期刊： NATURE REVIEWS RHEUMATOLOGY, 2021; 17 (9)
Osteoarthritis (OA) is a whole-joint disease characterized by subchondral bone perfusion abnormalities and neovascular invasion into the synovium and ......
期刊： NATURE REVIEWS RHEUMATOLOGY, 2020; 16 (8)
Osteoarthritis (OA) is a complex musculoskeletal disease and a leading cause of pain and disability worldwide. Hip and knee OA alone are major contrib......
期刊： NATURE REVIEWS RHEUMATOLOGY, 2020; 16 (9)
Methylation of cytosine residues in DNA, the best studied epigenetic modification, is associated with gene transcription and nuclear organization, and......
期刊： NATURE REVIEWS RHEUMATOLOGY, 2020; 16 (10)
Regulated fibroblast growth factor (FGF) signalling is a prerequisite for the correct development and homeostasis of articular cartilage, as evidenced......
期刊： NATURE REVIEWS RHEUMATOLOGY, 2022; 18 (12)
Systemic sclerosis (SSc) is a destructive connective tissue disease characterized by dysregulation of the immune system and fibrosis in the skin and i......
期刊： NATURE REVIEWS RHEUMATOLOGY, 2019; 15 (1)
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by a failure of spontaneous resolution of inflammation. Although the pro-infla......
期刊： NATURE REVIEWS RHEUMATOLOGY, 2019; 15 (2)
Intervertebral disc (IVD) degeneration is associated with low back pain. In IVDs, a high mechanical load, high osmotic pressure and hypoxic conditions......
期刊： NATURE REVIEWS RHEUMATOLOGY, 2019; 15 (7)
Hyperuricaemia (increased serum urate concentration) occurs mainly in higher primates, including in humans, because of inactivation of the gene encodi......
期刊： NATURE REVIEWS RHEUMATOLOGY, 2019; 15 (8)
As a hallmark of autoimmune rheumatic diseases, autoantibodies have been used in diagnosis for decades. However, the immunological mechanism underlyin......
期刊： NATURE REVIEWS RHEUMATOLOGY, 2019; 15 (10)
Rheumatoid arthritis (RA) is a chronic autoimmune disorder that causes joint inflammation and damage. Extra-articular manifestations occur in many pat......
期刊： NATURE REVIEWS RHEUMATOLOGY, 2017; 13 (1)
The transition of HIV and AIDS from a death sentence to a chronic disease has not come without problems. Rheumatologists need to be aware of the full ......
