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Autophagy inhibition contributes to epigallocatechin-3-gallate-mediated apoptosis in papillary thyroid cancer cells

期刊: MOLECULAR & CELLULAR TOXICOLOGY, 2021; 17 (4)

Background Epigallocatechin-3-gallate is a natural polyphenolic compound that induces apoptosis in papillary thyroid cancer cells. However, its underl......

LncRNA taurine up-regulated gene 1 participates in isoflurane induced neurotoxicity

期刊: MOLECULAR & CELLULAR TOXICOLOGY, 2021; 17 (3)

Background Isoflurane (ISO), with the characteristics of rapid induction and recovery, has become one of the most commonly used inhalation anesthetics......

Kaempferol attenuates spinal cord injury by interfering inflammatory and oxidative stress by targeting the p53 protein: a molecular docking analysis

期刊: MOLECULAR & CELLULAR TOXICOLOGY, 2021; 17 (3)

Background Kaempferol (KMF) is a flavone reported to have anti-oxidant and anti-inflammatory activity. Objective The present study screened the effect......

Pirfenidone ameliorated AGE-induced EMT and attenuated peritoneal fibrosis in peritoneal mesothelial cells

期刊: MOLECULAR & CELLULAR TOXICOLOGY, 2021; 17 (3)

Background Peritoneal dialysis has greatly improved patient survival for patients with chronic kidney disease. However, peritoneal fibrosis is a progr......

Down-regulation of PTTG1 suppresses PDGF-BB-induced proliferation, migration and extracellular matrix production of airway smooth muscle cells (ASMCs) by regulating PI3K/AKT/mTOR signaling pathway

期刊: MOLECULAR & CELLULAR TOXICOLOGY, 2021; 17 (4)

Backgrounds To investigate the biological functions and the molecular mechanisms of PTTG1 in PDGF-BB-induced ASMCs. Objectives QPCR and western blotti......

microRNA-506-3p suppresses the proliferation of triple negative breast cancer cells via targeting SNAI2

期刊: MOLECULAR & CELLULAR TOXICOLOGY, 2021; 17 (4)

Background The lacking of estrogen, progesterone and ERBB2 receptor makes the therapy of Triple negative breast cancer (TNBC) is particularly challeng......

Curcumin suppresses oxidative stress via regulation of ROS/NF-kappa B signaling pathway to protect retinal vascular endothelial cell in diabetic retinopathy

期刊: MOLECULAR & CELLULAR TOXICOLOGY, 2021; 17 (3)

Background The retinal vascular endothelial cells can be damaged by oxidative stress even in the early stage of diabetic retinopathy (DR). This study ......

Sevoflurane induces neuronal apoptosis via enhancing DNMT3L expression and promoting methylation of PSD95 promoter in postoperative cognitive dysfunction

期刊: MOLECULAR & CELLULAR TOXICOLOGY, 2021; 17 (3)

Background Postoperative cognitive dysfunction (POCD) is a central nervous system (CNS) complication and occurs quite frequently after anesthesia, esp......

Dapk1 promoted inflammation of infantile pneumonia by p38MAPK/NF-kappa B signaling pathway

期刊: MOLECULAR & CELLULAR TOXICOLOGY, 2021; 17 (3)

Background The present study was designed to investigate the function of death-associated protein kinase 1 (DAPK1) in infantile pneumonia and explore ......

Naringenin alleviates bone cancer pain in rats via down-regulating spinal P2X7R/PI3K/AKT signaling: involving suppression in spinal inflammation

期刊: MOLECULAR & CELLULAR TOXICOLOGY, 2021; 17 (4)

Background Bone cancer pain (BCP) seriously affects patient's quality of life, which remains a difficult clinical problem, lacking effective drugs for......

USP38 protein alleviates neuroinflammation of cerebral ischemia-reperfusion injury via KDM5B expression

期刊: MOLECULAR & CELLULAR TOXICOLOGY, 2021; 17 (4)

Background Cerebrovascular disease is a common chronic disease in the middle-aged and elderly population, with severe damage. Timely restoration of is......

USP18 promotes the growth in hemangiomas by regulating PI3K/AKT pathway

期刊: MOLECULAR & CELLULAR TOXICOLOGY, 2021; 17 (4)

Background USP (ubiquitin-specific peptidase) 18 functions as deubiquitinating enzyme and participates in various human malignancies. The underlying m......

Liver kinase B1 (LKB1) reduced inflammation and oxidative stress by regulating the AMPK/NLRP3 signaling pathway in LPS-induced lung injury

期刊: MOLECULAR & CELLULAR TOXICOLOGY, 2021; 17 (4)

Background Inflammation and oxidative stress-induced molecular death are one of the important causes for lung injury in critically ill patients. LKB1 ......

Anti-proliferation and pro-apoptosis effects of miR-582-5p in chronic lymphocytic leukemia via targeting HNRNPA1 and suppression of NF-kappa B

期刊: MOLECULAR & CELLULAR TOXICOLOGY, 2021; 17 (3)

Background MicroRNAs (miRNAs) function as post-transcriptional mediators for genes involved in cancer progression, including chronic lymphocytic leuke......

Allylpyrocatechol ameliorates sepsis-induced lung injury via SIRT1-mediated suppression of p65 and nucleocytoplasmic translocation of HMGB1

期刊: MOLECULAR & CELLULAR TOXICOLOGY, 2021; 17 (4)

Background Sepsis is a deadly clinical condition. Allylpyrocatechol is bioactive flavonoid that has shown promising anti-inflammatory and antioxidant ......

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