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Metformin ameliorates bladder dysfunction in a rat model of partial bladder outlet obstruction

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2021; 320 (5)

Alteration of bladder morphology and function was the most important consequence of bladder outlet obstruction (BOO). Using a rat model of partial BOO......

The novel STING antagonist H151 ameliorates cisplatin-induced acute kidney injury and mitochondrial dysfunction

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2021; 320 (4)

Stimulator of interferon genes (STING) is an important adaptor in cytosolic DNA-sensing pathways. A recent study found that the deletion of STING amel......

HIF-1 alpha is transcriptionally regulated by NF-kappa B in acute kidney injury

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2021; 321 (2)

Oxygen homeostasis disturbances play a critical role in the pathogenesis of acute kidney injury (AKI). The transcription factor hypoxia-inducible fact......

Disparate roles of retinoid acid signaling molecules in kidney disease

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2021; 320 (5)

Retinoid acid (RA) is synthesized mainly in the fiver and has multiple functions in development, cell differentiation and proliferation, and regulatio......

Deletion of renal Nedd4-2 abolishes the effect of high K+ intake on Kir4.1/Kir5.1 and NCC activity in the distal convoluted tubule

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2021; 321 (1)

High-dietary K+ (HK) intake inhibits basolateral Kir4.1/Kir5.1 activity in the distal convoluted tubule (DCT), and HK-induced inhibition of Kir4.1/Kir......

Regulated cell death in cisplatin-induced AKI: relevance of myo-inositol metabolism

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2021; 320 (4)

Regulated cell death (RCD), distinct from accidental cell death, refers to a process of well-controlled programmed cell death with well-defined pathol......

Deletion of Kir5.1 abolishes the effect of high Na+ intake on Kir4.1 and Na+-Cl- cotransporter

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2021; 320 (6)

High sodium (HS) intake inhibited epithelial Na+ channel (ENaC) in the aldosterone-sensitive distal nephron and Na+ -Cl- cotransporter (NCC) by suppre......

Deletion of renal Nedd4-2 abolishes the effect of high sodium intake (HS) on Kir4.1, ENaC, and NCC and causes hypokalemia during high HS

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2021; 320 (5)

Neural precursor cell expressed developmentally downregulated protein 4-2 (Nedd4-2) regulates the expression of Kir4.1, thiazide-sensitive NaCl cotran......

Porcine models of acute kidney injury

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2021; 320 (6)

Pigs represent a potentially attractive model for medical research. Similar body size and physiological patterns of kidney injury that more closely mi......

Local and downstream actions of proximal tubule angiotensin II signaling on Na+ transporters in the mouse nephron

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2021; 321 (1)

The renal nephron consists of a series of distinct cell types that function in concert to maintain fluid and electrolyte balance and blood pressure. T......

Role of soluble guanylyl cyclase in renal afferent and efferent arterioles

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2021; 320 (2)

Renal arteriolar tone depends considerably on the dilatory action of nitric oxide (NO) via activation of soluble guanylyl cyclase (sGC) and cGMP actio......

Activation of the RAS contributes to peritoneal fibrosis via dysregulation of low-density lipoprotein receptor

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2021; 320 (3)

Peritoneal dialysis (PD)-related peritoneal fibrosis (PF) is characterized by progressive extracellular matrix (ECM) accumulation in peritoneal mesoth......

Activation of TGR5 restores AQP2 expression via the HIF pathway in renal ischemia-reperfusion injury

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2021; 320 (3)

Renal ischemia-reperfusion (I/R) injury is associated with markedly reduced protein expression of aquaporins (AQPs). Membrane G protein-coupled bile a......

Generation and characterization of a novel rat model of primary hyperoxaluria type 1 with a nonsense mutation in alanine-glyoxylate aminotransferase gene

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2021; 320 (3)

Primary hyperoxaluria type 1 (PH1) is a severe inherited disorder caused by a genetic defect in alanine-glyoxylate aminotransferase (AGXT), which resu......

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