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Toad venom: A comprehensive review of chemical constituents, anticancer activities, and mechanisms

期刊: ARCHIV DER PHARMAZIE, 2021; 354 (7)

Toad venom, a traditional natural medicine, has been used for hundreds of years in China for treating different diseases. Many studies have been perfo......

Purification of a novel protein with cytotoxicity against non-small-cell lung cancer cells from Boletus bicolor

期刊: ARCHIV DER PHARMAZIE, 2021; 354 (9)

A novel protein (D1 component) was purified from Boletus bicolor by ion-exchange chromatography and gel chromatography on a HiTrap (TM) Q HP column, a......

Synthesis and anticancer activity of ethyl 5-amino-1-N-substituted-imidazole-4-carboxylate building blocks

期刊: ARCHIV DER PHARMAZIE, 2021; 354 (9)

A series of 5-amino-1-N-substituted-imidazole-4-carboxylate building blocks was synthesized and assayed for their antiproliferative potential against ......

Design, synthesis, and biological evaluation of 5-aminotetrahydroquinoline-based LSD1 inhibitors acting on Asp375

期刊: ARCHIV DER PHARMAZIE, 2021; 354 (8)

The abnormal expression of lysine-specific histone demethylase 1 (LSD1) is associated with different cancer types, and LSD1 inhibitory activity seems ......

Anticancer activities, structure-activity relationship, and mechanism of action of 12-, 14-, and 16-membered macrolactones

期刊: ARCHIV DER PHARMAZIE, 2021; 354 (9)

Cancer remains one of the major causes of death worldwide despite the encouraging breakthroughs in the discovery of novel chemotherapeutic agents in r......

In vitro and in vivo evaluation of a water-in-oil microemulsion of platycodin D

期刊: ARCHIV DER PHARMAZIE, 2021; 354 (8)

Platycodin D (PD) is the active metabolite of Platycodon grandiflorum. The main purpose of this study was to develop and evaluate a water-in-oil (W/O)......

Synthesis and antitumor potential of new arylidene ursolic acid derivatives via caspase-8 activation

期刊: ARCHIV DER PHARMAZIE, ; ()

Continuing our studies on NO-donating ursolic acid-benzylidene derivatives as potential antitumor agents, we designed and synthesized a series of new ......

Design, synthesis, and biological evaluation of 1,2,4-oxadiazole-containing pyrazolo[3,4-b]pyridinones as a new series of AMPK alpha 1 beta 1 gamma 1 activators

期刊: ARCHIV DER PHARMAZIE, ; ()

Adenosine monophosphate-activated protein kinase (AMPK) plays a key role in maintaining whole-body homeostasis and has been regarded as a therapeutic ......

Natural indole-containing alkaloids and their antibacterial activities

期刊: ARCHIV DER PHARMAZIE, 2020; 353 (10)

As the growth in resistance to bacterial infection treatments poses a grave threat to global health in the 21st century, there is a constant need to e......

PXR-ABC drug transporters/CYP-mediated ursolic acid transport and metabolism in vitro and vivo

期刊: ARCHIV DER PHARMAZIE, 2020; 353 (9)

The transporting kinetics and metabolic kinetics of ursolic acid were studied in transgenic cell models. Then, the pharmacokinetics features of ursoli......

Discovery of 2,4-diaminopyrimidine derivatives targeting p21-activated kinase 4: Biological evaluation and docking studies

期刊: ARCHIV DER PHARMAZIE, 2020; 353 (10)

In this study, novel 2,4-diaminopyrimidine derivatives targeting p21-activated kinase 4 (PAK4) were discovered and evaluated for their biological acti......

Indole/isatin-containing hybrids as potential antibacterial agents

期刊: ARCHIV DER PHARMAZIE, 2020; 353 (10)

The emergence and worldwide spread of drug-resistant bacteria have already posed a serious threat to human life, creating the urgent need to develop p......

Synthesis and biological evaluation of substituted pyrrolidines and pyrroles as potential anticancer agents

期刊: ARCHIV DER PHARMAZIE, 2020; 353 (12)

A series of polysubstituted pyrrolidines obtained via ruthenium-catalyzed cascade cyclization of diazo pyruvates and anilines as well as their corresp......

The antimalarial activity of indole alkaloids and hybrids

期刊: ARCHIV DER PHARMAZIE, 2020; 353 (11)

Malaria, caused by the genusPlasmodium, remains a global public health concern. It is estimated by the World Health Organization that over 40% of the ......

Recent advances in isatin hybrids as potential anticancer agents

期刊: ARCHIV DER PHARMAZIE, 2020; 353 (3)

The isatin framework is a useful template for the development of novel anticancer agents. This is exemplified by the fact that several isatin-based an......

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