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Systematic evaluation of sample preparation strategy for GC-MS-based plasma metabolomics and its application in osteoarthritis

期刊: ANALYTICAL BIOCHEMISTRY, 2021; 621 ()

Sample preparation plays a crucial part in plasma metabolomics. In order to obtain an optimal sample extraction method for gas chromatography mass spe......

In situ continuously monitoring of cancer cell invasion process based on impedance sensing

期刊: ANALYTICAL BIOCHEMISTRY, 2021; 622 ()

Activation of invasion and metastasis is recognized as one of the hallmarks of cancer. There are 90% of cancerrelated deaths due to metastasis and giv......

Simultaneous separation and determination of three huperzine alkaloids in Huperzia serrata and its preparations by cyclodextrin-modified mixed micellar electrokinetic capillary chromatography

期刊: ANALYTICAL BIOCHEMISTRY, 2021; 623 ()

In this study, a simple and sensitive cyclodextrin-modified mixed micellar electrokinetic capillary chromatography (CD-MEKC) method has been developed......

Development of a fluorescence-based assay for screening of urate transporter 1 inhibitors using 6-carboxyfluorescein

期刊: ANALYTICAL BIOCHEMISTRY, 2021; 626 ()

The urate transporter 1 (URAT1) inhibitors were considered a very promising class of uricosuric agents for the treatment of hyperuricemia and gout. In......

Disruptors, a new class of oligonucleotide reagents, significantly improved PCR performance on templates containing stable intramolecular secondary structures

期刊: ANALYTICAL BIOCHEMISTRY, 2021; 624 ()

Intramolecular secondary structures within templates have been shown to lower PCR performance. Whereas many approaches have been developed to mitigate......

Streamlined purification and characterization of Pyrococcus furiosus rubredoxins with different N-terminal modifications by reversed-phase HPLC

期刊: ANALYTICAL BIOCHEMISTRY, 2021; 619 ()

Rubredoxins (Rds), like those from Pyrococcus furious (Pf), have largely been found to be expressed in Escherichia coli (E. coli) as a mixture of diff......

Characterization and monitoring of charge variants of a recombinant monoclonal antibody using microfluidic capillary electrophoresis-mass spectrometry

期刊: ANALYTICAL BIOCHEMISTRY, 2021; 625 ()

Rigorous characterization of biotherapeutics, and monoclonal antibodies in particular, is a challenging task in terms of ensuring safety, efficacy, an......

Serum metabonomic study of the effects of Huofeitong tablet on rats with COPD

期刊: ANALYTICAL BIOCHEMISTRY, 2021; 620 ()

Chronic obstructive pulmonary disease (COPD) is a common respiratory disease. The Huofeitong tablet (HFTT), a Chinese compound medicine, exhibits an u......

An integrative method based on UHPLC-Q-TOF-MS/MS combined with metabolomics to authenticate Isodon rubescens

期刊: ANALYTICAL BIOCHEMISTRY, 2021; 629 ()

Genuine regional drugs have played a vital role in clinical use for a long time. There are differences in traditional Chinese medicines (TCM) from dif......

Ultrasensitive and selective fluorescent sensor for cysteine and application to drug analysis and bioimaging

期刊: ANALYTICAL BIOCHEMISTRY, 2021; 620 ()

A fluorescent sensor based on coumarin-maleimide conjugate was developed for efficient discrimination of Cys from Hcy and GSH in both organic and aque......

Detection of Epstein-Barr virus encoded RNA in fixed cells and tissues using CRISPR/Cas-mediated RCasFISH

期刊: ANALYTICAL BIOCHEMISTRY, 2021; 625 ()

Identification of Epstein-Barr virus (EBV)-infected cells is critical for the diagnosis and clinical management of EBV-associated diseases. EBV-encode......

Establishment of inhibitor screening and validation system for tryptophanyl tRNA synthetase using surface plasmon resonance

期刊: ANALYTICAL BIOCHEMISTRY, 2021; 623 ()

With the increase in throughput and sensitivity, biophysical technology has become a major component of the early drug discovery phase. Surface plasmo......

Evaluating the interplay among stationary phases/ion-pairing reagents/ sequences for liquid chromatography mass spectrometry analysis of oligonucleotides

期刊: ANALYTICAL BIOCHEMISTRY, 2021; 625 ()

The correlation among stationary phases, ion-pairing reagents (IPR) and sequences for ion-pair reversed-phase liquid chromatography mass spectrometry ......

Effect of sample volume on the sensitivity of lateral flow assays through computational modeling

期刊: ANALYTICAL BIOCHEMISTRY, 2021; 619 ()

Lateral flow assays (LFAs) are extensively used in qualitative detection because of their convenience, low cost, fast results, and ease of operation. ......

RPA-SYBR Green I based instrument-free visual detection for pathogenic Yersinia enterocolitica in meat

期刊: ANALYTICAL BIOCHEMISTRY, 2021; 621 ()

Pathogenic Yersinia (Y.) enterocolitica is the primary causative agent of Yersiniosis, with outbreaks in numerous countries around the world, and caus......

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