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Rediscovering Tocophersolan: A Renaissance for Nano-Based Drug Delivery and Nanotheranostic Applications

期刊: CURRENT DRUG TARGETS, 2021; 22 (8)

A unique and pleiotropic polymer, d-alpha-tocopheryl polyethylene glycol succinate (Tocophersolan), is a polymeric, synthetic version of vitamin E. To......

Biomimetic Drug Delivery Systems Oriented by Biological Function in Tumor Targeting

期刊: CURRENT DRUG TARGETS, 2021; 22 (8)

The emergence of nanoscale drug delivery systems provides new opportunities for targeting the delivery of chemotherapeutic drugs and has achieved exce......

Endogenous Enzyme-responsive Nanoplatforms for Anti-tumor Therapy

期刊: CURRENT DRUG TARGETS, 2021; 22 (8)

The emergency of responsive drug delivery systems has contributed to reduced cyto-toxicity, improved permeability in tissues and extended circulation ......

The Fate of Nanoparticles In Vivo and the Strategy of Designing Stealth Nanoparticle for Drug Delivery

期刊: CURRENT DRUG TARGETS, 2021; 22 (8)

Nano-drug delivery systems (Nano-DDS) offer powerful advantages in drug delivery and targeted therapy for diseases. Compared to the traditional drug f......

Review of the Biological Activity of Maslinic Acid

期刊: CURRENT DRUG TARGETS, 2021; 22 (13)

Since the discovery of (2 alpha,3 beta)-2,3-dihydroxyolean-12-en-28-oic acid, also known as maslinic acid, many studies have examined its biological a......

Self-Assembled Micelles of Amphiphilic PEGylated Drugs for Cancer Treatment

期刊: CURRENT DRUG TARGETS, 2021; 22 (8)

Generally, poor solubility and imprecise delivery of chemotherapeutic drugs can compromise their efficacies for clinical cancer treatment. In order to......

P2X7 Receptor as a Potential Target for Major Depressive Disorder

期刊: CURRENT DRUG TARGETS, 2021; 22 (10)

Major depressive disorder (MDD) is a common mental disorder. Although the genetic, biochemical, and psychological factors have been related to the dev......

Application and Future Prospect of Extracellular Matrix Targeted Nano-materials in Tumor Theranostics

期刊: CURRENT DRUG TARGETS, 2021; 22 (8)

Systemic chemotherapy and radiotherapy have been widely used in clinics for several decades, but their disadvantages, such as systemic cytotoxicity an......

The Regulatory Role of Rho GTPases and their Substrates in Osteoclasto-genesis

期刊: CURRENT DRUG TARGETS, 2021; 22 (9)

Pathological bone loss diseases (osteolysis, Paget's diseases) are commonly caused by the excessive differentiation and activity of osteoclasts. The R......

Cell-penetrating Peptide-mediated Nanovaccine Delivery

期刊: CURRENT DRUG TARGETS, 2021; 22 (8)

Vaccination with small antigens, such as proteins, peptides, or nucleic acids, is used to activate the immune system and trigger the protective immune......

The Gut Microbiota and Traditional Chinese Medicine: A New Clinical Frontier on Cancer

期刊: CURRENT DRUG TARGETS, 2021; 22 (11)

Gut microbiota is a complex microecosystem, which is called the second genome of the human body. Herbal medicine can balance tumor-suppressing bacteri......

Progress on the Mechanism for Aspirin's Anti-tumor Effects

期刊: CURRENT DRUG TARGETS, 2021; 22 (1)

Since its discovery more than 100 years ago, aspirin has been widely used for its antipyretic, analgesic, anti-inflammatory, and anti-rheumatic activi......

Pivotal Role of the Interaction Between Herbal Medicines and Gut Microbiota on Disease Treatment

期刊: CURRENT DRUG TARGETS, 2021; 22 (3)

With the recognition of the important role of gut microbiota in both health and disease progression, attempts to modulate its composition, as well as ......

The Potential Therapeutic Role of the HMGB1-TLR Pathway in Epilepsy

期刊: CURRENT DRUG TARGETS, 2021; 22 (2)

Epilepsy is one of the most common serious neurological disorders, affecting over 70 million people worldwide. For the treatment of epilepsy, antiepil......

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