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Dosage-efficacy relationship and pharmacodynamics validation of brucine dissolving microneedles against rheumatoid arthritis

期刊: JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2021; 63 ()

This study aims to define an optimal dosage and to investigate the therapeutic effects of brucine dissolving microneedles (Bru-DMNs) on rheumatoid art......

Smart GSH/pH dual-bioresponsive degradable nanosponges based on beta-CD-appended hyper-cross-linked polymer for triggered intracellular anticancer drug delivery

期刊: JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2021; 64 ()

Efficient accumulation and on-demand intracellular drug release in the desired site are a crucial issue in developing ideal drug delivery systems (DDS......

Cancer targeted biomimetic drug delivery system

期刊: JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2021; 63 ()

Till now, cancer is one of the most serious diseases causing a high death ratio and a huge challenge to human health. Nanocarriers with the advantages......

In vitro anticancer activity of N-epsilon-acyl lysine methyl ester through folate receptor targeted liposomes

期刊: JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2021; 63 ()

Delivering anticancer drugs to tumor tissues with high specificity to realize minimal adverse effects is currently the main research focus of cancer t......

Improving physicochemical properties of Ibrutinib with cocrystal strategy based on structures and natures of the carboxylic acid co-formers

期刊: JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2021; 63 ()

Ibrutinib(IBR) is an irreversible Bruton's tyrosine kinase inhibitor and has been classified as the Biopharmaceutical Classification System (BCS) clas......

Biosynthesis of silver nanoparticles and the identification of possible reductants for the assessment of in vitro cytotoxic and in vivo antitumor effects

期刊: JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2021; 63 ()

Silver nanoparticles (AgNPs) are well-known for their applications at nano-scale and are potential anticancer agents. Biosynthesis of AgNPs has fashio......

Novel transethosomes for the delivery of brucine and strychnine: Formulation optimization, characterization and in vitro evaluation in hepatoma cells

期刊: JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2021; 64 ()

Nux vomica has been used in China as a traditional medicine for treatment of liver cancer, but its clinical use is limited by serious side-effects. St......

Lipid-polymer nano core-shell type hybrid system for colon specific drug delivery

期刊: JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2021; 63 ()

Site specific drug delivery to the colon provides major advantages to treating diseases associated with the colon, such as inflammatory bowel disease ......

Amphipathic Au-sulfur-poly (ethylene glycol)-b-poly (butylene succinate) system prepared by interfacial reaction as in-silico photosensitizer and antineoplastic carrier

期刊: JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2021; 64 ()

Gold nanoparticles (AuNPs) are widely studied in vitro and in vivo, especially for targeted drug delivery. These drug delivery systems can be engineer......

Preparation of Panax notoginseng flower saponins enteric-coated sustained-release pellets and its pharmacokinetics and in vitro-in vivo correlation

期刊: JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2021; 62 ()

Background: Panax notoginseng flower saponins (PNFS) are great contributions towards the biological activity of Panax notoginseng flower (PNF). Howeve......

A bilayer microneedle for therapeutic peptide delivery towards the treatment of diabetes in db/db mice

期刊: JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2021; 62 ()

Microneedles (MN) provide an alternative approach to hypodermic injection for the delivery of biomacromolecule in a minimally invasive manner. In this......

Engineering micelles for the treatment and diagnosis of atherosclerosis

期刊: JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2021; 63 ()

Atherosclerosis is one of the leading causes of mortality and morbidity worldwide. The consequences of atherosclerotic disease include chronic disease......

Effect of carrier type and Tween (R) 80 concentration on the release of silymarin from amorphous solid dispersions

期刊: JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2021; 63 ()

Silymarin is a mixture of flavonolignans obtained from the seeds of milk thistle (Silybum marianum L. Gaertner). Silymarin behaves as a weak acid and ......

Facile fabrication of nanocarriers with yolk-shell mesoporous silica nanoparticles for effective drug delivery

期刊: JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2021; 63 ()

Drug delivery systems (DDSs) can greatly reduce the negative impact of chemotherapy in the treatment of tumors by alleviating issues such as low solub......

Two branched fructose modification improves tumor targeting delivery of liposomes to breast cancer in intro and in vivo

期刊: JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2021; 61 ()

Breast cancer is the leading cause of cancer death for females and needs more specific treatments. D-fructose is a promising ligand targeting to gluco......

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