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Metabolic engineering of Corynebacterium glutamicum WM001 to improve l-isoleucine production

期刊: BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, 2021; 68 (3)

In this study, l-isoleucine production in Corynebacterium glutamicum WM001 was improved by deleting three genes in the genome, replacing the native pr......

Myocardial infarction biomarker C-reactive protein detection on nanocomposite aptasensor

期刊: BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, ; ()

Myocardial infarction (MI) is considered as one of the major life-threatening health issues worldwide. Growing number of cases every year is demanding......

Determination of cardiac disease biomarker by plasmonic sandwich ELISA

期刊: BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, ; ()

Acute myocardial infarction (AMI) is the heart attack happening when the blood flow is terminated to the heart muscles. C-reactive protein (CRP) level......

Application of natural products for inducing ferroptosis in tumor cells

期刊: BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, ; ()

Ferroptosis is a regulated cell death pathway based on the deposition of lipid-based reactive oxygen species (L-ROS) in the presence of iron ions. The......

Integrative identification of human serpin PAI-1 inhibitors from Dracaena dragon blood and molecular implications for inhibitor-induced PAI-1 allosterism

期刊: BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, ; ()

Human plasminogen activator inhibitor-1 (PAI-1) is an important component of the coagulation system and has been recognized as a potential therapeutic......

Glutamine alleviates the renal dysfunction associated with gentamicin-induced acute kidney injury in Sprague-Dawley rats

期刊: BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, ; ()

Sepsis is a clinical condition caused by an uncontrolled response to an infection, leading to acute kidney injury (AKI) and an increased risk of morta......

Upregulation of TRPM8 can promote the colon cancer liver metastasis through mediating Akt/GSK-3 signal pathway

期刊: BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, ; ()

This study aims to clarify the function of transient receptor potential melastatin 8 (TRPM8) in colon cancer liver metastasis. First, TRPM8 expression......

CircSEC24A promotes IL-1 beta-induced apoptosis and inflammation in chondrocytes by regulating miR-142-5p/SOX5 axis

期刊: BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, ; ()

Background Osteoarthritis (OA) is a common joint disease. Currently, many studies have revealed that circular RNAs (circRNAs) are strongly related to ......

The flavonoid 3 '-hydroxylase gene from the Antarctic moss Pohlia nutans is involved in regulating oxidative and salt stress tolerance

期刊: BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, ; ()

Flavonoids are the important secondary metabolites. They are thought to play an important role in plant adaptation to terrestrial environment. However......

Icaritin and icariin reduce p-Tau levels in a cell model of Alzheimer's disease by downregulating glycogen synthase kinase 3 beta

期刊: BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, ; ()

This study aimed to explore the neuroprotective effect of icariin/icaritin (ICA/ICT) and the role of ICA/ICT in the treatment of Alzheimer's disease (......

Downregulation of SDCBP inhibits cell proliferation and induces apoptosis by regulating PI3K/AKT/mTOR pathway in gastric carcinoma

期刊: BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, ; ()

Syndecan-binding protein (SDCBP) has been reported to critically process a core role in tumorigenesis. This study was conducted to characterize a nove......

Role of neddylation in neurological development and diseases

期刊: BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, ; ()

Neddylation, a posttranslational protein modification, refers to the specific conjugation of NEDD8 to substrates, which is of great significance to va......

Asiaticoside inhibits renal fibrosis development by regulating the miR-142-5p/ACTN4 axis

期刊: BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, ; ()

Renal fibrosis results in the progressive renal dysfunction and leads to chronic kidney disease (CKD) and ultimately end-stage renal disease. Asiatico......

Thyroglobulin determination on silane-antibody functionalized interdigitated dielectrode surface to diagnose thyroid tumor

期刊: BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, ; ()

Thyroid cancer appears in endocrine glands and specific to thyroid glands has been reported widely. This work was targeted to identify and quantify th......

High production of d-psicose from d-fructose by immobilized whole recombinant Bacillus subtilis cells expressing d-psicose 3-epimerase from Agrobacterium tumefaciens

期刊: BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, ; ()

d-Psicose 3-epimerase (DPEase) can catalyze the isomerization of d-fructose to be rare sugar d-psicose, which has wide application prospects in the fo......

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