscopic characterization to promote diagnosis of retinal pigment epithelium-Bruch?s membrane complex in a diabetic rat model

期刊: BIOMEDICAL OPTICS EXPRESS, 2021; 12 (4)

Diabetic retinopathy (DR) is a common condition of diabetes, and approaches to detecting early DR using the unique characteristics of the retinal pigm......

Centimeter-scale wide-field-of-view laser-scanning photoacoustic microscopy for subcutaneous microvasculature in vivo

期刊: BIOMEDICAL OPTICS EXPRESS, 2021; 12 (5)

We developed a simple and compact laser-scanning photoacoustic microscopy (PAM) for imaging large areas of subcutaneous microvasculature in vivo. The ......

Diagnosis and staging of multiple myeloma using serum-based laser-induced breakdown spectroscopy combined with machine learning methods

期刊: BIOMEDICAL OPTICS EXPRESS, 2021; 12 (6)

Diagnosis and staging of multiple myeloma (MM) have been achieved using serum based laser-induced breakdown spectroscopy (LIBS) in combination with ma......

Organelle-specific phase contrast microscopy enables gentle monitoring and analysis of mitochondrial network dynamics

期刊: BIOMEDICAL OPTICS EXPRESS, 2021; 12 (7)

Mitochondria are delicate organelles that play a key role in cell fate. Current research methods rely on fluorescence labeling that introduces stress ......

Real-time noise reduction based on ground truth free deep learning for optical coherence tomography

期刊: BIOMEDICAL OPTICS EXPRESS, 2021; 12 (4)

Optical coherence tomography (OCT) is a high-resolution non-invasive 3D imaging modality, which has been widely used for biomedical research and clini......

Method for parametric imaging of attenuation by intravascular optical coherence tomography

期刊: BIOMEDICAL OPTICS EXPRESS, 2021; 12 (4)

Catheter-based intravascular optical coherence tomography (IVOCT) is a powerful imaging modality for visualization of atherosclerosis with high resolu......

Label-free identification of human coronary atherosclerotic plaque based on a three-dimensional quantitative assessment of multiphoton microscopy images

期刊: BIOMEDICAL OPTICS EXPRESS, 2021; 12 (5)

The rupture of coronary atherosclerotic plaque (CAP) and the resulting intracoronary thrombosis account for most acute coronary syndromes. Thus, the e......

Simulations of fluorescence imaging in the oral cavity

期刊: BIOMEDICAL OPTICS EXPRESS, 2021; 12 (7)

We describe an end-to-end image systems simulation that models a device capable of measuring fluorescence in the oral cavity. Our software includes a ......

Quantification of blood flow index in diffuse correlation spectroscopy using long short-term memory architecture

期刊: BIOMEDICAL OPTICS EXPRESS, 2021; 12 (7)

Diffuse correlation spectroscopy (DCS) is a noninvasive technique that derives blood flow information from measurements of the temporal intensity fluc......

Artificial intelligence-augmented, label-free molecular imaging method for tissue identification, cancer diagnosis, and cancer margin detection

期刊: BIOMEDICAL OPTICS EXPRESS, 2021; 12 (9)

Label-free high-resolution molecular and cellular imaging strategies for intraoperative use are much needed, but not yet available. To fill this void,......

Single-scan HiLo with line-illumination strategy for optical section imaging of thick tissues

期刊: BIOMEDICAL OPTICS EXPRESS, 2021; 12 (4)

Optical sectioning has been widely employed for inhibiting out-of-focus backgrounds in three-dimensional (3D) imaging of biological samples. However, ......

Tissue self-attention network for the segmentation of optical coherence tomography images on the esophagus

期刊: BIOMEDICAL OPTICS EXPRESS, 2021; 12 (5)

Automatic segmentation of layered tissue is the key to esophageal optical coherence tomography (OCT) image processing. With the advent of deep learnin......

Dec-DISCO: decolorization DISCO clearing for seeing through the biological architectures of heme-rich organs

期刊: BIOMEDICAL OPTICS EXPRESS, 2021; 12 (9)

The tissue optical clearing technique plays an important role in three-dimensional (3D) visualization of large tissues. As a typical solvent-based cle......

Unveiling osteosarcoma responses to DAPT combined with cisplatin by using confocal Raman microscopy

期刊: BIOMEDICAL OPTICS EXPRESS, 2021; 12 (9)

The aim of this study was to clarify the dose- and time-dependent effect of the.-secretase inhibitor (DAPT) combined with cisplatin on osteosarcoma (O......

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