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Application of Machine Learning Techniques in Drug-target Interactions Prediction

期刊: CURRENT PHARMACEUTICAL DESIGN, 2021; 27 (17)

Background: Drug-Target interactions are vital for drug design and drug repositioning. However, traditional lab experiments are both expensive and tim......

3-MA Enhanced Chemosensitivity in Cisplatin Resistant Hypopharyngeal Squamous Carcinoma Cells via Inhibiting Beclin-1 Mediated Autophagy

期刊: CURRENT PHARMACEUTICAL DESIGN, 2021; 27 (7)

Background: Hypopharyngeal carcinoma is characterized by a high degree of malignancy. The most common pathological type is squamous cell carcinoma (HS......

Expression of Rab3b in Human Glioma: Influence on Cell Proliferation and Apoptosis

期刊: CURRENT PHARMACEUTICAL DESIGN, 2021; 27 (7)

Background: Glioma is the most common human central nervous system tumour with a high degree of malignancy. Some Rab GTPases have significant effects ......

The Next Generation of Machine Learning in DDIs Prediction

期刊: CURRENT PHARMACEUTICAL DESIGN, 2021; 27 (23)

Drug-drug interactions may occur when combining two or more drugs may cause some adverse events such as cardiotoxicity, central neurotoxicity, hepatot......

miRNAs in SARS-CoV 2: A Spoke in the Wheel of Pathogenesis

期刊: CURRENT PHARMACEUTICAL DESIGN, 2021; 27 (13)

Introduction: The rapid emergence of Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) has resulted in an increased mortality rate across t......

Comprehensive DNA Methylation-transcriptome Profiles Association Analysis During the Treatment of Acute Myelocytic Leukemia

期刊: CURRENT PHARMACEUTICAL DESIGN, 2021; 27 (24)

Background: Epigenetic modifications have recently attracted much attention in the study of the biological mechanisms of Acute Myelocytic Leukemia (AM......

Traditional Chinese Medicine Network Pharmacology in Cardiovascular Precision Medicine

期刊: CURRENT PHARMACEUTICAL DESIGN, 2021; 27 (26)

Cardiovascular disease is a major disease affecting human health, and its pathogenesis is caused by many factors. Through the use of "omics" technolog......

Recent Advances in Pharmacological Interventions of Chronic Prostatitis/ Chronic Pelvic Pain Syndrome

期刊: CURRENT PHARMACEUTICAL DESIGN, 2021; 27 (25)

Chronic prostatitis/chronic pelvic pain syndrome type III is related to irritative voiding, sexual dysfunction, and pelvic pain. Chronic prostatitis/c......

Strategies for Preparing Different Types of Lipid Polymer Hybrid Nanoparticles in Targeted Tumor Therapy

期刊: CURRENT PHARMACEUTICAL DESIGN, 2021; 27 (19)

At present, cancer is one of the most common diseases in the world, causing a large number of deaths and seriously affecting people's health. The trad......

Neuroprotective and Preventative Effects of Molecular Hydrogen

期刊: CURRENT PHARMACEUTICAL DESIGN, 2021; 27 (5)

One of the beneficial effects of molecular hydrogen (H-2, hydrogen gas) is neuroprotection and prevention of neurological disorders. It is important a......

Recognition of Ion Ligand Binding Sites Based on Amino Acid Features with the Fusion of Energy, Physicochemical and Structural Features

期刊: CURRENT PHARMACEUTICAL DESIGN, 2021; 27 (8)

Background: Rational drug molecular design based on virtual screening requires the ligand binding site to be known. Recently, the recognition of ion l......

Microglia NLRP3 Inflammasomes Activation Involving Diabetic Neuroinflam-mation in Diabetic Mice and BV2 Cells

期刊: CURRENT PHARMACEUTICAL DESIGN, 2021; 27 (24)

Background: Hyperglycemia-induced microglia activation can cause a continuous release of proinflammatory cytokines, which gradually damages neurons an......

The Effect of Metformin on Aminotransferase Levels, Metabolic Parameters and Body Mass Index in Nonalcoholic Fatty Liver Disease Patients: A Meta-analysis

期刊: CURRENT PHARMACEUTICAL DESIGN, 2021; 27 (29)

Background: Nonalcoholic fatty liver disease (NAFLD) is one of the most common reasons for the increase in serum alanine aminotransferase (ALT) and as......

Hydrogen Commonly Applicable from Medicine to Agriculture: From Molecular Mechanisms to the Field

期刊: CURRENT PHARMACEUTICAL DESIGN, 2021; 27 (5)

The emerging field of hydrogen biology has to date mainly been applied in medicine. However, hydrogen biology can also enable positive outcomes in agr......

New Strategies from Natural Materials to Fight against Diet- induced Metabolic Disorders (Part-II)

期刊: CURRENT PHARMACEUTICAL DESIGN, 2021; 27 (6)

According to the global statistics, the incidence of metabolic syndrome (MetS), which is a multifactorial disease with multiple risk factors, has reac......

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