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Pleural biomarkers in diagnostics of malignant pleural effusion: a narrative review

期刊: TRANSLATIONAL LUNG CANCER RESEARCH, 2021; 10 (3)

Although cytology and pleural biopsy of pleural effusion (PE) are the gold standards for diagnosing malignant pleural effusion (MPE), these tools' dia......

Titin mutation in circulatory tumor DNA is associated with efficacy to immune checkpoint blockade in advanced non-small cell lung cancer

期刊: TRANSLATIONAL LUNG CANCER RESEARCH, 2021; 10 (3)

Background: Only a fraction of patients with advanced non-small cell lung cancer (NSCLC) respond well to immune checkpoint blockade (ICB) therapy. Her......

Apatinib with etoposide capsules as a third- or further-line therapy for extensive-stage small cell lung cancer: an open-label, multicenter, single-arm phase II trial

期刊: TRANSLATIONAL LUNG CANCER RESEARCH, 2021; 10 (2)

Background: Patients with extensive-stage small-cell lung cancer (ES-SCLC) have a particularly poor prognosis. And the treatment options for patients ......

Consistency of recommendations for the diagnosis and treatment of non-small cell lung cancer: a systematic review

期刊: TRANSLATIONAL LUNG CANCER RESEARCH, 2021; 10 (6)

Background: To systematically assess the consistency of recommendations regarding diagnosis and treatment of non-small cell lung cancer (NSCLC) in cli......

Segmental resection is associated with decreased survival in patients with stage IA non-small cell lung cancer with a tumor size of 21-30 mm

期刊: TRANSLATIONAL LUNG CANCER RESEARCH, 2021; 10 (2)

Background: The feasibility of segmental resection for early-stage non-small cell lung cancer (NSCLC) is still controversial. This study aimed to comp......

Increased detection of circulating tumor DNA by short fragment enrichment

期刊: TRANSLATIONAL LUNG CANCER RESEARCH, 2021; 10 (3)

Background: Circulating cell-free DNA (cfDNA) detection for non-invasive diagnosis requires higher sensitivity and accuracy due to the low circulating......

PD-1 restrains IL-17A production from gamma delta T cells to modulate acute radiation-induced lung injury

期刊: TRANSLATIONAL LUNG CANCER RESEARCH, 2021; 10 (2)

Background: Combining radiotherapy (RT) with programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) inhibitors has been shown to enhance anti-tum......

Deep sequencing reveals the genomic characteristics of lung adenocarcinoma presenting as ground-glass nodules (GGNs)

期刊: TRANSLATIONAL LUNG CANCER RESEARCH, 2021; 10 (3)

Background: The concept of multi-step progression from atypical adenomatous hyperplasia (AAH) to invasive adenocarcinoma (ADC) has been proposed, and ......

Role of lymphatic endothelial cells in the tumor microenvironment-a narrative review of recent advances

期刊: TRANSLATIONAL LUNG CANCER RESEARCH, 2021; 10 (5)

Background: As lymphatic vessel is a major route for solid tumor metastasis, they are considered an essential part of tumor drainage conduits. Apart f......

Should sublobar resection be offered for screening-detected lung nodules?

期刊: TRANSLATIONAL LUNG CANCER RESEARCH, 2021; 10 (5)

The increasing use of low-dose CT for screening for lung cancer will inevitably identify many small, asymptomatic lung nodules and ground-glass opacit......

Video-assisted thoracoscopic surgery for primary lung cancer resections in patients with moderate to severe chronic obstructive pulmonary diseases

期刊: TRANSLATIONAL LUNG CANCER RESEARCH, 2021; 10 (6)

Background: Lung cancer patients with chronic obstructive pulmonary disease (COPD) are considered a high-risk population to receive radical surgical t......

The multiple roles and therapeutic potential of clusterin in non-small-cell lung cancer: a narrative review

期刊: TRANSLATIONAL LUNG CANCER RESEARCH, 2021; 10 (6)

Worldwide, lung cancer is the most common form of cancer, with an estimated 2.09 million new cases and 1.76 million of death cause in 2018. It is cate......

Risk stratification model for patients with stage I invasive lung adenocarcinoma based on clinical and pathological predictors

期刊: TRANSLATIONAL LUNG CANCER RESEARCH, 2021; 10 (5)

Background: The aim of this study was to propose a new kind of pathological classification and further establish a prognostic model for resected stage......

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