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Inhibition of melanoma by survivin-specific lymphocytes combined with CCL17 and granulocyte-macrophage colony-stimulating factor in a mouse syngeneic model

期刊: ANTI-CANCER DRUGS, 2021; 32 (2)

As a new generation of treatment, tumor immunotherapy targeting tumor-associated antigens (TAA) has attracted widespread attention. The survivin antig......

Circ-ZNF124 downregulation inhibits non-small cell lung cancer progression partly by inactivating the Wnt/beta-catenin signaling pathway via mediating the miR-498/YES1 axis

期刊: ANTI-CANCER DRUGS, 2021; 32 (3)

Non-small cell lung cancer (NSCLC) is a major type of lung cancer, leading to a high fatality rate. The role of circular RNAs (circRNAs) in cancer has......

LFZ-4-46, a tetrahydroisoquinoline derivative, induces apoptosis and cell cycle arrest via induction of DNA damage and activation of MAPKs pathway in cancer cells

期刊: ANTI-CANCER DRUGS, 2021; 32 (8)

LFZ-4-46, that is [2-hydroxy-1-phenyl-1,5,6,10b-tetrahydropyrazolo(5,1-a) isoquinolin-3(2H)-yl](phenyl) methanone, a tetrahydroisoquinoline derivative......

Irreversible epidermal growth factor receptor inhibitor Z25h exhibits pronounced inhibition on non-small cell lung adenocarcinoma cell line Hcc827

期刊: ANTI-CANCER DRUGS, 2021; 32 (4)

The epidermal growth factor receptor (EGFR) signaling is frequently activated in lung cancer. In our previous study, a new class of compounds containi......

Sesquiterpene lactone Bigelovin induces apoptosis of colon cancer cells through inducing IKK-beta degradation and suppressing nuclear factor kappa B activation

期刊: ANTI-CANCER DRUGS, 2021; 32 (6)

Bigelovin, a sesquiterpene lactone extracted from plant Inula helianthus aquatica, exhibited multiple interesting biological activities, including ant......

miR-5701 promoted apoptosis of clear cell renal cell carcinoma cells by targeting phosphodiesterase-1B

期刊: ANTI-CANCER DRUGS, 2021; 32 (8)

Increasing evidence has demonstrated that microRNAs play critical roles in malignant biological behaviors, including cancerogenesis, cancer progressio......

Downregulation of caveolin-1 promotes murine breast cancer cell line progression by highly glycosylated CD147

期刊: ANTI-CANCER DRUGS, 2021; 32 (6)

Caveolin-1 (CAV-1) can extensively regulate lipid transportation, cell growth and cell death. In the present study, we revealed a novel function of CA......

The effect and mechanism of miR-607/CANT1 axis in lung squamous carcinoma

期刊: ANTI-CANCER DRUGS, 2021; 32 (7)

Lung squamous carcinoma (LUSC) is the second most frequent subtype of non-small cell lung cancer. Rarely gene alterations are identified in LUSC. Ther......

eIF4E-eIF4G complex inhibition synergistically enhances the effect of sorafenib in hepatocellular carcinoma

期刊: ANTI-CANCER DRUGS, 2021; 32 (8)

The clinical efficacy of sorafenib in hepatocellular carcinoma (HCC) is disappointing due to its low response rate and high rates of adverse effects. ......

Demonstrating the effect of SHP2 inhibitor on cervical squamous cell carcinoma from the perspective of ZAP70

期刊: ANTI-CANCER DRUGS, 2021; 32 (5)

SHP2, encoded by the PTPN11 gene, plays an important role in regulating immune cell functions in tumor microenvironment. Several SHP2 inhibitors have ......

Weekly versus triweekly cisplatin-alone adjuvant chemoradiotherapy after radical hysterectomy for stages IB-IIA cervical cancer with risk of recurrence

期刊: ANTI-CANCER DRUGS, 2021; 32 (2)

Weekly and triweekly cisplatin-alone concomitant chemoradiotherapy regimens after radical surgery were compared in stages IB-IIA cervical cancer with ......

MiR-337 suppresses pancreatic cancer development via STAT3/Wnt/beta-catenin axis

期刊: ANTI-CANCER DRUGS, 2021; 32 (7)

MiRNA is an important regulator of tumorigenesis and tumor progression. MiR-337 expression was increased in pancreatic cancer tissues and it was assoc......

SRY-related high-mobility-group box 6 suppresses cell proliferation and is downregulated in breast cancer

期刊: ANTI-CANCER DRUGS, 2021; 32 (3)

Breast cancer is one of the most common cancers endangering women's health. SRY-related high-mobility-group box 6 (SOX6) is associated with many cance......

Hopes and failures in front-line advanced HER2-positive gastric cancer therapy

期刊: ANTI-CANCER DRUGS, 2021; 32 (7)

Human epidermal growth-factor receptor 2 (HER2) was an important therapeutic target in gastric cancer. Through the last decade, strategy with trastuzu......

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