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Development and Validation of a Diagnostic Nomogram to Predict the Anthracycline-Induced Early Cardiotoxicity in Children with Hematological Tumors

期刊: CARDIOVASCULAR TOXICOLOGY, 2022; 22 (9)

This study aimed to establish and validate an effective nomogram to predict the risk of cardiotoxicity in children after each anthracycline treatment.......

JIF:2.795

PM2.5-Induced Programmed Myocardial Cell Death via mPTP Opening Results in Deteriorated Cardiac Function in HFpEF Mice

期刊: CARDIOVASCULAR TOXICOLOGY, 2022; 22 (8)

PM2.5 exposure can induce or exacerbate heart failure and is associated with an increased risk of heart failure hospitalization and mortality; however......

JIF:2.795

Mesenchymal Stem Cell-Derived Exosome-Loaded microRNA-129-5p Inhibits TRAF3 Expression to Alleviate Apoptosis and Oxidative Stress in Heart Failure

期刊: CARDIOVASCULAR TOXICOLOGY, 2022; 22 (7)

Heart failure (HF) represents a main global healthy and economic burden with unacceptably high morbidity and mortality rates. In the current study, we......

JIF:2.795

AAV9-Mediated Cardiac CNTF Overexpression Exacerbated Adverse Cardiac Remodeling in Streptozotocin-Induced Type 1 Diabetic Models

期刊: CARDIOVASCULAR TOXICOLOGY, 2022; 22 (1)

Ciliary neurotrophic factor (CNTF), which is a neural peptide, has been reported to confer cardioprotective effects. However, whether CNTF-based gene ......

JIF:2.795

Cardiac Expression of Esophageal Cancer-Related Gene-4 is Regulated by Sp1 and is a Potential Early Target of Doxorubicin-Induced Cardiotoxicity

期刊: CARDIOVASCULAR TOXICOLOGY, 2022; 22 (5)

Esophageal Cancer-Related Gene 4 (Ecrg4) expressed in cardiomyocytes and the cardiac conduction system is downregulated during cardiac ischemia and at......

JIF:2.795

AT1 Receptors: Their Actions from Hypertension to Cognitive Impairment

期刊: CARDIOVASCULAR TOXICOLOGY, 2022; 22 (4)

Hypertension is one of the most prevalent cardiovascular disorders worldwide, affecting 1.13 billion people, or 14% of the global population. Hyperten......

JIF:2.795

PD-1 Inhibitor-Induced Thyrotoxicosis Associated with Coronary Artery Spasm and Ventricular Tachycardia

期刊: CARDIOVASCULAR TOXICOLOGY, 2022; 22 (10-11)

Programmed cell death protein 1 (PD-1) inhibitors open a new era of cancer immunotherapy, but they are associated with immune-related adverse events (......

JIF:2.795

Yohimbine Directly Induces Cardiotoxicity on Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes

期刊: CARDIOVASCULAR TOXICOLOGY, 2022; 22 (2)

Yohimbine is a highly selective and potent alpha(2)-adrenoceptor antagonist, which is usually treated as an adjunction for impotence, as well for weig......

JIF:2.795

Metoprolol Protects Against Arginine Vasopressin-Induced Cellular Senescence in H9C2 Cardiomyocytes by Regulating the Sirt1/p53/p21 Axis

期刊: CARDIOVASCULAR TOXICOLOGY, 2022; 22 (2)

Cardiomyocyte senescence is involved in the pathological mechanism of cardiac diseases. Metoprolol is a beta 1 receptor blocker used for the treatment......

JIF:2.795

LncRNA MALAT1 Regulates USP22 Expression Through EZH2-Mediated H3K27me3 Modification to Accentuate Sepsis-Induced Myocardial Dysfunction

期刊: CARDIOVASCULAR TOXICOLOGY, 2022; 22 (9)

Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a long non-coding RNA (lncRNA), has been confirmed to recruit enhancer of zeste 2 pol......

JIF:2.795

An Improved Monkey Model of Myocardial Ischemic Infarction for Cardiovascular Drug Development

期刊: CARDIOVASCULAR TOXICOLOGY, 2022; 22 (9)

Non-human primate monkey model of myocardial ischemic infarction is precious for translational medicine research. Ligation of the left anterior descen......

JIF:2.795

NPAS4 Polymorphisms Contribute to Coronary Heart Disease (CHD) Risk

期刊: CARDIOVASCULAR TOXICOLOGY, 2022; 22 (6)

As genetic inheritance is an inevitable risk factor in the development of coronary heart disease (CHD), it is critical to identify the polymorphisms o......

JIF:2.795

MiR-7a-5p Attenuates Hypoxia/Reoxygenation-Induced Cardiomyocyte Apoptosis by Targeting VDAC1

期刊: CARDIOVASCULAR TOXICOLOGY, 2022; 22 (2)

MicroRNA-7a-5p (miR-7a-5p) is closely related to apoptosis and plays an important role in ischemia/reperfusion (I/R) injury. Whether miR-7a-5p is invo......

JIF:2.795

Rosuvastatin Alleviates Coronary Microembolization-Induced Cardiac Injury by Suppressing Nox2-Induced ROS Overproduction and Myocardial Apoptosis

期刊: CARDIOVASCULAR TOXICOLOGY, 2022; 22 (4)

To explore the mechanism by which rosuvastatin prevents coronary microembolism (CME)-induced cardiac injury and cardiomyocyte apoptosis. Animal and ce......

JIF:2.795

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