期刊: COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2021; 11 (8)
In early 2013, human infections caused by a novel H7N9 avian influenza virus (AIV) were first reported in China; these infections caused severe diseas......
期刊: COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2021; 11 (4)
Influenza is a global challenge, and future pandemics of influenza are inevitable. One of the lessons learned from past pandemics is that all pandemic......
期刊: COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2021; 11 (9)
Cancer interception refers to actively blocking the cancer development process by preventing progression of premalignancy to invasive disease. The rat......
期刊: COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2020; 10 (1)
Hidden hearing loss (HHL), a recently described auditory disorder, has been proposed to affect auditory neural processing and hearing acuity in subjec......
期刊: COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2020; 10 (2)
The tumor suppressor phosphatase and tension homolog (PTEN) is frequently mutated in human cancers, and it functions in multiple ways to safeguard cel......
期刊: COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2020; 10 (8)
Metastasis, which occurs when cancer cells disseminate from the primary tumor site to other parts of the body, is the primary cause of mortality in pa......
期刊: COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2020; 10 (10)
PTEN is one of the most frequently mutated tumor suppressor genes in human cancers. By counteracting the PI3K/AKT/mTOR pathway, PTEN plays an essentia......
期刊: COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2020; 10 (10)
Bone is a frequent site of metastases in many cancers. Both bone properties and the tumor-intrinsic traits are associated with the metastatic propensi......
期刊: COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2022; 12 (2)
The continuous emergence and reemergence of diverse subtypes of influenza A viruses, which are known as HxNy and are mediated through the reassortment......
期刊: COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2019; 9 (1)
Hepatitis E virus (HEV) possesses many of the features of other positive-stranded RNA viruses but also adds HEV-specific nuances, making its virus-hos......
期刊: COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2019; 9 (3)
Similar to other hepatotropic viruses, hepatitis E virus (HEV) has been notoriously difficult to propagate in cell culture, limiting studies to unrave......
期刊: COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2019; 9 (7)
Connexin 26 and connexin 30 are the prevailing isoforms in the epithelial and connective tissue gap junction systems of the developing and mature coch......
期刊: COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2019; 9 (9)
Gene- and cell-based therapies are well recognized as central pillars of next-generation medicine, but controllability remains a critical issue for cl......