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A novel global transcriptional perturbation target identified by forward genetics reprograms Vibrio natriegens for improving recombinant protein production

期刊: ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2021; 53 (9)

Vibrio natriegens is known to be the fastest-growing free-living bacterium with the potential to be a novel protein expression system other than Esche......

Evaluation of the immunomodulatory effects of C9-13-CPs in macrophages

期刊: ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2021; 53 (9)

Short-chain chlorinated paraffins (SCCPs) have been listed as a new class of persistent organic pollutants by the Stockholm Convention. SCCPs exhibit ......

SCM-198 ameliorates endometrial inflammation via suppressing the LPS-JNK- cJUN/cFOS-TLR4-NF-kappa B pathway

期刊: ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2021; 53 (9)

Endometritis is an inflammatory disease of the endometrium, which is responsible for endometrial dysfunction, decidualization failure, and increased i......

Nsp2 has the potential to be a drug target revealed by global identification of SARS-CoV-2 Nsp2-interacting proteins

期刊: ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2021; 53 (9)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global health threat since December 2019, and there is still no highly effec......

Mesenchymal stem cell-derived exosomal miR-21a-5p promotes M2 macrophage polarization and reduces macrophage infiltration to attenuate atherosclerosis

期刊: ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2021; 53 (9)

Atherosclerosis (AS) is the main pathological basis for ischemic cardiovascular and cerebrovascular diseases. Mesenchymal stem cell (MSC)-derived exos......

Silencing of ER-resident oxidoreductase PDIA3 inhibits malignant biological behaviors of multidrug-resistant gastric cancer

期刊: ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2021; 53 (9)

Glycosylation is a common posttranslational modification of proteins, which plays a role in the malignant transformation, growth, progression, chemore......

lncRNA NEAT1 promotes the Taxol resistance of breast cancer via sponging the miR-23a-3p-FOXA1 axis

期刊: ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2021; 53 (9)

Breast cancer is the most prevalent malignancy among women worldwide. Paclitaxel (Taxol) is a widely applied chemotherapeutic agent against breast can......

miR-100-5p in human umbilical cord mesenchymal stem cell-derived exosomes mediates eosinophilic inflammation to alleviate atherosclerosis via the FZD5/Wnt/beta-catenin pathway

期刊: ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2021; 53 (9)

Exosomes derived from human umbilical cord mesenchymal stem cells (hUCMSC-Ex) play important roles in immune and inflammation diseases. However, the r......

Retardant effect of dihydroartemisinin on ulcerative colitis in a JAK2/STAT3-dependent manner

期刊: ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2021; 53 (9)

Dihydroartemisinin (DHA) is a semi-synthetic derivative and the main active metabolite of artemisinin. The purpose of this study was to investigate th......

Glucagon-like peptide-1 attenuates cardiac hypertrophy via the AngII/AT1R/ACE2 and AMPK/mTOR/p70S6K pathways

期刊: ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2021; 53 (9)

Glucagon-like peptide-1 (GLP-1), a novel type of glucose-lowering agent, has been reported to exert cardioprotective effects. However, the cardioprote......

Omega-3 polyunsaturated fatty acids ameliorated inflammatory response of mammary epithelial cells and mammary gland induced by lipopolysaccharide

期刊: ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2021; 53 (9)

Omega-3 polyunsaturated fatty acids (n-3 PUFAs), essential fatty acids for humans and animals, have been reported to play a beneficial role in a varie......

Dexmedetomidine maintains blood-brain barrier integrity by inhibiting Drp1-related endothelial mitochondrial dysfunction in ischemic stroke

期刊: ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2021; 53 (9)

Stroke is the second leading cause of death and long-term disability worldwide, which lacks effective treatment. Perioperative stroke is associated wi......

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