期刊： GENES CHROMOSOMES & CANCER, 2022; 61 (4)
We report an aggressive soft tissue sarcoma with FGFR1-TACC1 fusion occurring in the thigh of an 83-year-old man. Microscopically, the tumor was compo......
期刊： GENES CHROMOSOMES & CANCER, 2022; 61 (4)
Anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC) respond well to ALK tyrosine kinase inhibitors (TKIs), and echinoderm m......
期刊： GENES CHROMOSOMES & CANCER, 2022; 61 (9)
The incidence of primary and acquired BRAF mutations is low in non-small cell lung cancer (NSCLC), with limited demographic and treatment outcome data......
期刊： GENES CHROMOSOMES & CANCER, 2022; 61 (1)
Most tumors are sporadic and originated from somatic mutations. Some rare germline mutations cause familial tumors, often involving multiple tissues o......
期刊： GENES CHROMOSOMES & CANCER, 2021; 60 (11)
Malignant peripheral nerve sheath tumors (MPNSTs) are a type of sarcoma that generally originates from Schwann cells. The prognosis for this type of m......
期刊： GENES CHROMOSOMES & CANCER, 2020; 59 (10)
Recently, a novel group of spindle cell tumors defined by S100 and CD34 co-expression harboring recurrent fusions involvingRET,RAF1,BRAF, andNTRK1/2ge......
期刊： GENES CHROMOSOMES & CANCER, 2020; 59 (8)
Aggressive morphologic variants of mantle cell lymphoma (MCL), including blastoid and pleomorphic (B/P-MCL), are rare and associated with poor clinica......
期刊： GENES CHROMOSOMES & CANCER, 2020; 59 (7)
Chromosomal translocations and generating fusion genes are closely associated with disease initiation and progression in acute myeloid leukemia (AML).......
期刊： GENES CHROMOSOMES & CANCER, 2019; 58 (1)
TP53 disruption is considered to be the most important prognostic factor in chronic lymphocytic leukemia (CLL), but not all patients with TP53 disrupt......
期刊： GENES CHROMOSOMES & CANCER, 2020; 59 (1)
Genetic interaction has been recognized to be an important cause of the missing heritability. The topologically associating domain (TAD) is a self-int......
期刊： GENES CHROMOSOMES & CANCER, 2020; 59 (2)
Hypoxia-induced epithelial-mesenchymal transition (EMT) involves the interplay between chromatin modifiers histone deacetylase 3 (HDAC3) and WDR5. The......
期刊： GENES CHROMOSOMES & CANCER, 2019; 58 (10)
Fibroblastic/myofibroblastic neoplasms represent a broad, and occasionally diagnostically challenging, category of soft tissue neoplasms. A subset of ......
期刊： GENES CHROMOSOMES & CANCER, 0; ()
Both EWSR1 and TFE3 are well-known oncogenes. EWSR1 encodes an RNA-binding protein involved in multiple soft tissue tumors, including Ewing's sarcoma/......
期刊： GENES CHROMOSOMES & CANCER, 2018; 57 (4)
Molecular analysis of potentially actionable mutations has become routine practice in oncological pathology. However, testing a wide range of oncogene......
