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Therapeutic development of group B Streptococcus meningitis by targeting a host cell signaling network involving EGFR

期刊: EMBO MOLECULAR MEDICINE, 2021; 13 (3)

Group B Streptococcus (GBS) remains the most common Gram-positive bacterium causing neonatal meningitis and GBS meningitis continues to be an importan......

SLC6A20 transporter: a novel regulator of brain glycine homeostasis and NMDAR function

期刊: EMBO MOLECULAR MEDICINE, 2021; 13 (2)

Glycine transporters (GlyT1 and GlyT2) that regulate levels of brain glycine, an inhibitory neurotransmitter with co-agonist activity for NMDA recepto......

A positive feedback loop between mTORC1 and cathelicidin promotes skin inflammation in rosacea

期刊: EMBO MOLECULAR MEDICINE, 2021; 13 (5)

Rosacea is a chronic inflammatory skin disorder whose pathogenesis is unclear. Here, several lines of evidence were provided to demonstrate that mTORC......

Epithelial response to IFN-gamma promotes SARS-CoV-2 infection

期刊: EMBO MOLECULAR MEDICINE, 2021; 13 (4)

SARS-CoV-2, the agent that causes COVID-19, invades epithelial cells, including those of the respiratory and gastrointestinal mucosa, using angiotensi......

Synergistic effects of FGFR1 and PLK1 inhibitors target a metabolic liability in KRAS-mutant cancer

期刊: EMBO MOLECULAR MEDICINE, 2021; 13 (9)

KRAS oncoprotein is commonly mutated in human cancer, but effective therapies specifically targeting KRAS-driven tumors remain elusive. Here, we show ......

Tenascin-C immobilizes infiltrating T lymphocytes through CXCL12 promoting breast cancer progression

期刊: EMBO MOLECULAR MEDICINE, 2021; 13 (6)

Immune checkpoint therapy, where CD8 tumor infiltrating T lymphocytes (TIL) are reactivated, is a promising anti-cancer treatment approach, yet with l......

Aducanumab: a new phase in therapeutic development for Alzheimer's disease?

期刊: EMBO MOLECULAR MEDICINE, 2021; 13 (8)

On 7 June(,) the FDA approved aducanumab, the first new drug for Alzheimer's disease in almost 20 years-and notably, the first drug with a putative di......

Nanog maintains stemness of Lkb1-deficient lung adenocarcinoma and prevents gastric differentiation

期刊: EMBO MOLECULAR MEDICINE, 2021; 13 (3)

Growing evidence supports that LKB1-deficient KRAS-driven lung tumors represent a unique therapeutic challenge, displaying strong cancer plasticity th......

The global emergence of a novel Streptococcus suis clade associated with human infections

期刊: EMBO MOLECULAR MEDICINE, 2021; 13 (7)

Streptococcus suis, a ubiquitous bacterial colonizer in pigs, has recently extended host range to humans, leading to a global surge of deadly human in......

NF45/NF90-mediated rDNA transcription provides a novel target for immunosuppressant development

期刊: EMBO MOLECULAR MEDICINE, 2021; 13 (3)

Herein, we demonstrate that NFAT, a key regulator of the immune response, translocates from cytoplasm to nucleolus and interacts with NF45/NF90 comple......

Menin-regulated Pbk controls high fat diet-induced compensatory beta cell proliferation

期刊: EMBO MOLECULAR MEDICINE, 2021; 13 (5)

Pancreatic beta cells undergo compensatory proliferation in the early phase of type 2 diabetes. While pathways such as FoxM1 are involved in regulatin......

Identification of TAPBPL as a novel negative regulator of T-cell function

期刊: EMBO MOLECULAR MEDICINE, 2021; 13 (5)

T cell stimulatory and inhibitory molecules are critical for the regulation of immune responses. In this study, we identify a novel T cell co-inhibito......

Rational design of West Nile virus vaccine through large replacement of 3 ' UTR with internal poly(A)

期刊: EMBO MOLECULAR MEDICINE, 2021; 13 (9)

The genus Flavivirus comprises numerous emerging and re-emerging arboviruses causing human illness. Vaccines are the best approach to prevent flavivir......

The state of the art of bispecific antibodies for treating human malignancies

期刊: EMBO MOLECULAR MEDICINE, 2021; 13 (9)

Bispecific antibodies (bsAb) that target two independent epitopes or antigens have been extensively explored in translational and clinical studies sin......

Gut microbiota-CRAMP axis shapes intestinal barrier function and immune responses in dietary gluten-induced enteropathy

期刊: EMBO MOLECULAR MEDICINE, 2021; 13 (8)

In the gut, cathelicidin-related antimicrobial peptide (CRAMP) has been largely described for its anti-infective activities. With an increasing recogn......

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