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Mendelian randomization analyses for PCOS : evidence, opportunities, and challenges

期刊: TRENDS IN GENETICS, 2022; 38 (5)

Identifying etiological risk factors is significant for preventing and treating patients with polycystic ovary syndrome (PCOS). Through genetic variat......

JIF:8.455

Zebrafish and idiopathic scoliosis: the 'unknown knowns'

期刊: TRENDS IN GENETICS, 2022; 38 (6)

The etiology and heterogeneity of idiopathic scoliosis (IS) are poorly understood. Studies using scoliotic zebrafish models have indicated a potential......

JIF:8.455

Omics studies of DNA G-/C-quadruplexes in plants

期刊: TRENDS IN GENETICS, 2022; 38 (10)

Genome-wide studies of DNA G- and C-quadruplexes (G4s and i-motifs, respectively) can boost the pace of progress towards a comprehensive understanding......

JIF:8.455

Extrachromosomal circular DNA in cancer: history, current knowledge, and methods

期刊: TRENDS IN GENETICS, 2022; 38 (7)

Extrachromosomal circular DNA (eccDNA) is a closed-circle, nuclear, nonplasmid DNA molecule found in all tested eukaryotes. eccDNA plays important rol......

JIF:8.455

Chinese pine (Pinus tabuliformis Carr.)

期刊: TRENDS IN GENETICS, 2022; 38 (4)

Pinus tabuliformis, commonly called Chinese pine, is a drought- and cold-tolerant heliophilous, indigenous conifer species, widespread in China. It ha......

JIF:8.455

From polyploidy to polyploidy reversal: its role in normal and disease states

期刊: TRENDS IN GENETICS, 2022; 38 (10)

Polyploidization and polyploidy reversal (depolyploidization) are crucial pathways to conversely alter genomic contents in organisms. Understanding th......

JIF:8.455

Dissecting super-enhancer heterogeneity: time to re-examine cancer subtypes?

期刊: TRENDS IN GENETICS, 2022; 38 (12)

The heterogeneity of transcriptional regulations by super-enhancers (SEs) is poorly understood in human cancers. Herein, we summarize a bioinformatics......

JIF:8.455

Spotlight Towards precise large genomic fragment deletion

期刊: TRENDS IN GENETICS, 2022; 38 (3)

The prime editing (PE) system can install small insertions and deletions in addition to various base substitutions. Two recent studies published in Na......

JIF:8.455

Why all MODY variants are dominantly inherited: a hypothesis

期刊: TRENDS IN GENETICS, 2022; 38 (4)

Maturity-onset diabetes in the young (MODY) comprises mono genic phenotypes of young-onset, insulinopenic diabetes. All its forms are dominantly inher......

JIF:8.455

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