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H7N9 Influenza Virus in China

期刊: COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2021; 11 (8)

In early 2013, human infections caused by a novel H7N9 avian influenza virus (AIV) were first reported in China; these infections caused severe diseas......

The Epidemiology, Virology, and Pathogenicity of Human Infections with Avian Influenza Viruses

期刊: COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2021; 11 (4)

Influenza is a global challenge, and future pandemics of influenza are inevitable. One of the lessons learned from past pandemics is that all pandemic......

Early Diagnosis and Screening for Lung Cancer

期刊: COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2021; 11 (9)

Cancer interception refers to actively blocking the cancer development process by preventing progression of premalignancy to invasive disease. The rat......

Hidden Hearing Loss: A Disorder with Multiple Etiologies and Mechanisms

期刊: COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2020; 10 (1)

Hidden hearing loss (HHL), a recently described auditory disorder, has been proposed to affect auditory neural processing and hearing acuity in subjec......

PTEN in Chromatin Remodeling

期刊: COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2020; 10 (2)

The tumor suppressor phosphatase and tension homolog (PTEN) is frequently mutated in human cancers, and it functions in multiple ways to safeguard cel......

New Approaches on Cancer Immunotherapy

期刊: COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2020; 10 (8)

Metastasis, which occurs when cancer cells disseminate from the primary tumor site to other parts of the body, is the primary cause of mortality in pa......

PTEN in Regulating Hematopoiesis and Leukemogenesis

期刊: COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2020; 10 (10)

PTEN is one of the most frequently mutated tumor suppressor genes in human cancers. By counteracting the PI3K/AKT/mTOR pathway, PTEN plays an essentia......

Bone Tropism in Cancer Metastases

期刊: COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2020; 10 (10)

Bone is a frequent site of metastases in many cancers. Both bone properties and the tumor-intrinsic traits are associated with the metastatic propensi......

Emerging HxNy Influenza A Viruses

期刊: COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2022; 12 (2)

The continuous emergence and reemergence of diverse subtypes of influenza A viruses, which are known as HxNy and are mediated through the reassortment......

JIF:6.782

Hepatitis E Virus Genome Structure and Replication Strategy

期刊: COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2019; 9 (1)

Hepatitis E virus (HEV) possesses many of the features of other positive-stranded RNA viruses but also adds HEV-specific nuances, making its virus-hos......

JIF:5.56

Stem Cell-Derived Culture Models of Hepatitis E Virus Infection

期刊: COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2019; 9 (3)

Similar to other hepatotropic viruses, hepatitis E virus (HEV) has been notoriously difficult to propagate in cell culture, limiting studies to unrave......

JIF:5.56

Inner Ear Connexin Channels: Roles in Development and Maintenance of Cochlear Function

期刊: COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2019; 9 (7)

Connexin 26 and connexin 30 are the prevailing isoforms in the epithelial and connective tissue gap junction systems of the developing and mature coch......

JIF:5.56

Optogenetic Medicine: Synthetic Therapeutic Solutions Precision-Guided by Light

期刊: COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2019; 9 (9)

Gene- and cell-based therapies are well recognized as central pillars of next-generation medicine, but controllability remains a critical issue for cl......

JIF:5.56

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