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Stilbene glycoside upregulates SIRT3/AMPK to promotes neuronal mitochondrial autophagy and inhibit apoptosis in ischemic stroke

期刊: ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE, 2021; 30 (2)

Background. Ischemic stroke, also known as cerebrovascular accident or cerebral stroke, occupies the first place in the world's top 10 causes of death......

Eplerenone inhibits oxidized low-density lipoprotein-induced proliferation and migration of vascular smooth muscle cells by downregulating GPER expression

期刊: ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE, 2021; 30 (4)

Background. Excessive proliferation and migration of vascular smooth muscle cells (VSMCs) are associated with the pathogenesis of atherosclerosis (AS)......

Arbutin inhibits inflammation and apoptosis by enhancing autophagy via SIRT1

期刊: ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE, 2021; 30 (5)

Background. SIRT1 plays a protective role against diabetic retinopathy as it regulates inflammation, apoptosis and autophagy of cells. Objectives. Thi......

MiR-let-7i inhibits CD4(+) T cell apoptosis in patients with acute coronary syndrome

期刊: ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE, 2021; 30 (8)

Background. Abnormal CD4(+) T cells appear in the peripheral blood of patients with acute coronary syndrome (ACS). Studies have confirmed that CD4(+) ......

Overexpression of HTRA1 increases the proliferation and migration of retinal pigment epithelium cells

期刊: ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE, 2021; 30 (8)

Background. Age-related macular degeneration (AMD) mainly affects the central region of retina and has many late-stage manifestations. Objectives. Age......

HO-1 participate in the protection of RES in rat heart suffered from hypothermic preservation

期刊: ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE, 2021; 30 (2)

Background. Resveratrol (RES) is a polyphenolic compound and natural phytoalexin that plays a potential role in various human diseases. Studies have c......

Notch pathway activation promotes the differentiation of beagle dog periodontal ligament stem cells to Schwann cells

期刊: ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE, 2021; 30 (7)

Background. Periodontal ligament stem cells (PDLSCs) have demonstrated the potential for differentiation into many cell types, though the molecular me......

The role of soluble programmed death protein-1 (sPD-1) and soluble programmed death ligand-1 (sPD-L1) in rat corneal transplantation rejection

期刊: ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE, 2021; 30 (1)

Background. Immunological rejection is one of the problems in corneal transplantation. Recently, some research found out that soluble programmed death......

The clinical value of high-density lipoprotein in the evaluation of new coronavirus pneumonia

期刊: ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE, 2021; 30 (2)

Background. The new coronavirus pneumonia (NCP, COVID-19) outbreak began in Wuhan in December 2019. The new coronavirus (2019 novel coronavirus (2019-......

Phenalen-1-one-mediated photodynamic therapy inhibits keloid graft progression by reducing vessel formation and promoting fibroblast apoptosis

期刊: ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE, 2021; 30 (4)

Background. Keloid is a unique refractory syndrome characterized by a proliferation disorder of the fibroblasts. Recently, photodynamic therapy (PDT) ......

Three cases of 3 beta-hydroxysteroid dehydrogenase deficiency: Clinical analysis

期刊: ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE, 2021; 30 (3)

Background: 3 beta-HSD deficiency is a rare type of congenital adrenal hyperplasia (CAH), which is caused by HSD3B2 gene mutations. Objectives: In ord......

miR-874 ameliorates retinopathy in diabetic rats by NF-kappa B signaling pathway

期刊: ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE, 2021; 30 (4)

Background. Increased activity of the NF-kappa B signaling pathway boosts the progression of retinopathy in diabetic rats. Objectives. Using a bioinfo......

Ginsenoside Rg1 induces senescence of leukemic stem cells by upregulating p16(INK4a) and downregulating hTERT expression

期刊: ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE, 2021; 30 (6)

Background. Leukemic stem cells (LSCs) play an important role in the pathogenesis of leukemia. This research attempted to clarify effects of the telom......

Clinical significance of evaluation of collateral circulation in short-term prognosis of wake-up stroke patients

期刊: ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE, 2021; 30 (2)

Background. In recent years, the clinical significance of collateral circulation in vascular embolism has been gradually found. Objectives. To investi......

Exenatide regulates inflammation and the production of reactive oxygen species via inhibition of S1PR2 synthesis

期刊: ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE, 2021; 30 (5)

Background. Microvascular dysfunction is one of the most serious complications of diabetic retinopathy (DR). As a novel treatment drug for type 2 diab......

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