期刊: NATURE METHODS, 2021; 18 (5)
Despite the availability of methods for analyzing protein complexes, systematic analysis of complexes under multiple conditions remains challenging. A......
期刊: NATURE METHODS, 2021; 18 (7)
Universal Spectrum Identifier (USI) provides a standardized mechanism for encoding a virtual path to mass spectra deposited to public repositories or ......
期刊: NATURE METHODS, 2021; 18 (6)
The combination of adaptive optics with an improved isoSTED nanoscope allows imaging of cells and tissues with sub-50-nm isotropic resolution. Underst......
期刊: NATURE METHODS, 2021; 18 (8)
A protein expression atlas of transcription factors charted onto cell lineage maps of Caenorhabditiselegans development that uncovers mechanisms of sp......
期刊: NATURE METHODS, 2021; 18 (6)
Many computational tools for metagenomic profiling have been developed, with different algorithms and features. This analysis shows that, when compari......
期刊: NATURE METHODS, 2021; 18 (8)
Precision mapping of glycans at structural and site-specific level is still one of the most challenging tasks in the glycobiology field. Here, we desc......
期刊: NATURE METHODS, 2021; 18 (7)
Single-lysosome mass spectrometry (SLMS) integrates lysosomal patch-clamp recording and induced nanoESI/MS for concurrent metabolic and electrophysiol......
期刊: NATURE METHODS, 2021; 18 (4)
We introduce an axial localization with repetitive optical selective exposure (ROSE-Z) method for super-resolution imaging. By using an asymmetric opt......
期刊: NATURE METHODS, 2021; 18 (6)
This paper reports CoTECH, which couples chromatin binding enrichment with RNA sequencing for concurrent measurements of histone modification and tran......
期刊: NATURE METHODS, 2021; 18 (6)
Single-cell profiling methods have had a profound impact on the understanding of cellular heterogeneity. While genomes and transcriptomes can be explo......
期刊: NATURE METHODS, 2021; 18 (6)
This work presents NeoLoopFinder, a computational method, for identifying chromatin interactions of structurally rearranged genomes. NeoLoopFinder was......
期刊: NATURE METHODS, 2021; 18 (9)
SnapHiC offers a computational tool for improving detection of chromatin loops from single-cell Hi-C data. Single-cell Hi-C (scHi-C) analysis has been......
期刊: NATURE METHODS, 2021; 18 (6)
We introduce the TRUST4 open-source algorithm for reconstruction of immune receptor repertoires in alpha beta/gamma delta T cells and B cells from RNA......