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Integrated pathway engineering and transcriptome analysis for improved astaxanthin biosynthesis in Yarrowia lipolytica

期刊: SYNTHETIC AND SYSTEMS BIOTECHNOLOGY, 2022; 7 (4)

Astaxanthin is a high value carotenoid with a broad range of commercial applications due to its superior antioxidant properties. In this study, 8-caro......

Efficient fatty acid synthesis from methanol in methylotrophic yeast

期刊: SYNTHETIC AND SYSTEMS BIOTECHNOLOGY, 2022; 7 (4)

Methanol is an attractive C1 feedstock with high abundance and low cost in bio-manufacturing. However, the metabolic construction of cell factories to......

Characterizing and engineering promoters for metabolic engineering of Ogataea polymorpha

期刊: SYNTHETIC AND SYSTEMS BIOTECHNOLOGY, 2022; 7 (1)

Bio-manufacturing via microbial cell factory requires large promoter library for fine-tuned metabolic engineering. Ogataea polymorpha, one of the meth......

Enrichment of health-promoting lutein and zeaxanthin in tomato fruit through metabolic engineering

期刊: SYNTHETIC AND SYSTEMS BIOTECHNOLOGY, 2022; 7 (4)

Carotenoids constitute a large group of natural pigments widely distributed in nature. These compounds not only provide fruits and flowers with distin......

Enhancement and mapping of tolerance to salt stress and 5-fluorocytosine in synthetic yeast strains via SCRaMbLE

期刊: SYNTHETIC AND SYSTEMS BIOTECHNOLOGY, 2022; 7 (3)

Varied environmental stress can affect cell growth and activity of the cellular catalyst. Traditional path of adaptive evolution generally takes a lon......

Engineering Yarrowia lipolytica to produce nutritional fatty acids: Current status and future perspectives

期刊: SYNTHETIC AND SYSTEMS BIOTECHNOLOGY, 2022; 7 (4)

Due to their vital physiological functions, nutritional fatty acids have great potential as nutraceutical food supplements for preventing an array of ......

Development of a novel platform for recombinant protein production in Corynebacterium glutamicum on ethanol

期刊: SYNTHETIC AND SYSTEMS BIOTECHNOLOGY, 2022; 7 (2)

Corynebacterium glutamicum represents an emerging recombinant protein expression factory due to its ideal features for protein secretion, but its appl......

Putative functions of EpsK in teichuronic acid synthesis and phosphate starvation in Bacillus licheniformis

期刊: SYNTHETIC AND SYSTEMS BIOTECHNOLOGY, 2022; 7 (2)

Extracellular polymeric substances (EPSs) are extracellular macromolecules in bacteria, which function in cell growth and show potential for mechanism......

Engineering Shewanella carassii, a newly isolated exoelectrogen from activated sludge, to enhance methyl orange degradation and bioelectricity harvest

期刊: SYNTHETIC AND SYSTEMS BIOTECHNOLOGY, 2022; 7 (3)

Electroactive microorganisms (EAMs) play important roles in biogeochemical redox processes and have been of great interest in the fields of energy rec......

Sequence and thermodynamic characteristics of terminators revealed by FlowSeq and the discrimination of terminators strength

期刊: SYNTHETIC AND SYSTEMS BIOTECHNOLOGY, 2022; 7 (4)

The intrinsic terminator in prokaryotic forms secondary RNA structure and terminates the transcription. However, leaking transcription is common due t......

Norditerpenoids biosynthesized by variediene synthase-associated P450 machinery along with modifications by the host cell Aspergillus oryzae

期刊: SYNTHETIC AND SYSTEMS BIOTECHNOLOGY, 2022; 7 (4)

The chemical diversity of terpenoids is typically established by terpene synthase-catalyzed cyclization and diversified by post-tailoring modification......

Translocation of subunit PPSE in plipastatin synthase and synthesis of novel lipopeptides

期刊: SYNTHETIC AND SYSTEMS BIOTECHNOLOGY, 2022; 7 (4)

Nonribosomal peptide synthase (NRPS) is a unique molecular assembly mechanism with high hybridity. Its recombination is conducive to the development o......

Optimization of microbial cell factories for astaxanthin production: Biosynthesis and regulations, engineering strategies and fermentation optimization strategies

期刊: SYNTHETIC AND SYSTEMS BIOTECHNOLOGY, 2022; 7 (2)

The global market demand for natural astaxanthin is rapidly increasing owing to its safety, the potential health benefits, and the diverse application......

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