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Palmitoylethanolamide: Prenatal Developmental Toxicity Study in Rats

期刊: INTERNATIONAL JOURNAL OF TOXICOLOGY, 2021; 40 (2)

Palmitoylethanolamide (PEA) is an endogenous ethanolamine playing a protective and homeodynamic role in animals and plants. Prenatal developmental tox......

Aflatoxin B1-Induced COX-2 Expression Promotes Mitophagy and Contributes to Lipid Accumulation in Hepatocytes In Vitro and In Vivo

期刊: INTERNATIONAL JOURNAL OF TOXICOLOGY, 2020; 39 (6)

Aim: Aflatoxin B1 (AFB1) is hepatotoxic. Numerous studies have shown that mitochondria play an essential role in AFB1-induced steatosis. However, the ......

Toxicity Assessment of 4 Azo Dyes in Zebrafish Embryos

期刊: INTERNATIONAL JOURNAL OF TOXICOLOGY, 2020; 39 (2)

Azo dyes are used widely as color additives in food, drugs, and cosmetics; hence, there is an increasing concern about their safety and possible healt......

Nonclinical Safety Assessment of Zanubrutinib: A Novel Irreversible BTK Inhibitor

期刊: INTERNATIONAL JOURNAL OF TOXICOLOGY, 2020; 39 (3)

Zanubrutinib an oral irreversible Bruton's tyrosine kinase (BTK) inhibitor, is under development for the treatment of a variety of B-cell malignancies......

Safety Study of Single-Dose Intravenously Administered DOTA-Siglec-9 Peptide in Sprague Dawley Rats

期刊: INTERNATIONAL JOURNAL OF TOXICOLOGY, 2019; 38 (1)

The peptide-based radioactive compound [Ga-68]Ga-DOTA-Siglec-9 is a novel agent for imaging of inflammation with positron emission tomography. The dru......

JIF:1.22

Lipoxygenase Protein Expression and Its Effect on Oxidative Stress Caused by Benzidine in Normal Human Urothelial Cell Lines

期刊: INTERNATIONAL JOURNAL OF TOXICOLOGY, 2019; 38 (2)

Metabolic activation of indirect-acting carcinogens in the target organ is an effective mechanism of carcinogenesis. Lipoxygenase (LOX) can co-oxidize......

JIF:1.22

Autophagy in Triptolide-Mediated Cytotoxicity in Hepatic Cells

期刊: INTERNATIONAL JOURNAL OF TOXICOLOGY, 2019; 38 (5)

Triptolide is a major active ingredient isolated from the traditional Chinese herb Tripterygium wilfordii Hook F. However, its use in clinical practic......

JIF:1.22

Trimethyltin (TMT) Reduces Testosterone Production in Adult Leydig Cells in Rats

期刊: INTERNATIONAL JOURNAL OF TOXICOLOGY, 2019; 38 (6)

Trimethyltin (TMT) is widely used as a plastic heat stabilizer and can cause severe toxicity. Here, the effects of TMT on testosterone production by a......

JIF:1.22

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