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Identification of the key genes and immune infiltrating cells determined by sex differences in ischaemic stroke through co-expression network module

期刊: IET SYSTEMS BIOLOGY, 2022; 16 (1)

Stroke is one of the leading causes of patients' death and long-term disability worldwide, and ischaemic stroke (IS) accounts for nearly 80% of all st......

JIF:1.756

RYR2 mutation in non-small cell lung cancer prolongs survival via down-regulation of DKK1 and up-regulation of GS1-115G20.1: A weighted gene Co-expression network analysis and risk prognostic models

期刊: IET SYSTEMS BIOLOGY, 2022; 16 (2)

RYR2 mutation is clinically frequent in non-small cell lung cancer (NSCLC) with its function being elusive. We downloaded lung squamous cell carcinoma......

JIF:1.756

Identification of TNFAIP6 as a hub gene associated with the progression of glioblastoma by weighted gene co-expression network analysis

期刊: IET SYSTEMS BIOLOGY, 2022; 16 (5)

This study aims to discover the genetic modules that distinguish glioblastoma multiforme (GBM) from low-grade glioma (LGG) and identify hub genes. A c......

JIF:1.756

PPDTS: Predicting potential drug-target interactions based on network similarity

期刊: IET SYSTEMS BIOLOGY, 2022; 16 (1)

Identification of drug-target interactions (DTIs) has great practical importance in the drug discovery process for known diseases. However, only a sma......

JIF:1.756

Dynamic changes of serum cytokines in acute paraquat poisoning and changes in patients' immune function

期刊: IET SYSTEMS BIOLOGY, 2022; 16 (3-4)

Acute paraquat poisoning is due to the extremely severe toxicity of paraquat. After paraquat enters the human body, it will cause rapid changes in the......

JIF:1.756

A novel m6A-related prognostic signature for predicting the overall survival of hepatocellular carcinoma patients

期刊: IET SYSTEMS BIOLOGY, 2022; 16 (1)

Liver hepatocellular carcinoma (LIHC) comprises most cases of liver cancer with a poor prognosis. N-6-methyladenosine (m6A) plays important biological......

JIF:1.756

Identification and validation of a seven-gene prognostic marker in colon cancer based on single-cell transcriptome analysis

期刊: IET SYSTEMS BIOLOGY, 2022; 16 (2)

Colon cancer (CC) is one of the most commonly diagnosed tumours worldwide. Single-cell RNA sequencing (scRNA-seq) can accurately reflect the heterogen......

JIF:1.756

SRAS-net: Low-resolution chromosome image classification based on deep learning

期刊: IET SYSTEMS BIOLOGY, 2022; 16 (3-4)

Prenatal karyotype diagnosis is important to determine if the foetus has genetic diseases and some congenital diseases. Chromosome classification is a......

JIF:1.756

Identifying driver modules based on multi-omics biological networks in prostate cancer

期刊: IET SYSTEMS BIOLOGY, 2022; 16 (6)

The development of sequencing technology has promoted the expansion of cancer genome data. It is necessary to identify the pathogenesis of cancer at t......

JIF:1.756

Disrupted myelination network in the cingulate cortex of Parkinson's disease

期刊: IET SYSTEMS BIOLOGY, 2022; 16 (3-4)

The cingulate cortex is part of the conserved limbic system, which is considered as a hub of emotional and cognitive control. Accumulating evidence su......

JIF:1.756

Construction and validation of m(6)A RNA methylation regulators associated prognostic model for gastrointestinal cancer

期刊: IET SYSTEMS BIOLOGY, 2022; 16 (2)

N6-methyladenosine (m(6)A) RNA methylation is correlated with carcinogenesis and dynamically possessed through the m(6)A RNA methylation regulators. T......

JIF:1.756

Weighted gene co expression network analysis (WGCNA) with key pathways and hub-genes related to micro RNAs in ischemic stroke

期刊: IET SYSTEMS BIOLOGY, 2021; 15 (3)

Ischemic stroke (IS) is one of the major causes of death and disability worldwide. However, the specific mechanism of gene interplay and the biologica......

Effects of noise and time delay on E2F's expression level in a bistable Rb-E2F gene's regulatory network

期刊: IET SYSTEMS BIOLOGY, 2021; 15 (4)

The bistable Rb-E2F gene regulatory network plays a central role in regulating cellular proliferation-quiescence transition. Based on Gillespie's chem......

Pathway-based protein-protein association network to explore mechanism of alpha-glucosidase inhibitors from Scutellaria baicalensis Georgi against type 2 diabetes

期刊: IET SYSTEMS BIOLOGY, 2021; 15 (4)

Natural products have been widely used in the treatment of type 2 diabetes (T2D). However, their mechanisms are often obscured due to multi-components......

A two-stage neural network prediction of chronic kidney disease

期刊: IET SYSTEMS BIOLOGY, 2021; 15 (5)

Accurate detection of chronic kidney disease (CKD) plays a pivotal role in early diagnosis and treatment. Measured glomerular filtration rate (mGFR) i......

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