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Urinary 8-oxo-7,8-dihydroguanosine levels are elevated in HCV-infected patients

期刊: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2021; 40 (9)

HCV patients are usually under substantial oxidative stress because of viral infection. A total of 177 patients with HCV infection and 198 age- and se......

Fluorescent labeling of s(2)T-incorporated DNA and m(5)s(2)U-modified RNA

期刊: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2021; 40 (7)

We report herein comprehensive investigations of alkylation/sulfur exchange reactions of sulfur-containing substrates including nucleosides such as s(......

HMGA2 rs968697 T > C polymorphism is associated with the risk of colorectal cancer

期刊: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2021; 40 (8)

A genetic polymorphism (rs968697 T > C) in the HMGA2 gene has recently been linked to an increased risk of hepatoblastoma. However, no studies have......

Synthesis of 7-trifluoromethyl-7-deazapurine ribonucleoside analogs and their monophosphate prodrugs

期刊: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2020; 39 (5)

Novel 7-trifluoromethyl-7-deazapurine ribonucleoside analogs (13a-c) and their Protides (15a-c) were successfully synthesized from ribolactol or 1-alp......

MicroRNA-30b participates in the pathological process of hyperuricemia by regulating interleukin-6 receptor

期刊: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2020; 39 (8)

The present study aimed to examine the expression of hyperuricemia (HUA)-related factors in the body fluids of HUA patients and in renal tissues and b......

CD123 thioaptamer protects against sepsis via the blockade between IL-3/CD123 in a cecal ligation and puncture rat model

期刊: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2020; 40 (1)

Sepsis is one of the most common causes of death in ICU and especially is a harmful and a life-threatened disease to pediatrics in the world. It has b......

The solid-state and solution conformations of 2 '-deoxy-2 '-fluoro-4 '-substituted nucleosides

期刊: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2020; 40 (2)

The conformational features of drugs are important with respect to their biological activity. In this report, we confirmed the solid-state conformatio......

Synthesis and evaluation of antitumor activities of 4-selenopyrimidine derivatives

期刊: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2020; 40 (1)

Pyrimidine antimetabolic agents are the essential drugs in treatment of various tumors. Novel synthesis and biological evaluation of the pyrimidine de......

Removal of 1,2-benzanthracene via the intercalation of 1,2-benzanthracene with DNA and magnetic bead-based separation

期刊: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2020; 40 (2)

In this study, DNA-functionalize-magnetic beads were investigated as sorbent materials for effective removing 1,2-benzanthracene (BaA) from water. In ......

Evaluation of the effect of Tb(IV)-NR complex on herring sperm DNA genetic information by mean of spectroscopic

期刊: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2020; 39 (7)

The interaction between Tb(IV)-NR complex and herring sperm DNA in buffer solution of Tris-HCl was investigated with the use of acridine orange(AO) as......

DNA groove-binding and acid-base properties of a Ru(II) complex containing anthryl moieties

期刊: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 0; ()

DNA groove binders have been poorly studied as compared to the intercalators. A novel Ru(II) complex of [Ru(aeip)(2)(Haip)](PF6)(2) {Haip = 2-(9-anthr......

Intracellular metabolism and potential cardiotoxicity of a ?-D-2?-C-methyl-2,6-diaminopurine ribonucleoside phosphoramidate that inhibits hepatitis C virus replication

期刊: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 0; ()

?-D-2?-C-Methyl-2,6-diaminopurine ribonucleoside (2?-C-Me-DAPN) phosphoramidate prodrug (DAPN-PD) is a selective hepatitis C virus inhibitor that is m......

Targeted discovery and identification of novel nucleoside biomarkers in Apostichopus japonicus viscera using metabonomics

期刊: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2019; 38 (3)

In this study, we investigated the metabonomic profiles of Apostichopus japonicus using an LC-MS-based method in conjunction with multivariate data an......

JIF:1.17

Disruption of nucleobase stacking to restore reactivity

期刊: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2019; 38 (8)

Strong intermolecular interaction can prevent an organic molecule from dissolving in a reaction solution, thereby jeopardizing its reactivity and usef......

JIF:1.17

The effects of pH and salts on nucleic acid partitioning during phenol extraction

期刊: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2019; 38 (4)

The partitioning of nucleic acids is sensitive to pH during phenol extraction. However, the exact effects of pH on phenol extraction had not been syst......

JIF:1.17

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