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Dauricine inhibits human pancreatic carcinoma cell proliferation through regulating miRNAs

期刊: MOLECULAR OMICS, 2021; 17 (4)

Pancreatic cancer is one of the most malignant digestive tract tumors with the worst prognosis. Dauricine (Dau) can inhibit the proliferation of the p......

Identification of epigenetic regulators in the estrogen signaling pathway via siRNA screening

期刊: MOLECULAR OMICS, 2021; 17 (4)

Breast cancer is the most prevalent malignant disease among women across the globe. Notably, estrogen signaling plays a vital role in the progression ......

Identification of core miRNAs and regulatory pathways in breast cancer by integrated bioinformatics analysis

期刊: MOLECULAR OMICS, 2021; 17 (2)

Breast cancer (BC) ranks first among malignancies in the female population due to its complicated pathological progression and poor prognosis. Hence, ......

Genome-scale mutant fitness reveals versatile c-type cytochromes in Shewanella oneidensis MR-1

期刊: MOLECULAR OMICS, 2021; 17 (2)

Shewanella has been widely investigated for its metabolic versatility and use of a large number of extracellular electron acceptors. Many c-type cytoc......

Metabolomics analysis provides new insights into the medicinal value of flavonoids in tobacco leaves

期刊: MOLECULAR OMICS, 2021; 17 (4)

Tobacco is a traditional Chinese medicine containing a variety of biologically active substances. In addition to being used to make cigarettes, tobacc......

The integrated analysis of circRNAs, miRNAs and mRNAs revealed the potential role in the TGF-beta and TNF-alpha signaling pathways of OPLL

期刊: MOLECULAR OMICS, 2021; 17 (4)

Ossification of the posterior longitudinal ligament (OPLL), one of spinal disease causing myelopathy, is characterized by the ectopic ossification and......

Microarray investigation of glycan remodeling during macrophage polarization reveals alpha 2,6 sialic acid as an anti-inflammatory indicator

期刊: MOLECULAR OMICS, 2021; 17 (4)

Glycosylation is a widely occurring posttranslational modification. Here, we applied a quick, convenient and high-throughput strategy (lectin array) t......

Tissue metabolic profiling reveals major metabolic alteration in colorectal cancer

期刊: MOLECULAR OMICS, 2021; 17 (3)

Metabolic reprogramming is a hallmark of cancer, which is still far from being fully understood in colorectal cancer. In order to characterize the met......

Proteome-wide analysis of protein alterations in response to aristolochic acids in rat kidney and liver tissues

期刊: MOLECULAR OMICS, 2021; 17 (3)

Aristolochic acids (AAs), nephrotoxic components of herbs, have been previously demonstrated to cause DNA damage by forming DNA-AA adducts. However, t......

Determination of hypoxia signature to predict prognosis and the tumor immune microenvironment in melanoma

期刊: MOLECULAR OMICS, 2021; 17 (2)

Melanoma is one of the highly malignant skin tumors, the incidence and death of which continue to increase. The hypoxic microenvironment drives tumor ......

Integrated proteomics and phosphoproteomics reveal perturbed regulative pathways in pancreatic ductal adenocarcinoma

期刊: MOLECULAR OMICS, 2021; 17 (2)

Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis largely owing to its inefficient diagnosis, rapid progress, and tenacious drug resistan......

The pan-cancer analysis of the two types of uterine cancer uncovered clinical and prognostic associations with m6A RNA methylation regulators

期刊: MOLECULAR OMICS, ; ()

The role of m6A RNA methylation modification in uterine cancer has not been studied until now. We explored the relationship between m6A regulators and......

NMR-based plasma metabolomics of adult B-cell acute lymphoblastic leukemia

期刊: MOLECULAR OMICS, 2021; 17 (1)

Acute lymphoblastic leukemia (ALL) is one of the common malignant tumors. Compared with childhood ALL, the treatment effect of adult B-cell ALL is les......

Targeted metabolomics reveals dynamic portrayal of amino acids and derivatives in triple-negative breast cancer cells and culture media

期刊: MOLECULAR OMICS, 2021; 17 (1)

Triple-negative breast cancer (TNBC) is well-known for its metastatic aggressiveness and poor survival prognosis, accounting for nearly a quarter of c......

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