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Arecoline Hydrobromide Enhances Jejunum Smooth Muscle Contractility via Voltage-Dependent Potassium Channels in W/W-v Mice

期刊: PHYSIOLOGICAL RESEARCH, 2021; 70 (3)

Gastrointestinal motility was disturbed in W/W-v, which were lacking of interstitial cells of Cajal (ICC). In this study, we have investigated the rol......

Electroacupuncture Inhibits the Interaction between Peripheral TRPV1 and P2X3 in Rats with Different Pathological Pain

期刊: PHYSIOLOGICAL RESEARCH, 2021; 70 (4)

Chronic pain is regarded to be one of the common and refractory diseases to cure in the clinic. One hundred Hz electroacupuncture (EA) is commonly use......

Effects of Concentrated Growth Factor and Nanofat on Aging Skin of Nude Mice Induced by D-Galactose

期刊: PHYSIOLOGICAL RESEARCH, 2021; 70 (3)

This investigation studied the effect of concentrated growth factor and nanofat on aging skin of nude mice induced by D-galactose. BALB/c mice were ra......

Phenotype and Function of Macrophage Polarization in Monocrotaline-Induced Pulmonary Arterial Hypertension Rat Model

期刊: PHYSIOLOGICAL RESEARCH, 2021; 70 (2)

Pulmonary arterial hypertension (PAH) is a fatal disease characterized by vascular remodeling and chronic inflammation. Macrophages are the key orches......

Application of Modified Mesenchymal Stem Cells Transplantation in the Treatment of Liver Injury

期刊: PHYSIOLOGICAL RESEARCH, 2021; 70 (3)

Acute and chronic hepatitis, cirrhosis, and other liver diseases pose a serious threat to human health; however, liver transplantation is the only rel......

Downregulation of Long Non-Coding RNA AIRN Promotes Mitophagy in Alcoholic Fatty Hepatocytes by Promoting Ubiquitination of mTOR

期刊: PHYSIOLOGICAL RESEARCH, 2021; 70 (2)

Long non-coding RNAs (lncRNAs) are crucial in chronic liver diseases, but the specific molecular mechanism of lncRNAs in alcoholic fatty liver (AFL) r......

Valsartan Prevented Neointimal Hyperplasia and Inhibited SRSF1 Expression and the TLR4-iNOS-ERK-AT1 Receptor Pathway in the Balloon-injured Rat Aorta

期刊: PHYSIOLOGICAL RESEARCH, 2021; 70 (4)

Valsartan has the potential to attenuate neointimal hyperplasia and to suppress the inflammatory response. This study aimed to evaluate the role of va......

Plasma Asprosin, CCDC80 and ANGPTL4 Levels Are Associated With Metabolic and Cardiovascular Risk in Patients With Inflammatory Bowel Disease

期刊: PHYSIOLOGICAL RESEARCH, 2021; 70 (2)

Asprosin, coiled-coil domain-containing 80(CCDC80) and angiopoietin-like 4(ANGPTL4) are newly discovered adipocytokine that affects glucose tolerance,......

MiR-133a-3p Relieves the Oxidative Stress Induced Trophoblast Cell Apoptosis Through the BACH1/Nrf2/HO-1 Signaling Pathway

期刊: PHYSIOLOGICAL RESEARCH, 2021; 70 (1)

Preeclampsia (PE) is a major cause of the pregnancy morbidity and mortality over the world. Disorganized placentation caused by trophoblast cell abnor......

Eicosapentaenoic Acid Enhances Skeletal Muscle Hypertrophy Without Altering the Protein Anabolic Signaling Pathway

期刊: PHYSIOLOGICAL RESEARCH, 2021; 70 (1)

This study aimed to examine the effect of eicosapentaenoic acid (EPA) on skeletal muscle hypertrophy induced by muscle overload and the associated int......

The Critical Role of Hippocampal Dopamine in the Pathogenesis of Hepatic Encephalopathy

期刊: PHYSIOLOGICAL RESEARCH, 2021; 70 (1)

The pathogenesis of hepatic encephalopathy (HE) has been generally linked to blood ammonia, gamma-aminobutyric acid and serotonin. However, the exact ......

Comparison of Pancreatic Microcirculation Profiles in Spontaneously Hypertensive Rats and Wistar-Kyoto Rats by Laser Doppler and Wavelet Transform Analysis

期刊: PHYSIOLOGICAL RESEARCH, 2020; 69 (6)

Pancreatic microcirculatory dysfunction emerged as a novel mechanism in the development of hypertension. However, the changes of pancreatic microcircu......

The Involvement of Protein Kinases in the Cardioprotective Effect of Chronic Hypoxia

期刊: PHYSIOLOGICAL RESEARCH, 2020; 69 (6)

The purpose of this review is to analyze the involvement of protein kinases in the cardioprotective mechanism induced by chronic hypoxia. It has been ......

Inhibition of NADPH oxidase within midbrain periaqueductal gray decreases pain sensitivity in Parkinson's disease via GABAergic signaling pathway

期刊: PHYSIOLOGICAL RESEARCH, 2020; 69 (4)

Hypersensitive pain response is observed in patients with Parkinson's disease (PD). However, the signal pathways leading to hyperalgesia still need to......

Wnt/beta-Catenin Signaling Contributes to Vincristine-Induced Neuropathic Pain

期刊: PHYSIOLOGICAL RESEARCH, 2020; 69 (4)

Chemotherapy-induced neuropathic pain (CNP) is the major dose-limiting factor in cancer chemotherapy. However, the mechanisms underlying CNP remain el......

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