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A research on the mechanism of NSAID-related gastric ulcer treated by jia wei wu qi san based on the p38mapk signal pathway

期刊: PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2021; 34 (2)

This study aims to explore the mechanism of NSAID-related gastric ulcer treated by JIA WEI WU QI SAN. Clean-grade SD rats were randomly divided into f......

Effects of dexmedetomidine combined with citrate sufentanil on the prognosis of patients with severe pneumonia and respiratory failure requiring mechanical ventilation

期刊: PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2021; 34 (1)

To investigate the effects of dexmedetomidine combined with citrate sufentanil on the prognosis of patients with severe pneumonia and respiratory fail......

Antidepressant mechanism and active compounds of saffron from network pharmacology study

期刊: PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2021; 34 (2)

Saffron has been applied in depression treatment, but its antidepressant compounds and mechanisms are unclear. In this research, a network pharmacolog......

Value of erythrocyte sedimentation rate and serum epo levels in evaluating the condition and prognosis of COPD in the elderly

期刊: PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2021; 34 (1)

To investigate the value of erythrocyte sedimentation rate (ESR) and serum EPO levels in evaluating the condition and prognosis of chronic obstructive......

Simvastatin inhibites high glucose-induced renal tubular epithelial cells apoptosis by down-regulating miR-92a

期刊: PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2021; 34 (1)

This work aims to investigate the role of simvastatin (SIM) in renal tubular epithelial cells (HK-2) proliferation. The apoptosis model of HK-2 cells ......

Evaluation of efficiency omega 3 fatty acid improves the behavioural phenotype and protects against oxidative stress against MPP+ induces Parkinson's disease in mice

期刊: PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2021; 34 (3)

This experiment proposed to study the efficiency omega 3 fatty acid on behavioural phenotype of Parkinson's disease (PD) in mice. Totally 7 groups (ea......

Application of P53 mRNA in signal transduction mechanisms of skeletal muscle cells

期刊: PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2021; 34 (1)

By analyzing the effects of P53 inhibitors and ladder climbing exercise on P53 mRNA transcription in skeletal muscle of mice, the application of P53 m......

Lamotrigine loaded nano-liposomes enhance brain selectivity in vivo

期刊: PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2021; 34 (3)

For many patients with refractory epilepsy, antiepileptic drugs (AEDs) cannot reach effective therapeutic concentration in brain due to drugtolerance.......

15-hydroxystearate micelles for the delivery of aprepitant: Preparation, characterization, pharmacokinetics and tissue distribution in mice

期刊: PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2021; 34 (2)

This study developed a novel Aprepitant micells (APPT-Ms) formulation that uses a mixture of 15-hydroxystearate (HS15) as surfactant to solubilize AAP......

Combined effects of hydralazine and nitrate on serum biochemistry and left ventricular remodeling in chronic heart failure patients

期刊: PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2021; 34 (1)

To investigate the effects of hydralazine combined with nitrate on serum levels of Adropin and brain natriuretic peptide (BNP), left ventricular remod......

The antitumor effect of the combination of aconitine and crude monkshood polysaccharide on hepatocellular carcinoma

期刊: PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2021; 34 (3)

Aconitine, the main component in Radix Aconiti Lateralis Preparata, not only exerts the anti-tumor effect on Hepatocellular Carcinoma (HCC) but also d......

Protective effect of 5,6,7,8-trtrahydroxyflavone against acute hypobaric hypoxia induced-oxidative stress in mice

期刊: PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2021; 34 (2)

Severe oxidative stress triggered by acute hypobaric hypoxia (AHH) is harmful for lots of organs in body, especial brain and heart. Flavonoids with an......

Geniposide attenuates postischemic long-term potentiation via GluN2A

期刊: PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2021; 34 (3)

N-Methyl-D-aspartate receptor (NMDAR)-induced antioxidation is a significant cause of neuronal injury after ischemic stroke. In a previous work, we ve......

Effects of Yupingfeng nasal drops on serum cytokines, histopathology and eosinophil cationic protein in nasal mucosa of rats with allergic rhinitis

期刊: PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2021; 34 (4)

Allergic rhinitis (AR) is one of the most common atopic disorders, which seriously affects patients' quality of life. Yupingfeng (YPF) Power is a trad......

Genome wide association study and phylogenetic analysis of novel SARS-COV-2 virus among different countries

期刊: PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2021; 34 (4)

Corona Virus (COVID-19) outbreak has threatened the world, since it has become pandemic and spread all over the world. The causative agent SARS-COV2 h......

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