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Immune-related biomarkers in triple-negative breast cancer

期刊: BREAST CANCER, 2021; 28 (4)

Breast cancer is a commonly diagnosed female cancer in the world. Triple-negative breast cancer (TNBC) is the most dangerous and biologically aggressi......

Clinicopathologic and genetic features of metaplastic breast cancer with osseous differentiation: a series of 6 cases

期刊: BREAST CANCER, 2021; 28 (5)

Aims Metaplastic breast cancer (MBC) comprises a heterogeneous group of tumors, of which MBC with osseous differentiation (MBC-OD) is extremely rare t......

Overexpression of SERPINA3 promotes tumor invasion and migration, epithelial-mesenchymal-transition in triple-negative breast cancer cells

期刊: BREAST CANCER, ; ()

Background Recent studies have indicated that serpin peptidase inhibitor, clade A, member 3 (SERPINA3) is a potential marker associated with tumor pro......

Adenosquamous carcinoma of the breast: a population-based study

期刊: BREAST CANCER, ; ()

Background To summarize the clinicopathological characteristics, prognosis, and management of breast adenosquamous carcinoma (ASC). Methods A populati......

Optimal duration of endocrine therapy with extended aromatase inhibitors for postmenopausal patients with hormone receptor-positive breast cancer: a meta-analysis

期刊: BREAST CANCER, ; ()

Background The optimal duration of endocrine therapy for patients with hormone receptor-positive (HR-positive) breast cancer is still unclear. This me......

Reliable assessment of BRCA1 and BRCA2 germline variants by next-generation sequencing: a multicenter study

期刊: BREAST CANCER, ; ()

Background BRCA1/2 gene mutation testing, based on next-generation sequencing (NGS), has been gradually applied in the clinic to serve as preventive e......

An immune-related risk gene signature predicts the prognosis of breast cancer

期刊: BREAST CANCER, ; ()

Background Accurate prediction of the outcome of breast cancer remains as a challenge due to its heterogeneous nature. We aimed to construct an immune......

Discovery and function exploration of microRNA-155 as a molecular biomarker for early detection of breast cancer

期刊: BREAST CANCER, ; ()

Background MicroRNA-155 (miR-155) may function as a diagnostic biomarker of breast cancer (BC). Nevertheless, the available evidence is controversial.......

Human umbilical cord mesenchymal stem cell-derived exosomes inhibit migration and invasion of breast cancer cells via miR-21-5p/ZNF367 pathway

期刊: BREAST CANCER, ; ()

Background Human umbilical cord mesenchymal stem cell-derived exosomes (hucMSC-exos) exhibit various roles in breast cancer development. The molecular......

PIK3CA somatic alterations in invasive breast cancers: different spectrum from Caucasians to Chinese detected by next generation sequencing

期刊: BREAST CANCER, ; ()

Purpose Somatic alteration of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) is a crucial therapeutic target in breas......

Tumor markers CA15-3, CA125, CEA and breast cancer survival by molecular subtype: a cohort study

期刊: BREAST CANCER, 2020; 27 (4)

Background The burden of breast cancer has grown rapidly in China during recent decades. However, the association between tumor markers (CA15-3, CA125......

A network meta-analysis on the efficacy of HER2-targeted agents in combination with taxane-containing regimens for treatment of HER2-positive metastatic breast cancer

期刊: BREAST CANCER, 2020; 27 (2)

Purpose We performed a network meta-analysis of randomized controlled trials (RCTs) to evaluate the efficacy of HER2-targeted agents in combination wi......

miR-485-5p inhibits the progression of breast cancer cells by negatively regulating MUC1

期刊: BREAST CANCER, 2020; 27 (4)

Objective To investigate the mechanism of miR-485-5p inhibiting breast cancer cells by targeting MUC1. Methods Differentially expressed genes (DEGs) i......

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