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Molecular pathways in sepsis-induced cardiomyocyte pyroptosis: Novel finding on long non-coding RNA ZFAS1/miR-138-5p/SESN2 axis

期刊: IMMUNOLOGY LETTERS, 2021; 238 ()

Objective: ZNFX1 antisense RNA1 (ZFAS1) has been emerged as a tumor oncogene or suppressor. However, understanding the biological role and underlying ......

Dynamic role of macrophage CX3CR1 expression in inflammatory bowel disease

期刊: IMMUNOLOGY LETTERS, 2021; 232 ()

Inflammatory bowel disease (IBD), consisting of ulcerative colitis (UC) and Crohn's disease (CD), is featured by overactive immune response and enduri......

The occurrence of lupus nephritis is regulated by USP7-mediated JMJD3 stabilization

期刊: IMMUNOLOGY LETTERS, 2021; 235 ()

Ubiquitin-specific peptidases7 (USP7) participates in the regulation of various metabolic and immune disorders. However, the role of USP7 in lupus nep......

MiR-30a-3p ameliorates oxidative stress in rheumatoid arthritis synovial fibroblasts via activation of Nrf2-ARE signaling pathway

期刊: IMMUNOLOGY LETTERS, 2021; 232 ()

The downregulation of miR-30a-3p has been reported in rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS); however, it is poorly understood its......

Roles of leptin on the key effector cells of rheumatoid arthritis

期刊: IMMUNOLOGY LETTERS, 2021; 233 ()

Leptin, an adipokine sharing structural characteristics of the long-chain helical cytokine family with the crucial role as a regulator in energy homeo......

IL-10 producing B cells regulated 1,3-beta-glucan induced Th responses in coordinated with Treg

期刊: IMMUNOLOGY LETTERS, 2021; 235 ()

Repeated exposure to fungi-contaminated dust can lead to multiple adverse effects on the lung, such as hypersensitivity pneumonitis, granuloma even ir......

Highly activated TRAIL(+) CD56(bright) NK cells are associated with the liver damage in HBV-LC patients

期刊: IMMUNOLOGY LETTERS, 2021; 232 ()

Background: Chronic hepatitis B-related liver cirrhosis(HBV-LC)is the most common cirrhosis in China, which is characterized as liver damage and high ......

GILT in tumor cells improves T cell-mediated anti-tumor immune surveillance

期刊: IMMUNOLOGY LETTERS, 2021; 234 ()

The lysosomal thiol reductase GILT catalyzes the reduction of disulfide bonds of protein antigens, facilitating antigen-presenting cells (APCs) to pre......

The disturbance and clinical significance of B cell and circulating follicular helper T cell subsets in children with primary nephrotic syndrome

期刊: IMMUNOLOGY LETTERS, 2021; 238 ()

The immunopathogenesis of primary nephrotic syndrome is unclear. Here, we examined the frequency, subsets and molecular function of circulating B cell......

Abnormal thymic B cell activation and impaired T cell differentiation in pristane-induced lupus mice

期刊: IMMUNOLOGY LETTERS, 2021; 231 ()

Changes in the thymus and potential mechanisms underlying the pathogenesis in pristane-induced lupus (PIL) mice are poorly understood. This study aime......

CFTR regulates embryonic T lymphopoiesis via Wnt signaling in zebrafish

期刊: IMMUNOLOGY LETTERS, 2021; 234 ()

The number and function of T cells are abnormal as observed in cystic fibrosis (CF) patients and CF mouse models, and our previous work shows that the......

Evaluation of an attenuated Listeria monocytogenes as a vaccine vector to control Helicobacter pylori infection

期刊: IMMUNOLOGY LETTERS, 2021; 238 ()

The increasing resistance of Helicobacter pylori (H. pylori) to antibiotics has limited the efficacy of antibiotic therapy in the treatment of H. pylo......

SARS-CoV-2 Spike protein enhances ACE2 expression via facilitating Interferon effects in bronchial epithelium

期刊: IMMUNOLOGY LETTERS, 2021; 237 ()

Objective: In this study, we focused on the interaction between SARS-CoV-2 and host Type I Interferon (IFN) response, so as to identify whether IFN ef......

The roles of STAT6 in regulating B cell fate, activation, and function

期刊: IMMUNOLOGY LETTERS, 2021; 233 ()

Signal transducers and activators of transcription (STATs) family of proteins are the key signal molecules in the JAK-STAT classical activation pathwa......

Downregulation of DNMT3a expression by RNAi and its effect on NF-kappa Bs expression of thymic epithelial cells

期刊: IMMUNOLOGY LETTERS, 2021; 237 ()

Objective: To understand the characteristics of DNA methyltransferase 3a (DNMT3a) in thymoma associated Myasthenia Gravis reveal its transcriptional r......

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