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Determinants of primate neurogenesis and the deployment of top-down generative networks in the cortical hierarchy

期刊: CURRENT OPINION IN NEUROBIOLOGY, 2021; 66 ()

Because primate cortical development exhibits numerous specific features, the mouse is an imperfect model for human cortical development. Expansion of......

Modeling brain development and diseases with human cerebral organoids

期刊: CURRENT OPINION IN NEUROBIOLOGY, 2021; 66 ()

Understanding the mechanisms that underlie human brain development and neurological and neuropsychiatric disorders is one of the key topics of neurobi......

Behavior and lineage progression of neural progenitors in the mammalian cortex

期刊: CURRENT OPINION IN NEUROBIOLOGY, 2021; 66 ()

The cerebral cortex is a central structure in the mammalian brain that enables higher cognitive functions and intellectual skills. It is the hallmark ......

Centrosome regulation and function in mammalian cortical neurogenesis Jiajun Yang, Xiaoqing Hu, Jian Ma and Song-Hai Shi

期刊: CURRENT OPINION IN NEUROBIOLOGY, 2021; 69 ()

As the primary microtubule-organizing center in animal cells, centrosomes regulate microtubule cytoskeleton to support various cellular behaviors. The......

APOE signaling in neurodegenerative diseases: an integrative approach targeting APOE coding and noncoding variants for disease intervention

期刊: CURRENT OPINION IN NEUROBIOLOGY, 2021; 69 ()

APOE (apolipoprotein E) is a key regulator of lipid metabolism and a leading genetic risk factor for Alzheimer's disease. While APOE participates in m......

Brain-wide, scale-wide physiology underlying behavioral flexibility in zebrafish

期刊: CURRENT OPINION IN NEUROBIOLOGY, 2020; 64 ()

The brain is tasked with choosing actions that maximize an animal's chances of survival and reproduction. These choices must be flexible and informed ......

Brain connectomes come of age

期刊: CURRENT OPINION IN NEUROBIOLOGY, 2020; 65 ()

Databases of consistent, directed- and weighted inter-areal connectivity for mouse, macaque and marmoset monkeys have recently become available and be......

Phase separation as a mechanism for assembling dynamic postsynaptic density signalling complexes

期刊: CURRENT OPINION IN NEUROBIOLOGY, 2019; 57 ()

The postsynaptic density (PSD) is an electron dense, semi membrane bound compartment that lies beneath postsynaptic membranes. This region is densely ......

JIF:6.01

Lateral habenula in the pathophysiology of depression

期刊: CURRENT OPINION IN NEUROBIOLOGY, 2018; 48 ()

Depression is a devastating disorder with a combination of diverse symptoms such as low self-esteem, lack of motivation, anhedonia, loss of appetite, ......

JIF:6.01

Deciphering MECP2-associated disorders: disrupted circuits and the hope for repair

期刊: CURRENT OPINION IN NEUROBIOLOGY, 2018; 48 ()

MECP2 is a critical gene for neural development, mutations or duplication of which led to severe neurodevelopmental disorders, such as Rett syndrome (......

JIF:6.01

Advances in understanding neural mechanisms of social dominance

期刊: CURRENT OPINION IN NEUROBIOLOGY, 2018; 49 ()

Dominance hierarchy profoundly impacts social animals' survival, physical and mental health and reproductive success. As the measurements of dominance......

JIF:6.01

Lighting up the brain: genetically encoded fluorescent sensors for imaging neurotransmitters and neuromodulators

期刊: CURRENT OPINION IN NEUROBIOLOGY, 2018; 50 ()

Measuring the precise dynamics of specific neurotransmitters and neuromodulators in the brain is essential for understanding how information is transm......

JIF:6.01

Vestibular signals in primate cortex for self-motion perception

期刊: CURRENT OPINION IN NEUROBIOLOGY, 2018; 52 ()

The vestibular peripheral organs in our inner ears detect transient motion of the head in everyday life. This information is sent to the central nervo......

JIF:6.01

Building stereotypic connectivity: mechanistic insights into structural plasticity from C. elegans

期刊: CURRENT OPINION IN NEUROBIOLOGY, 2018; 48 ()

The ability of neurons to modify or remodel their synaptic connectivity is critical for the function of neural circuitry throughout the life of an ani......

JIF:6.01

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